Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Geoffrey M Cooper"'
Role for Egr1 in the Transcriptional Program Associated with Neuronal Differentiation of PC12 Cells.
Autor:
Kenneth W Adams, Sergey Kletsov, Ryan J Lamm, Jessica S Elman, Steven Mullenbrock, Geoffrey M Cooper
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170076 (2017)
PC12 cells are a well-established model to study how differences in signal transduction duration can elicit distinct cell behaviors. Epidermal growth factor (EGF) activates transient ERK signaling in PC12 cells that lasts 30-60 min, which in turn pro
Externí odkaz:
https://doaj.org/article/4694657aa41d476897bb4514f675c79f
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20150 (2011)
The protein kinase GSK-3 is constitutively active in quiescent cells in the absence of growth factor signaling. Previously, we identified a set of genes that required GSK-3 to maintain their repression during quiescence. Computational analysis of the
Externí odkaz:
https://doaj.org/article/630d80ebbea1492d817c7b4b3b07c1b2
Publikováno v:
Ports 2016.
Port Metro Vancouver, located in the southwestern corner of British Columbia, is Canada’s largest port. Deltaport Container Terminal, at Roberts Bank just south of Vancouver, opened for business in 1997 and was an immediate success. In response to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::458cf93b763e5694479fc57414d88650
https://doi.org/10.1061/9780784479902.073
https://doi.org/10.1061/9780784479902.073
Publikováno v:
Ports 2016.
The Esquimalt Graving Dock (EGD) is located on federal Crown-owned property in Esquimalt Harbour on Vancouver Island, British Columbia, and is managed by the federal custodian Public Works and Government Services Canada (PWGSC). The EGD facility has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81f5249a7d386daeebf703dfce595ec3
https://doi.org/10.1061/9780784479919.069
https://doi.org/10.1061/9780784479919.069
Publikováno v:
Journal of Biological Chemistry. 286:45131-45145
Neuronal differentiation of PC12 cells in response to NGF is a prototypical model in which signal duration determines a biological response. Sustained ERK activity induced by NGF, as compared with transient activity induced by EGF, is critical to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25f27c3f374041bbdd744d7f0982374
https://doi.org/10.1074/jbc.m111.274076
https://doi.org/10.1074/jbc.m111.274076
Autor:
James F. Brennan, Jolyon Terragni, Jose-Luis Medrano, Sean Sepulveda, Swati Banerjee, Julie R. Graham, Gauri Nayak, Geoffrey M. Cooper
Publikováno v:
Journal of Biological Chemistry. 286:36215-36227
Phosphatidylinositol (PI) 3-kinase/Akt signaling plays a critical role in cell proliferation and survival, partly by regulation of FoxO transcription factors. Previous work using global expression profiling indicated that inhibition of PI 3-kinase in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e1dd1a2014267017f7fe6fa55aeb149
https://doi.org/10.1074/jbc.m111.246116
https://doi.org/10.1074/jbc.m111.246116
Immediate-Early and Delayed Primary Response Genes Are Distinct in Function and Genomic Architecture
Autor:
John W. Tullai, Geoffrey M. Cooper, Michael E. Schaffer, Steven Mullenbrock, Gabriel Sholder, Simon Kasif
Publikováno v:
Journal of Biological Chemistry. 282:23981-23995
The transcriptional program induced by growth factor stimulation is classically described in two stages as follows: the rapid protein synthesis-independent induction of immediate-early genes, followed by the subsequent protein synthesis-dependent ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776dae7bf3d42c1b23612a7170f131db
https://doi.org/10.1074/jbc.m702044200
https://doi.org/10.1074/jbc.m702044200
Autor:
Kenneth W. Adams, Geoffrey M. Cooper
Publikováno v:
Journal of Biological Chemistry. 282:6192-6200
Inhibition of translation plays a role in apoptosis induced by a variety of stimuli, but the mechanism by which it promotes apoptosis has not been established. We have investigated the hypothesis that selective degradation of anti-apoptotic regulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b62c25a07a36a17d694dda056196851
https://doi.org/10.1074/jbc.m610643200
https://doi.org/10.1074/jbc.m610643200
Publikováno v:
Journal of Biological Chemistry. 279:20167-20177
We have taken an integrated approach in which expression profiling has been combined with the use of small molecule inhibitors and computational analysis of transcription factor binding sites to characterize regulatory sequences of genes that are tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86f802a3d9180892d2fbe168c8fe92d3
https://doi.org/10.1074/jbc.m309260200
https://doi.org/10.1074/jbc.m309260200
Publikováno v:
Molecular Reproduction and Development. 70:324-332
Whereas most mammalian cells require extracellular signals to suppress apoptosis, preimplantation embryos can survive and develop to the blastocyst stage in defined medium without added serum or growth factors. Since cells of these embryos are capabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7eda6a64e4f372d5ac1b09b59c46037
https://doi.org/10.1002/mrd.20212
https://doi.org/10.1002/mrd.20212