Zobrazeno 1 - 10
of 526
pro vyhledávání: '"Geoffrey W. McCaughan"'
Autor:
Marti Cabanes-Creus, Sophia H. Y. Liao, Renina Gale Navarro, Maddison Knight, Deborah Nazareth, Ngee-Soon Lau, Mark Ly, Erhua Zhu, Ramon Roca-Pinilla, Ricardo Bugallo Delgado, Ana F. Vicente, Grober Baltazar, Adrian Westhaus, Jessica Merjane, Michael Crawford, Geoffrey W. McCaughan, Carmen Unzu, Gloria González-Aseguinolaza, Ian E. Alexander, Carlo Pulitano, Leszek Lisowski
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Developing clinically predictive model systems for evaluating gene transfer and gene editing technologies has become increasingly important in the era of personalized medicine. Liver-directed gene therapies present a unique challenge due to
Externí odkaz:
https://doaj.org/article/adfc0f2727d740ed8d6f7bc8f0977ed6
Autor:
Kieran English, Rain Kwan, Lauren E. Holz, Claire McGuffog, Jelte M. M. Krol, Daryan Kempe, Tsuneyasu Kaisho, William R. Heath, Leszek Lisowski, Maté Biro, Geoffrey W. McCaughan, David G. Bowen, Patrick Bertolino
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract While CD4+ T cells are a prerequisite for CD8+ T cell-mediated protection against intracellular hepatotropic pathogens, the mechanisms facilitating the transfer of CD4-help to intrahepatic CD8+ T cells are unknown. Here, we developed an expe
Externí odkaz:
https://doaj.org/article/6f41999c730741ea852dc4aa086f5180
Publikováno v:
Cells, Vol 13, Iss 15, p 1289 (2024)
Hepatocellular carcinoma (HCC) is the fourth-leading cause of cancer-related death worldwide. Due to the high mortality rate in HCC patients, discovering and developing novel systemic treatment options for HCC is a vital unmet medical need. Among the
Externí odkaz:
https://doaj.org/article/91873a7b05864de9ab6c9248889c8aae
Autor:
Ken Liu, Jinbiao Chen, Yang Zhao, Jade Boland, Ka Ka Ting, Glen Lockwood, Catriona McKenzie, James Kench, Mathew A. Vadas, Jennifer R. Gamble, Geoffrey W. McCaughan
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionLiver cancers exhibit abnormal (leaky) vasculature, hypoxia and an immunosuppressive microenvironment. Normalization of tumor vasculature is an emerging approach to treat many cancers. Blockmir CD5-2 is a novel oligonucleotide-based inhib
Externí odkaz:
https://doaj.org/article/dc2ca80bddc44224b7b4496b62a00d02
Autor:
Ken Liu, Claude Dennis, David S. Prince, Felix Marsh-Wakefield, Cositha Santhakumar, Jennifer R. Gamble, Simone I. Strasser, Geoffrey W. McCaughan
Publikováno v:
JHEP Reports, Vol 5, Iss 8, Pp 100792- (2023)
Summary: Vessels that encapsulate tumour clusters (VETC) is a distinct histologic vascular pattern associated with a novel mechanism of metastasis. First described in human cancers in 2004, its prevalence and prognostic significance in hepatocellular
Externí odkaz:
https://doaj.org/article/8e56a782bbd74e1ca033f2e7ca1567c9
Autor:
Shichao Zhu, Xiyun Rao, Yude Qian, Jinbiao Chen, Renhua Song, Huili Yan, Xi Yang, Junhao Hu, Xiaohong Wang, Zhiming Han, Yi Zhu, Renjing Liu, Justin Jong-Leong Wong, Geoffrey W. McCaughan, Xiangjian Zheng
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 6, Pp 1757-1783 (2022)
Background & Aims: The liver has complex interconnecting blood vessel and biliary networks; however, how the vascular and biliary network form and regulate each other and liver function are not well-understood. We aimed to examine the role of Heg in
Externí odkaz:
https://doaj.org/article/9c9ef969c97c4420b30290118e1793e1
Autor:
Claude Dennis, David S. Prince, Leila Moayed-Alaei, Devika Remash, Emily Carr-Boyd, David G. Bowen, Simone I. Strasser, Michael Crawford, Carlo Pulitano, James Kench, Geoffrey W. McCaughan, Catriona McKenzie, Ken Liu
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundVessels that encapsulate tumor clusters (VETC) is a novel vascular pattern seen on hepatocellular carcinoma (HCC) histology which has been shown to independently predict tumor recurrence and survival after liver resection. Its prognostic va
Externí odkaz:
https://doaj.org/article/1841024c7e004666b74a9dccd0999ea0
Autor:
John D. Chetwood, MBBS(Dist), DTM&H, Mark V. Wells, BSc, Tatiana Tsoutsman, PhD, Carlo Pulitano, MD, PhD, FRACS, Michael D. Crawford, MBBS, FRACS, M.Med, Ken Liu, BSc(Med), FRACP, Simone I. Strasser, MBBS, MD, FRACP, FAASLD, Geoffrey W. McCaughan, MBBS, PhD, FRACP, FAHMS, Avik Majumdar, MPHTM, PhD, FRACP
Publikováno v:
Transplantation Direct, Vol 8, Iss 7, p e1346 (2022)
Background. Controversy exists regarding the best predictive model of liver transplant waiting list (WL) mortality. Models for end-stage liver disease–glomerular filtration rate assessment in liver disease (MELD-GRAIL) and MELD-GRAIL-Na were recent
Externí odkaz:
https://doaj.org/article/ece39f33fcda46ceaabbd32b35cd8e1c
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The liver has long been known to possess tolerogenic properties. Early experiments in liver transplantation demonstrated that in animal models, hepatic allografts could be accepted across MHC-mismatch without the use of immunosuppression, and that tr
Externí odkaz:
https://doaj.org/article/53f4f4815e164e0387087b0a59d97f24
Autor:
Fiona M. Keane, Tsun-Wen Yao, Stefanie Seelk, Margaret G. Gall, Sumaiya Chowdhury, Sarah E. Poplawski, Jack H. Lai, Youhua Li, Wengen Wu, Penny Farrell, Ana Julia Vieira de Ribeiro, Brenna Osborne, Denise M.T. Yu, Devanshi Seth, Khairunnessa Rahman, Paul Haber, A. Kemal Topaloglu, Chuanmin Wang, Sally Thomson, Annemarie Hennessy, John Prins, Stephen M. Twigg, Susan V. McLennan, Geoffrey W. McCaughan, William W. Bachovchin, Mark D. Gorrell
Publikováno v:
FEBS Open Bio, Vol 4, Iss C, Pp 43-54 (2014)
The protease fibroblast activation protein (FAP) is a specific marker of activated mesenchymal cells in tumour stroma and fibrotic liver. A specific, reliable FAP enzyme assay has been lacking. FAP's unique and restricted cleavage of the post proline
Externí odkaz:
https://doaj.org/article/699a5667312a445ea11703a45af02b69