Výsledky vyhledávání - "Geoffrey T. Yarranton"

Antibodies for the treatment of bacterial infections: current experience and future prospects

Autor: Christopher R. Bebbington, Geoffrey T. Yarranton

Publikováno v: Current Opinion in Biotechnology. 19:613-619

Antibodies can be used for the prevention and treatment of bacterial infections in animal models of disease. Current antibody technology allows the generation of high affinity human/humanized antibodies that can be optimized for antibacterial activit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33091e8d042c0844025f225de8d5211f
https://doi.org/10.1016/j.copbio.2008.10.002

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Inducible vectors for expression in mammalian cells

Autor: Geoffrey T. Yarranton

Publikováno v: Current Opinion in Biotechnology. 3:506-511

The most recent developments in mammalian cell inducible expression systems have involved the use of bacterial gene control elements and viral transactivator proteins. The combination of hybrid viral transactivator and bacterial repressor proteins, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fae3bac3d87e72b453c60fcd8641f2
https://doi.org/10.1016/0958-1669(92)90078-w

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CD10 is a key enzyme involved in the activation of tumor-activated peptide prodrug CPI-0004Na and novel analogues: implications for the design of novel peptide prodrugs for the therapy of CD10+ tumors

Autor: Chin, Pan, Pina M, Cardarelli, Matthew H, Nieder, Lesley B, Pickford, Sanjeev, Gangwar, David J, King, Geoffrey T, Yarranton, Dana, Buckman, William, Roscoe, Fengmin, Zhou, Adam, Salles, Tseng-Hui, Chen, Killian, Horgan, Yi-Hong, Wang, Thi, Nguyen, Christopher R, Bebbington

Publikováno v: Cancer research. 63(17)

Traditional chemotherapeutic drugs are often restricted by severe side effects and lack of tumor specificity. Peptide prodrugs cleavable by peptidases present in the tumor environment have been explored to improve the therapeutic index of cytotoxic d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eab94ba6b423e37507b195fc161f225b
https://pubmed.ncbi.nlm.nih.gov/14500390

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CPI-0004Na, a new extracellularly tumor-activated prodrug of doxorubicin: in vivo toxicity, activity, and tissue distribution confirm tumor cell selectivity

Autor: Vincent, Dubois, Luc, Dasnois, Karim, Lebtahi, Françoise, Collot, Nathalie, Heylen, Nathalie, Havaux, Anne-Marie, Fernandez, Thomas J, Lobl, Cecilia, Oliyai, Matthew, Nieder, Dan, Shochat, Geoffrey T, Yarranton, André, Trouet

Publikováno v: Cancer research. 62(8)

The search for cancer therapies that are more selective for tumor cells and spare normal sensitive cells has been very active for at least 20 years. The extracellularly tumor-activated peptidic prodrug of doxorubicin (Dox) CPI-0004Na (N-succinyl-beta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9f6120dd02ee3e538f8fd959cffb60e7
https://pubmed.ncbi.nlm.nih.gov/11956091

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Granulocyte-Macrophage Colony-Stimulating Factor Antibody Improves Left Ventricular Function and Limits Maladaptive Remodeling Following Myocardial Infarction

Autor: Robert S. Kellar, Nicholle M. Johnson, Maribeth Stansifer, Christopher R. Bebbington, Howard G. Byrne, Hoang M. Thai, Jordan J. Lancaster, Elizabeth Juneman, Geoffrey T. Yarranton, Steven Goldman

Publikováno v: Journal of Cardiac Failure. 14:S41-S42

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc1f2af303a82ec1bfcc7be5d88fdff8
https://doi.org/10.1016/j.cardfail.2008.06.292

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A Phase I Study Of KB004, a Novel Non-Fucosylated humaneered® Antibody, Targeted Against The Receptor Tyrosine Kinase EphA3, In Advanced Hematologic Malignancies

Autor: Andrew H. Wei, Brian A. Jonas, Simon Durrant, Ronan T. Swords, Jackie M. Walling, Jeffrey E. Lancet, Jorge E. Cortes, Ian D. Lewis, Mark Hertzberg, Geoffrey T. Yarranton

Publikováno v: Blood. 122:3838-3838

Background EphA3 is involved in cell positioning in fetal development. In the adult it is an oncofetal antigen re-expressed in hematologic malignancies (blood and bone marrow, leukemic stem cells) and solid tumors (tumor stem cells, neovasculature an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28ff8bfc00e50fafaba62a0e5b223eec
https://doi.org/10.1182/blood.v122.21.3838.3838

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Analysis Of EphA3 Expression In Hematologic Malignancies By Quantitative PCR

Autor: Jeffrey L. Jorgensen, Pramoda Challagundla, Geoffrey T. Yarranton, Jairo Matthews, Farhad Ravandi, Gautam Borthakur, Jennifer C. Ho, Naveen Pemmaraju, Hagop M. Kantarjian, Jorge E. Cortes, John Woronicz, Jackie M. Walling

Publikováno v: Blood. 122:4981-4981

EphA3 is a receptor tyrosine kinase that plays an important role in cell positioning and tissue organization during fetal development, but is not thought to play a significant role in healthy adults. However, aberrant EphA3 expression has been report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5709d111198141709f435d0962e1a71a
https://doi.org/10.1182/blood.v122.21.4981.4981

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Preclinical Characterization of KB003, a Novel Humaneered™ Monoclonal Anti-GM-CSF Antibody, Demonstrates That the GM-CSF Signaling Axis Is a Therapeutic Target in Chronic Myelomonocytic Leukemia (CMML)

Autor: Mark Baer, Jessica M. McDaniel, Adam W. Mailloux, Pearlie K. Epling-Burnette, Alan F. List, Jeffrey E. Lancet, Geoffrey T. Yarranton, Rami S. Komrokji, Christopher R. Bebbington, Jeffrey S. Painter, Eric Padron, Kathy L. McGraw

Publikováno v: Blood. 120:3793-3793

Abstract 3793 Introduction: Chronic Myelomonocytic Leukemia (CMML) is a genetically diverse hematologic malignancy characterized by cytopenias with or without leukocytosis, marrow dysplasia, monocytosis, splenomegaly, and a propensity to transform to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ecc473f7f4fcf6ccd5caba7eaedd4ef
https://doi.org/10.1182/blood.v120.21.3793.3793

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A DNA Polymerase from Ustilago maydis. 2. Properties of the Associated Deoxyribonuclease Activity

Autor: Geoffrey R. Banks, Geoffrey T. Yarranton

Publikováno v: European Journal of Biochemistry. 62:143-150

The polymerase and deoxyribonuclease activities of the purified Ustilago maydis DNA polymerase coeluted from a hydroxyapatite column, cosedimented in sucrose gradients in both the absence and presence of salt, possessed similar thermolabilities and r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75c9d70e5583b884714421c9a472f0a0
https://doi.org/10.1111/j.1432-1033.1976.tb10107.x

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