Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Geoffrey T. Yarranton"'
Autor:
Milena S. Espindola, David M. Habiel, Isabelle Jones, Cory M. Hogaboam, Rohan Narayanan, John Woronicz, Geoffrey T. Yarranton, Ana Lucia Coelho
Publikováno v:
QJM: An International Journal of Medicine.
Publikováno v:
Current Opinion in Biotechnology. 19:613-619
Antibodies can be used for the prevention and treatment of bacterial infections in animal models of disease. Current antibody technology allows the generation of high affinity human/humanized antibodies that can be optimized for antibacterial activit
Autor:
Geoffrey T. Yarranton
Publikováno v:
Current Opinion in Biotechnology. 3:506-511
The most recent developments in mammalian cell inducible expression systems have involved the use of bacterial gene control elements and viral transactivator proteins. The combination of hybrid viral transactivator and bacterial repressor proteins, a
Autor:
Chin, Pan, Pina M, Cardarelli, Matthew H, Nieder, Lesley B, Pickford, Sanjeev, Gangwar, David J, King, Geoffrey T, Yarranton, Dana, Buckman, William, Roscoe, Fengmin, Zhou, Adam, Salles, Tseng-Hui, Chen, Killian, Horgan, Yi-Hong, Wang, Thi, Nguyen, Christopher R, Bebbington
Publikováno v:
Cancer research. 63(17)
Traditional chemotherapeutic drugs are often restricted by severe side effects and lack of tumor specificity. Peptide prodrugs cleavable by peptidases present in the tumor environment have been explored to improve the therapeutic index of cytotoxic d
Autor:
Vincent, Dubois, Luc, Dasnois, Karim, Lebtahi, Françoise, Collot, Nathalie, Heylen, Nathalie, Havaux, Anne-Marie, Fernandez, Thomas J, Lobl, Cecilia, Oliyai, Matthew, Nieder, Dan, Shochat, Geoffrey T, Yarranton, André, Trouet
Publikováno v:
Cancer research. 62(8)
The search for cancer therapies that are more selective for tumor cells and spare normal sensitive cells has been very active for at least 20 years. The extracellularly tumor-activated peptidic prodrug of doxorubicin (Dox) CPI-0004Na (N-succinyl-beta
Autor:
Robert S. Kellar, Nicholle M. Johnson, Maribeth Stansifer, Christopher R. Bebbington, Howard G. Byrne, Hoang M. Thai, Jordan J. Lancaster, Elizabeth Juneman, Geoffrey T. Yarranton, Steven Goldman
Publikováno v:
Journal of Cardiac Failure. 14:S41-S42
Autor:
Jeffrey L. Jorgensen, Pramoda Challagundla, Geoffrey T. Yarranton, Jairo Matthews, Farhad Ravandi, Gautam Borthakur, Jennifer C. Ho, Naveen Pemmaraju, Hagop M. Kantarjian, Jorge E. Cortes, John Woronicz, Jackie M. Walling
Publikováno v:
Blood. 122:4981-4981
EphA3 is a receptor tyrosine kinase that plays an important role in cell positioning and tissue organization during fetal development, but is not thought to play a significant role in healthy adults. However, aberrant EphA3 expression has been report
Autor:
Andrew H. Wei, Brian A. Jonas, Simon Durrant, Ronan T. Swords, Jackie M. Walling, Jeffrey E. Lancet, Jorge E. Cortes, Ian D. Lewis, Mark Hertzberg, Geoffrey T. Yarranton
Publikováno v:
Blood. 122:3838-3838
Background EphA3 is involved in cell positioning in fetal development. In the adult it is an oncofetal antigen re-expressed in hematologic malignancies (blood and bone marrow, leukemic stem cells) and solid tumors (tumor stem cells, neovasculature an
Autor:
Mark Baer, Jessica M. McDaniel, Adam W. Mailloux, Pearlie K. Epling-Burnette, Alan F. List, Jeffrey E. Lancet, Geoffrey T. Yarranton, Rami S. Komrokji, Christopher R. Bebbington, Jeffrey S. Painter, Eric Padron, Kathy L. McGraw
Publikováno v:
Blood. 120:3793-3793
Abstract 3793 Introduction: Chronic Myelomonocytic Leukemia (CMML) is a genetically diverse hematologic malignancy characterized by cytopenias with or without leukocytosis, marrow dysplasia, monocytosis, splenomegaly, and a propensity to transform to
Publikováno v:
European Journal of Biochemistry. 62:143-150
The polymerase and deoxyribonuclease activities of the purified Ustilago maydis DNA polymerase coeluted from a hydroxyapatite column, cosedimented in sucrose gradients in both the absence and presence of salt, possessed similar thermolabilities and r