Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Geoffrey Tombaugh"'
Autor:
Ayano Matsushima, Sergio Sebastian Pineda, Jill R. Crittenden, Hyeseung Lee, Kyriakitsa Galani, Julio Mantero, Geoffrey Tombaugh, Manolis Kellis, Myriam Heiman, Ann M. Graybiel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
In human and mouse models of Huntington’s disease, Matsushima, Pineda et al. show, using snRNAsequencing, the two axes defining identities of striatal projection neurons are multiplexed and differentially compromised, calling for distinct therapies
Externí odkaz:
https://doaj.org/article/42e10406eed04eb79c0e9e20bd72c0d9
Autor:
Roger Cachope, Simon Gelman, Geoffrey Tombaugh, Tamara Perez-Rosello, Vahri Beaumont, D. James Surmeier
Publikováno v:
Movement Disorders. 34:684-696
BACKGROUND Huntington's disease (HD) is caused by a CAG repeat expansion in the huntingtin gene. This mutation leads to progressive dysfunction that is largely attributable to dysfunction of the striatum. The earliest signs of striatal pathology in H
Publikováno v:
Journal of Alzheimer's Disease
Genetically modified mice have provided insights into the progression and pathology of Alzheimer's disease (AD). Here, we have examined two mouse models of AD: the rTg4510 mouse, which overexpresses mutant human Tau gene, and the APP/PS1 mouse, which
Autor:
Tamara, Perez-Rosello, Simon, Gelman, Geoffrey, Tombaugh, Roger, Cachope, Vahri, Beaumont, D James, Surmeier
Publikováno v:
Movement disorders : official journal of the Movement Disorder Society. 34(5)
Huntington's disease (HD) is caused by a CAG repeat expansion in the huntingtin gene. This mutation leads to progressive dysfunction that is largely attributable to dysfunction of the striatum. The earliest signs of striatal pathology in HD are found
Publikováno v:
Alzheimer's & Dementia. 13
Autor:
Donald Button, Hans Maag, Frédéric Knoflach, Ryoko Hirakawa, Sunil Sahdeo, Marcos E. Milla, Luca Santarelli, Daniel Bertrand, Dinah Misner, Geoffrey Tombaugh, Tanya L. Wallace, Ken A. Brameld
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 350:455-468
Both preclinical evidence and clinical evidence suggest that α7 nicotinic acetylcholine receptor activation (α7nAChR) improves cognitive function, the decline of which is associated with conditions such as Alzheimer's disease and schizophrenia. Mor
Publikováno v:
Alzheimer's & Dementia. 12
Autor:
Amyaouch Bradaia, Heike Deisemann, Larry Park, Simon Gelman, Esther Steidl, Melanie Gleyzes, Ulrike Dijkman, Celia Dominguez, Leticia Toledo-Sherman, Vinod Khetarpal, Outi Kontkanen, Dirk Winkler, Ioana Neagoe, Robert Freije, Mariette Heins, Taneli Heikkinen, Jukka Puoliväli, Robyn M. Javier, Ladislav Mrzljak, Vahri Beaumont, Geoffrey Tombaugh, Kimmo Lehtimäki, Arash Rassoulpour, Ignacio Munoz-Sanjuan, Andreas Ebneth
Publikováno v:
Experimental neurology. 282
Dysregulation of the kynurenine (Kyn) pathway has been associated with the progression of Huntington's disease (HD). In particular, elevated levels of the kynurenine metabolites 3-hydroxy kynurenine (3-OH-Kyn) and quinolinic acid (Quin), have been re
Autor:
Michael Murray, Luca Santarelli, Daniel Bertrand, David Lowe, Porter Richard Hugh Phillip, Patrick M. Callahan, Alvin V. Terry, Shaojie Wang, W Rowe, Walter Xie, Geoffrey Tombaugh, Tanya L. Wallace, Brian Herbert, Joshua S. Rodefer, Elizabeth Doorly Graham, Ashok Tehim, Voon Ong
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 336:242-253
Neuronal nicotinic α7 acetylcholine receptors (α7nAChRs) are expressed primarily in the brain and are implicated in modulating many cognitive functions (e.g., attention, working and episodic memory). Not surprisingly, much effort has been committed