Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Geoffrey McCowage"'
Autor:
Chelsea Mayoh, Andrew J. Gifford, Rachael Terry, Loretta M. S. Lau, Marie Wong, Padmashree Rao, Tyler Shai-Hee, Federica Saletta, Dong-Anh Khuong-Quang, Vicky Qin, Marion K. Mateos, Deborah Meyran, Katherine E. Miller, Aysen Yuksel, Emily V. A. Mould, Rachel Bowen-James, Dinisha Govender, Akanksha Senapati, Nataliya Zhukova, Natacha Omer, Hetal Dholaria, Frank Alvaro, Heather Tapp, Yonatan Diamond, Luciano Dalla Pozza, Andrew S. Moore, Wayne Nicholls, Nicholas G. Gottardo, Geoffrey McCowage, Jordan R. Hansford, Seong-Lin Khaw, Paul J. Wood, Daniel Catchpoole, Catherine E. Cottrell, Elaine R. Mardis, Glenn M. Marshall, Vanessa Tyrrell, Michelle Haber, David S. Ziegler, Orazio Vittorio, Joseph A. Trapani, Mark J. Cowley, Paul J. Neeson, Paul G. Ekert
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-18 (2023)
Abstract Background Molecular profiling of the tumour immune microenvironment (TIME) has enabled the rational choice of immunotherapies in some adult cancers. In contrast, the TIME of paediatric cancers is relatively unexplored. We speculated that a
Externí odkaz:
https://doaj.org/article/fbd7979e6f4b4aebb70a711623639d1f
Autor:
Sarah M. Trinder, Campbell McKay, Phoebe Power, Monique Topp, Bosco Chan, Santosh Valvi, Geoffrey McCowage, Dinisha Govender, Maria Kirby, David S. Ziegler, Neevika Manoharan, Tim Hassall, Stewart Kellie, John Heath, Frank Alvaro, Paul Wood, Stephen Laughton, Karen Tsui, Andrew Dodgshun, David D. Eisenstat, Raelene Endersby, Stephen J. Luen, Eng-Siew Koh, Hao-Wen Sim, Benjamin Kong, Nicholas G. Gottardo, James R. Whittle, Dong-Anh Khuong-Quang, Jordan R. Hansford
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
The mitogen-activated protein kinase (MAPK) pathway signaling pathway is one of the most commonly mutated pathways in human cancers. In particular, BRAF alterations result in constitutive activation of the rapidly accelerating fibrosarcoma–extracel
Externí odkaz:
https://doaj.org/article/b70dc0b5bc9c4f5f8e61a5acca858e20
Autor:
Toby Trahair, Geoffrey McCowage, Maria Schaffer, Jamie I. Fletcher, Ursula M Sansom-Daly, Jennifer Buchhorn-White, Glenn M. Marshall, Antoinette Anazodo, Michael Evtushenko, Sarah J. Ellis, Clarissa E. Schilstra, Joanna E. Fardell
Publikováno v:
Journal of Adolescent and Young Adult Oncology. 11:211-222
Purpose: Involvement of adolescent and young adult (AYAs) cancer survivors as consumers in research is increasingly encouraged, yet few studies have identified the feasibility and acceptability of ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ebb89a49bea0cdb2fb33baaf09f80b7
https://doi.org/10.1089/jayao.2021.0052
https://doi.org/10.1089/jayao.2021.0052
Autor:
Smadar Kahana-Edwin, James Torpy, Lucy E. Cain, Anna Mullins, Geoffrey McCowage, Sarah E. Woodfield, Sanjeev A. Vasudevan, Dan P.T. Shea, Andre E Minoche, Sarah Kummerfeld, Leonard D. Goldstein, Jonathan Karpelowsky
Driver mutations in CTNNB1 are a hallmark of hepatoblastoma and offer a common biomarker for a liquid biopsy approach based on the presence of CTNNB1 circulating tumor DNA (ctDNA). We developed and investigated the utility of a quantitative universal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc6fead0d64f60d29ff564abe6763047
https://doi.org/10.1101/2022.09.20.22279947
https://doi.org/10.1101/2022.09.20.22279947
Autor:
Chelsea Mayoh, Andrew J Gifford, Rachael Terry, Loretta MS Lau, Marie Wong, Padmashree Rao, Tyler Shai-Hee, Federica Saletta, Dong-Anh Khuong-Quang, Vicky Qin, Marion Mateos, Deborah Meyran, Katherine E Miller, Aysen Yuksel, Emily VA Mould, Rachael Bowen-James, Dinisha Govender, Akanksha Senapati, Nataliya Zhukova, Natacha Omer, Hetal Dholaria, Frank Alvaro, Heather Tapp, Yonatan Diamond, Luciano Dalla Pozza, Andrew S Moore, Wayne Nicholls, Nicholas G Gottardo, Geoffrey McCowage, Jordan R Hansford, Seong-Lin Khaw, Paul J Wood, Daniel Catchpoole, Catherine E Cottrell, Elaine R Mardis, Glenn M Marshall, Vanessa Tyrrell, Michelle Haber, David S Ziegler, Orazio Vittorio, Joseph A Trapani, Mark J Cowley, Paul J Neeson, Paul G Ekert
Background Molecular profiling of the tumour immune microenvironment (TIME) has enabled the rational choice of immunotherapies in some adult cancers. In contrast, the TIME of paediatric cancers is relatively unexplored. We speculated that a more refi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340c3b6ed6b6d88bca6d53a91379c378
https://doi.org/10.1101/2022.09.16.508179
https://doi.org/10.1101/2022.09.16.508179
Autor:
Marguerite T. Parisi, Lisa A. Teot, Pooja Hingorani, Yueh-Yun Chi, William H. Meyer, Douglas J. Harrison, Geoffrey McCowage, Douglas S. Hawkins, Andrea Hayes-Jordan, Barry L. Shulkin, Torunn I. Yock, Suzanne L. Wolden, Rajkumar Venkatramani, Brenda J. Weigel, Jing Tian, David A. Rodeberg, Leo Mascarenhas, Sheri L. Spunt
Publikováno v:
Cancer Medicine. 10:857-866
Background Strategies to optimize management in rhabdomyosarcoma (RMS) include risk stratification to assign therapy aiming to minimize treatment morbidity yet improve outcomes. This analysis evaluated the relationship between complete metabolic resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::556156c8af52e6df3874b41f6e0bccf1
https://doi.org/10.1002/cam4.3667
https://doi.org/10.1002/cam4.3667
Autor:
Shiloh Middlemiss, Kenneth Hsu, Geoffrey McCowage, Belinda Kramer, Federica Saletta, Stephen Gottschalk
Publikováno v:
Cancer Gene Ther
Chimeric Antigen Receptor (CAR) T-cell therapy, as an approved treatment option for patients with B cell malignancies, demonstrates that genetic modification of autologous immune cells is an effective anti-cancer regimen. Erythropoietin-producing Hep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6534c47ce7bc810584e5457a9a1b80e2
https://doi.org/10.1038/s41417-020-00221-4
https://doi.org/10.1038/s41417-020-00221-4
Autor:
Evangeline Jackson, Ryan Duchatel, Mika Persson, Abdul Mannan, Sridevi Yadavilli, Sarah Parackal, Shaye Game, Wai Chin Chong, Samantha Jayasekara, Marion Le Grand, Padraic Kearney, Alicia Douglas, Izac Findlay, Dilana Staudt, Zacary Germon, David Skerrett-Byrne, Brett Nixon, Nathan Smith, Esther Hulleman, Bryan Day, Geoffrey McCowage, Frank Alvaro, Sebastian Waszak, Martin Larsen, Yolanda Colino-Sanguino, Fatima Valdes-Mora, Andria Rakotomalala, Samuel Meignan, Eddy Pasquier, Nicholas Vitanza, Javad Nazarian, Carl Koschmann, Jason Cain, Sabine Mueller, Matthew Dun
Publikováno v:
Neuro-Oncology. 24:vii211-vii211
Diffuse midline gliomas (DMGs), including those of the pons (diffuse intrinsic pontine glioma - DIPG), are pediatric CNS tumors recognized as the most lethal of all children’s cancers. Palliative radiotherapy remains the only approved treatment, wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8262a2e661b2e5e78a50f2d2ac3c06cb
https://doi.org/10.1093/neuonc/noac209.811
https://doi.org/10.1093/neuonc/noac209.811
Autor:
Lindsay Kilburn, Daniel Landi, Sarah Leary, David Ziegler, Patricia Baxter, Andrea Franson, Geoffrey McCowage, Angela Waanders, Jasper Van der Lugt, Michal Yalon Oren, Nicolas Gerber, Nicholas Gottardo, Dong-Anh Khuong-Quang, Karsten Nysom, Simon Bailey, Pablo Hernáiz Driever, Sebastien Perreault, Olaf Witt, Seungmin Hahn, Darren Hargrave, Timothy Hassall, Nada Jabado, Hyoung Jin Kang, Valerie Larouche, Helen Toledano, Cassie Kline, Mohamed Abdelbaki, Susan Chi, Sharon Gardner, Nicholas Whipple, Sabine Mueller, Samuel Blackman, Xin Zhao, Daniel Da Costa, Michael Cox, Roger Packer, Jordan Hansford
Publikováno v:
Neuro-Oncology. 24:vii89-vii89
BACKGROUND RAF alterations are oncogenic drivers found in most pediatric low-grade gliomas (LGGs). Tovorafenib is an investigational, oral, selective, CNS-penetrant, small molecule, type II pan‑RAF inhibitor. METHODS FIREFLY-1 (NCT04775485) is a mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::426f6d1ca8e4efd778f33b3866d14c09
https://doi.org/10.1093/neuonc/noac209.333
https://doi.org/10.1093/neuonc/noac209.333
Autor:
Beryl Lin, Adam Jaffe, Hiran Selvadurai, Kate Hardaker, Paul Robinson, Luciano Dalla-Pozza, Leanne Plush, Jamie McBride, Emma Coward, Geoffrey McCowage, Anthea Ng, Toby Trahair, Brendan Kennedy, John Widger
Publikováno v:
Pediatric Pulmonology
Background Respiratory viruses are a common cause of infection in immunosuppressed children undergoing cancer therapy. Pulmonary sequelae have been documented following respiratory viral infections (RVIs) in hematopoietic stem cell transplant (HSCT)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9034ab899ab0603c70018deefa1577
https://doi.org/10.1002/ppul.24456
https://doi.org/10.1002/ppul.24456