Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Geoffrey M. Nelson"'
Autor:
Umut Berkay Altıntaş, Ji-Heui Seo, Claudia Giambartolomei, Dogancan Ozturan, Brad J. Fortunato, Geoffrey M. Nelson, Seth R. Goldman, Karen Adelman, Faraz Hach, Matthew L. Freedman, Nathan A. Lack
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Androgen receptor (AR)-mediated transcription plays a critical role in development and prostate cancer growth. AR drives gene expression by binding to thousands of cis-regulatory elements (CRE) that loop to hundreds of target promoters. With
Externí odkaz:
https://doaj.org/article/93ab95dbf1754e2ab49cc69bd6f1d784
Autor:
Emily G. Kaye, Kavyashree Basavaraju, Geoffrey M. Nelson, Helena D. Zomer, Debarun Roy, Irene Infancy Joseph, Reza Rajabi-Toustani, Huanyu Qiao, Karen Adelman, Prabhakara P. Reddi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Male germ cell development requires precise regulation of gene activity in a cell-type and stage-specific manner, with perturbations in gene expression during spermatogenesis associated with infertility. Here, we use steady-state, nascent an
Externí odkaz:
https://doaj.org/article/dde5609169b7435cbf7f1eda489eb40f
Autor:
Sean M. Flynn, Changchun Chen, Murat Artan, Stephen Barratt, Alastair Crisp, Geoffrey M. Nelson, Sew-Yeu Peak-Chew, Farida Begum, Mark Skehel, Mario de Bono
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
IL-17 is a pro-inflammatory molecule that can also regulate neural circuit function. Here the authors use C. elegans to show that the paracaspase MALT-1 lies downstream of IL-17 signaling and regulates many aspects of C. elegans biology, including es
Externí odkaz:
https://doaj.org/article/377402b6f41e4c2d90a5764edd0f5adf
Autor:
Su Wang, Soohyun Lee, Chong Chu, Dhawal Jain, Peter Kerpedjiev, Geoffrey M. Nelson, Jennifer M. Walsh, Burak H. Alver, Peter J. Park
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-15 (2020)
Abstract The three-dimensional conformation of a genome can be profiled using Hi-C, a technique that combines chromatin conformation capture with high-throughput sequencing. However, structural variations often yield features that can be mistaken for
Externí odkaz:
https://doaj.org/article/d548886af16841be8db011de393a0821
Autor:
Elaine M. Oberlick, Matthew G. Rees, Brinton Seashore-Ludlow, Francisca Vazquez, Geoffrey M. Nelson, Neekesh V. Dharia, Barbara A. Weir, Aviad Tsherniak, Mahmoud Ghandi, John M. Krill-Burger, Robin M. Meyers, Xiaofeng Wang, Phil Montgomery, David E. Root, Jake M. Bieber, Sandi Radko, Jaime H. Cheah, C. Suk-Yee Hon, Alykhan F. Shamji, Paul A. Clemons, Peter J. Park, Michael A. Dyer, Todd R. Golub, Kimberly Stegmaier, William C. Hahn, Elizabeth A. Stewart, Stuart L. Schreiber, Charles W.M. Roberts
Publikováno v:
Cell Reports, Vol 28, Iss 9, Pp 2331-2344.e8 (2019)
Summary: Cancer is often seen as a disease of mutations and chromosomal abnormalities. However, some cancers, including pediatric rhabdoid tumors (RTs), lack recurrent alterations targetable by current drugs and need alternative, informed therapeutic
Externí odkaz:
https://doaj.org/article/92a087e67b0f487ba84b47b60011a6bf
Autor:
Emily G. Kaye, Geoffrey M. Nelson, Helena D. Zomer, Debarun Roy, Irene Infancy Joseph, Karen Adelman, Prabhakara P. Reddi
Male germ cell development requires precise regulation of gene activity in a cell-type and stage-specific manner, with perturbations in gene expression during spermatogenesis associated with infertility. Here, we use steady-state, nascent and single-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::671de899a22eed40556c674ccba70b09
https://doi.org/10.1101/2023.05.08.539879
https://doi.org/10.1101/2023.05.08.539879
Autor:
Gongwei Wu, Noriaki Yoshida, Jihe Liu, Xiaoyang Zhang, Tayla B. Heavican-Foral, Huiyun Liu, Geoffrey M. Nelson, Lu Yang, Renee Chen, Marcus Kenneth Jones, Ran Xu, Ajit Johnson Nirmal, Salvia Jain, Catharine Leahy, Kristen Lynn Jones, Kristen E. Stevenson, Wenchao Wu, Abner Louissaint, Lydie Debaize, Wing C. Chan, Shannan Ho Sui, Samuel Ng, Andrew L. Feldman, Matthew Meyerson, Karen Adelman, chun-Wei David Chen, Myles Brown, David M. Weinstock
Publikováno v:
Blood. 140:1696-1697
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce99985bfc744dc869a516042bafd41a
https://doi.org/10.1182/blood-2022-163368
https://doi.org/10.1182/blood-2022-163368
Autor:
Xavier Rambout, Hana Cho, Roméo Blanc, Qing Lyu, Joseph M. Miano, Joe V. Chakkalakal, Geoffrey M. Nelson, Hari K. Yalamanchili, Karen Adelman, Lynne E. Maquat
Publikováno v:
Molecular Cell. 83:186-202.e11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4672ce72c255ff730cf3b74c3ee3a6aa
https://doi.org/10.1016/j.molcel.2022.12.022
https://doi.org/10.1016/j.molcel.2022.12.022
Autor:
Wenchao Wu, Geoffrey M. Nelson, Raphael Koch, Katherine A. Donovan, Radosław P. Nowak, Tayla B. Heavican-Foral, Ajit J. Nirmal, Huiyun Liu, Lei Yang, Jessica Duffy, Foster Powers, Kristen E. Stevenson, Marcus Kenneth Jones, Samuel Y. Ng, Gongwei Wu, Salvia Jain, Ran Xu, Sam Amaka, Christopher Trevisani, Nicholas L. Donaldson, Patrick R. Hagner, Laurence de Leval, Philippe Gaulard, Javeed Iqbal, Anjan Thakurta, Eric S. Fischer, Karen Adelman, David M. Weinstock
Publikováno v:
Blood
Immunomodulatory (IMiD) agents like lenalidomide and pomalidomide induce the recruitment of IKZF1 and other targets to the CRL4CRBN E3 ubiquitin ligase, resulting in their ubiquitination and degradation. These agents are highly active in B-cell lymph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8887ada6a2827f0b7600e9c1b3caf706
https://pubmed.ncbi.nlm.nih.gov/35357480
https://pubmed.ncbi.nlm.nih.gov/35357480
Autor:
Wenqi Xu, Chenxi He, Emily G. Kaye, Jiahui Li, Mandi Mu, Geoffrey M. Nelson, Li Dong, Jiahua Wang, Feizhen Wu, Yujiang Geno Shi, Karen Adelman, Fei Lan, Yang Shi, Hongjie Shen
Publikováno v:
Molecular Cell. 82:1156-1168.e7
N6-methyladenosine (m6A) methylation is co-transcriptionally deposited on mRNA, but a possible role of m6A on transcription remains poorly understood. Here, we demonstrate that the METTL3/METTL14/WTAP m6A methyltransferase complex (MTC) is localized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf62ceadb9467c9ec2024ac17b930b7
https://doi.org/10.1016/j.molcel.2022.02.006
https://doi.org/10.1016/j.molcel.2022.02.006