Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Geoffrey Quinque"'
Autor:
Yong Jiang, Tia Lewis, Patricia M. McCormick, Michael Schaber, Beth Pietrak, Rachel D. Totoritis, Marc A. Holbert, Lawrence M. Szewczuk, Daniel Fornwald, William G. Bonnette, Geoffrey Quinque, Maggie Grimes, Rosalie E. Matico, Ed Dul, Randy K. Bledsoe, Derrick W. Meinhold, Stephanie Chen
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
Significant resource is spent by drug discovery project teams to generate numerous, yet unique target constructs for the multiple platforms used to drive drug discovery programs including: functional assays, biophysical studies, structural biology, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1b0cbe26de02a861c13c08b95ac2b93
http://link.springer.com/article/10.1038/s41598-019-49149-2
http://link.springer.com/article/10.1038/s41598-019-49149-2
Autor:
Pan F. Chan, Kaushik Raha, Shruti Jain, Geoffrey Quinque, Margarete Neu, Daniele Andreotti, Roberto Profeta, Reema K. Thalji, Brian Donovan, Simona Tommasi, Lynn McCloskey, Christopher J. Nixon, Giovanni Meneghelli, Tania Bakshi, Anna Checchia, Robert A. Stavenger, Benjamin D. Bax, Alison Howells, Federica Tonelli, Haifeng Cui
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1407-1412
A series of DNA gyrase inhibitors were designed based on the X-ray structure of a parent thiophene scaffold with the objective to improve biochemical and whole-cell antibacterial activity, while reducing cardiac ion channel activity. The binding mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f63ff5d1f9eeb44a22b39b1dba435047
https://doi.org/10.1016/j.bmcl.2019.03.029
https://doi.org/10.1016/j.bmcl.2019.03.029
Autor:
William G. Bonnette, Jeffrey W. Gross, Geoffrey Quinque, Ann F. Hoffman, Lawrence M. Szewczuk, Yong Jiang, Marc A. Holbert
Publikováno v:
Analytical biochemistry. 559
Aggregated compounds can promiscuously and nonspecifically associate with proteins resulting in either false inhibition or activation of many different protein target classes. We developed a high-content imaging assay in a 384-well format using fluor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5747e7249f452482c34062338b410b7
https://pubmed.ncbi.nlm.nih.gov/30142329
https://pubmed.ncbi.nlm.nih.gov/30142329