Výsledky vyhledávání - "Geoffrey R Guile"

Akademický článek

The contribution of diet and genotype to iron status in women: a classical twin study.

Autor: Susan J Fairweather-Tait, Geoffrey R Guile, Ana M Valdes, Anna A Wawer, Rachel Hurst, Jane Skinner, Alexander J Macgregor

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e83047 (2013)

This is the first published report examining the combined effect of diet and genotype on body iron content using a classical twin study design. The aim of this study was to determine the relative contribution of genetic and environmental factors in d

Externí odkaz: https://doaj.org/article/3365bee48cfb426ea6cc377cfc45065b

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Concurrent oral 3 - Environmental and genetic factors: OP16. In Patients with Early Inflammatory Polyarthritis, Younger Age, Acpa Positivity, Shared Epitope, And Inefficacy of the First Dmard are Associated with the Need to Start a Biological Therapy: Results from the Norfolk Arthritis Register (NOAR)

Publikováno v: Rheumatology. 50:iii37-iii39

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c0ffeb08d0fbbc2c8d7e452b9198a4a
https://doi.org/10.1093/rheumatology/ker071

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Sialylated N-glycans in adult rat brain tissue. A widespread distribution of disialylated antennae in complex and hybrid structures

Autor: Susanne Zamze, David Harvey, Yi-Ju Chen, Geoffrey R. Guile, David R. Wing, Raymond A. Dwek

Publikováno v: European Journal of Biochemistry. 258:243-270

This paper extends our earlier work on the analysis of neutral N-glycans from adult rat brain to glycans carrying NeuAc residues as their sole charged groups. These structures comprised at least 40% of the total (acidic and neutral) N-glycan pool. Co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbab20ca8921f32a4962410e13195375
https://doi.org/10.1046/j.1432-1327.1998.2580243.x

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The contribution of diet and genotype to iron status in women: a classical twin study

Autor: Rachel Hurst, Anna A. Wawer, Ana M. Valdes, Geoffrey R. Guile, Susan J. Fairweather-Tait, Jane Skinner, Alex J. MacGregor

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e83047 (2013)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab359d2aa5abef0e8af54751fc190d8
http://europepmc.org/articles/PMC3876997?pdf=render

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Synthetic glycosylation of proteins using N-(β-saccharide) iodoacetamides: applications in site-specific glycosylation and solid-phase enzymic oligosaccharide synthesis

Autor: G. Arsequell, Raymond A. Dwek, S. Y. C. Wong, Geoffrey R. Guile

Publikováno v: Biochemical Journal. 300:843-850

A simple and efficient synthetic glycosylation method suitable for use in solid-phase enzymic oligosaccharide synthesis and site-specific glycosylation of recombinant proteins to produce defined glycoforms is described. This strategy utilizes N-(beta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29953be6d32d479d668c1a999d0373b1
https://doi.org/10.1042/bj3000843

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Diet and bone mineral density study in postmenopausal women from the TwinsUK registry shows a negative association with a traditional English dietary pattern and a positive association with wine

Autor: Jane Skinner, Susan J. Fairweather-Tait, Geoffrey R. Guile, Alex J. MacGregor, Tim D. Spector, Aedin Cassidy

Publikováno v: The American journal of clinical nutrition. 94(5)

Background: The effect of diet on bone mineral density (BMD) remains controversial, mainly because of difficulties in isolating dietary factors from the confounding influences of age, lifestyle, and genetic factors. Objective: The aim of this study w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6585f83b17ac129b564f9cf470ba92c0
https://pubmed.ncbi.nlm.nih.gov/21940596

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Factors affecting boosting ensemble performance on DNA microarray data

Autor: Wenjia Wang, Geoffrey R. Guile

Publikováno v: IJCNN

Boosting techniques have been applied to DNA microarray data because their high dimensionality has made them difficult to analyze. However, classification performance varies between boosting algorithms. We have investigated factors affecting error in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5293db8827ea115268350992fb540a9e
https://doi.org/10.1109/ijcnn.2010.5596600

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Degradome expression profiling in human articular cartilage

Autor: A. Cooper, Jasmine G. Waters, Wenjia Wang, Tracey E. Swingler, Simon T. Donell, Caroline J. Pennington, Geoffrey R. Guile, C. Darrah, R.K. Davidson, Ian M. Clark, Xose S. Puente

Publikováno v: Arthritis Research & Therapy
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RUO. Repositorio Institucional de la Universidad de Oviedo
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Introduction The molecular mechanisms underlying cartilage destruction in osteoarthritis are poorly understood. Proteolysis is a key feature in the turnover and degradation of cartilage extracellular matrix where the focus of research has been on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35393dbd069b464a4eb4d57585319533
https://pubmed.ncbi.nlm.nih.gov/19549314

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Boosting for feature selection for microarray data analysis

Autor: Geoffrey R. Guile, Wenjia Wang

Publikováno v: IJCNN

We have investigated the use of boosting techniques for feature selection for microarray data analysis. We propose a novel algorithm for feature selection and have tested it on three datasets. The results clearly show that our boosting technique for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0725ed73e02ee800d3d2c9bf4e7cf1ad
https://doi.org/10.1109/ijcnn.2008.4634156

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Enhancing Boosting by Feature Non-Replacement for Microarray Data Analysis

Autor: Wenjia Wang, Geoffrey R. Guile

Publikováno v: IJCNN

We have investigated strategies for enhancing ensemble learning algorithms for DNA microarray data analysis. By using modified versions of AdaBoost, LogitBoost and BagBoosting we have shown that feature non-replacement provides an effective enhanceme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2e0b6f9250e90f96c21679427787ff9
https://doi.org/10.1109/ijcnn.2007.4370995

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