GIMAP6 is required for T cell maintenance and efficient autophagy in mice.

Autor: John C Pascall, Louise M C Webb, Eeva-Liisa Eskelinen, Silvia Innocentin, Noudjoud Attaf-Bouabdallah, Geoffrey W Butcher

Publikováno v: PLoS ONE, Vol 13, Iss 5, p e0196504 (2018)

The GTPases of the immunity-associated proteins (GIMAP) GTPases are a family of proteins expressed strongly in the adaptive immune system. We have previously reported that in human cells one member of this family, GIMAP6, interacts with the ATG8 fami

Externí odkaz: https://doaj.org/article/63c19bd830c542698c5a04bd97e461bc

Generation and characterisation of mice deficient in the multi-GTPase domain containing protein, GIMAP8.

Autor: Louise M C Webb, John C Pascall, Lucy Hepburn, Christine Carter, Martin Turner, Geoffrey W Butcher

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e110294 (2014)

GTPases of the immunity-associated protein family (GIMAPs) are predominantly expressed in mature lymphocytes. Studies of rodents deficient in GIMAP1, GIMAP4, or GIMAP5 have demonstrated that these GTPases regulate lymphocyte survival. In contrast to

Externí odkaz: https://doaj.org/article/b3ceed3a662b47bfa6c5bf76d9f4daf5

Survival of mature T cells in the periphery is intrinsically dependent on GIMAP1 in mice

Autor: Inxhina Avdo, Louise M. C. Webb, John C. Pascall, Preeta Datta, Geoffrey W. Butcher

Publikováno v: European Journal of Immunology. 47:84-93

An effective immune system depends upon the survival of mature T cells in the periphery. Members of the GIMAP family of GTPases have been proposed to regulate this homeostasis, supported by the paucity of peripheral T cells in rodents deficient for e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3643ceb6aaabfa78ca93af10922ca8da
https://doi.org/10.1002/eji.201646599

The miR-155–PU.1 axis acts on Pax5 to enable efficient terminal B cell differentiation

Autor: Geoffrey W. Butcher, Martin R Turner, Rebecca Leyland, Rinako Nakagawa, Philipp Staudacher, Alison Galloway, Dong Lu, Tom Henley, Elena Vigorito, Sara Boiani, Cei Abreu-Goodger, Simon Andrews, Stephen L. Nutt, Sandra Lazzaro

Publikováno v: The Journal of Experimental Medicine
Lu, D, Nakagawa, R, Lazzaro, S, Staudacher, P, Abreu-Goodger, C, Henley, T, Boiani, S, Leyland, R, Galloway, A, Andrews, S, Butcher, G, Nutt, S L, Turner, M & Vigorito, E 2014, ' The miR-155-PU.1 axis acts on Pax5 to enable efficient terminal B cell differentiation ', Journal of Experimental Medicine, vol. 211, no. 11, pp. 2183–2198 . https://doi.org/10.1084/jem.20140338

Lu et al. disrupt the interaction between miR-155 and the transcription factor PU.1 by specifically removing miR-155–binding site from PU.1 mRNA in mice. They show that this interaction is required for plasma cell formation and extrafollicular resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e2cfa2208d004537532b7d9f47ca08
http://europepmc.org/articles/PMC4203942

The autoimmunity-related GIMAP5 GTPase is a lysosome-associated protein

Autor: Amanda Hutchings, Amy Saunders, John C. Pascall, Geoffrey W. Butcher, Simon Walker, Nicholas A. Bright, Vivian W.Y. Wong, Nicholas T. Ktistakis, Christine Carter

Publikováno v: Self/Nonself. 1:259-268

A mutation in the rat GIMAP5 gene predisposes for autoimmunity, most famously in the BB rat model of autoimmune type 1 diabetes mellitus. This mutation is associated with severe peripheral T lymphopenia, as is mutation of the same gene in mice, but t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f16cb6863eab91bd12a1c083876fab50
https://doi.org/10.4161/self.1.3.12819