Zobrazeno 1 - 10
of 532
pro vyhledávání: '"Geoffrey W McCaughan"'
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 11 (2019)
The introduction of immunotherapies has been a major development in the treatment of many advanced cancers, including hepatocellular carcinoma (HCC). We are entering a new era of systemic therapy for advanced HCC associated with an explosion of clini
Externí odkaz:
https://doaj.org/article/d3050b8940de4deeb927b3f074d5b09c
Autor:
Christine Yee, Nathan M Main, Alexandra Terry, Igor Stevanovski, Annette Maczurek, Alison J Morgan, Sarah Calabro, Alison J Potter, Tina L Iemma, David G Bowen, Golo Ahlenstiel, Fiona J Warner, Geoffrey W McCaughan, Susan V McLennan, Nicholas A Shackel
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0215557 (2019)
BackgroundChronic inflammation is the driver of liver injury and results in progressive fibrosis and eventual cirrhosis with consequences including both liver failure and liver cancer. We have previously described increased expression of the highly m
Externí odkaz:
https://doaj.org/article/d0940ab7fa584a72b7bc28e44329defd
Autor:
Cecy R Xi, Arianna Di Fazio, Naveed Ahmed Nadvi, Karishma Patel, Michelle Sui Wen Xiang, Hui Emma Zhang, Chandrika Deshpande, Jason K K Low, Xiaonan Trixie Wang, Yiqian Chen, Christopher L D McMillan, Ariel Isaacs, Brenna Osborne, Ana Júlia Vieira de Ribeiro, Geoffrey W McCaughan, Joel P Mackay, W Bret Church, Mark D Gorrell
Publikováno v:
Molecules, Vol 25, Iss 22, p 5392 (2020)
Proteases catalyse irreversible posttranslational modifications that often alter a biological function of the substrate. The protease dipeptidyl peptidase 4 (DPP4) is a pharmacological target in type 2 diabetes therapy primarily because it inactivate
Externí odkaz:
https://doaj.org/article/fa9dcf2606954561b940299e84274b4d
Autor:
Shirley Uitte de Willige, Fiona M Keane, David G Bowen, Joyce J M C Malfliet, H Emma Zhang, Bharvi Maneck, Geoffrey W McCaughan, Frank W G Leebeek, Dingeman C Rijken, Mark D Gorrell
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178987 (2017)
BACKGROUND AND AIM:Circulating fibroblast activation protein (cFAP) is a constitutively active enzyme expressed by activated fibroblasts that has both dipeptidyl peptidase and endopeptidase activities. We aimed to assess the correlation between cFAP
Externí odkaz:
https://doaj.org/article/f1745d1ee4c94a02bdd005d616eb8aec
Autor:
Magdalena A Budzinska, Thomas Tu, William M H d'Avigdor, Geoffrey W McCaughan, Fabio Luciani, Nicholas A Shackel
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162586 (2016)
In hepatocellular carcinoma (HCC), somatic genome-wide DNA mutations are numerous, universal and heterogeneous. Some of these somatic mutations are drivers of the malignant process but the vast majority are passenger mutations. These passenger mutati
Externí odkaz:
https://doaj.org/article/40cffdb6863b47efb94ccf60efa57b74
Autor:
Roslyn Vongsuvanh, David van der Poorten, Tristan Iseli, Simone I Strasser, Geoffrey W McCaughan, Jacob George
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155800 (2016)
UNLABELLED:Robust biomarkers for population-level hepatocellular carcinoma (HCC) surveillance are lacking. We compared serum midkine (MDK), dickkopf-1 (DKK1), osteopontin (OPN) and AFP for HCC diagnosis in 86 HCC patients matched to 86 cirrhotics, 86
Externí odkaz:
https://doaj.org/article/345ab9892c2546a080f4f9b7159ba2e8
Autor:
Marti Cabanes-Creus, Sophia H. Y. Liao, Renina Gale Navarro, Maddison Knight, Deborah Nazareth, Ngee-Soon Lau, Mark Ly, Erhua Zhu, Ramon Roca-Pinilla, Ricardo Bugallo Delgado, Ana F. Vicente, Grober Baltazar, Adrian Westhaus, Jessica Merjane, Michael Crawford, Geoffrey W. McCaughan, Carmen Unzu, Gloria González-Aseguinolaza, Ian E. Alexander, Carlo Pulitano, Leszek Lisowski
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Developing clinically predictive model systems for evaluating gene transfer and gene editing technologies has become increasingly important in the era of personalized medicine. Liver-directed gene therapies present a unique challenge due to
Externí odkaz:
https://doaj.org/article/adfc0f2727d740ed8d6f7bc8f0977ed6
Autor:
Kieran English, Rain Kwan, Lauren E. Holz, Claire McGuffog, Jelte M. M. Krol, Daryan Kempe, Tsuneyasu Kaisho, William R. Heath, Leszek Lisowski, Maté Biro, Geoffrey W. McCaughan, David G. Bowen, Patrick Bertolino
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract While CD4+ T cells are a prerequisite for CD8+ T cell-mediated protection against intracellular hepatotropic pathogens, the mechanisms facilitating the transfer of CD4-help to intrahepatic CD8+ T cells are unknown. Here, we developed an expe
Externí odkaz:
https://doaj.org/article/6f41999c730741ea852dc4aa086f5180
Autor:
Sarah R Calabro, Annette E Maczurek, Alison J Morgan, Thomas Tu, Victoria W Wen, Christine Yee, Auvro Mridha, Maggie Lee, William d'Avigdor, Stephen A Locarnini, Geoffrey W McCaughan, Fiona J Warner, Susan V McLennan, Nicholas A Shackel
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e90571 (2014)
The classical paradigm of liver injury asserts that hepatic stellate cells (HSC) produce, remodel and turnover the abnormal extracellular matrix (ECM) of fibrosis via matrix metalloproteinases (MMPs). In extrahepatic tissues MMP production is regulat
Externí odkaz:
https://doaj.org/article/5fb65a4f64194cb481221ea58bfb0859
Autor:
Aric Bendorf, Patrick J Kelly, Ian H Kerridge, Geoffrey W McCaughan, Brian Myerson, Cameron Stewart, Bruce A Pussell
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62010 (2013)
During the past decade an increasing number of countries have adopted policies that emphasize donation after cardiocirculatory death (DCD) in an attempt to address the widening gap between the demand for transplantable organs and the availability of
Externí odkaz:
https://doaj.org/article/4dbe8bd92da644b9841f9f888c4d03ef