Zobrazeno 1 - 10
of 269
pro vyhledávání: '"Geoffrey M, Thiele"'
Autor:
Aaron D. Schwab, Todd A. Wyatt, Grace Moravec, Geoffrey M. Thiele, Amy J. Nelson, Angela Gleason, Oliver Schanze, Michael J. Duryee, Debra J. Romberger, Ted R. Mikuls, Jill A. Poole
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-16 (2024)
Abstract Background Environmental/occupational exposures cause significant lung diseases. Agricultural organic dust extracts (ODE) and bacterial component lipopolysaccharide (LPS) induce recruited, transitioning murine lung monocytes/macrophages, yet
Externí odkaz:
https://doaj.org/article/679f8daa696f4b38867233ba2722837f
Aconitate decarboxylase 1 mediates the acute airway inflammatory response to environmental exposures
Autor:
Aaron D. Schwab, Amy J. Nelson, Angela M. Gleason, Oliver W. Schanze, Todd A. Wyatt, Dhananjay D. Shinde, Peng Xiao, Vinai C. Thomas, Chittibabu Guda, Kristina L. Bailey, Tammy Kielian, Geoffrey M. Thiele, Jill A. Poole
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundEnvironmental lipopolysaccharide (LPS) and microbial component-enriched organic dusts cause significant lung disease. These environmental exposures induce the recruitment and activation of distinct lung monocyte/macrophage subpopulations in
Externí odkaz:
https://doaj.org/article/086fbe7825ba451eb94481bbeca9982e
Autor:
Daniel Van Kalsbeek, Rebecca Brooks, Dawson Shaver, Ariadne Ebel, Daniel Hershberger, Cynthia Schmidt, Jill A. Poole, Dana P. Ascherman, Geoffrey M. Thiele, Ted R. Mikuls, Bryant R. England
Publikováno v:
ACR Open Rheumatology, Vol 5, Iss 4, Pp 201-226 (2023)
Background Biomarkers have been proposed as tools to aid in the identification and prognostication of interstitial lung disease (ILD) in rheumatoid arthritis (RA). We performed a systematic review of studies evaluating peripheral blood biomarkers and
Externí odkaz:
https://doaj.org/article/378f6499d6a34a70b8dda937b0741f16
Autor:
Nozima Aripova, Michael J. Duryee, Bryant R. England, Carlos D. Hunter, Jack E. Mordeson, Evan M. Ryan, Eric C. Daubach, Debra J. Romberger, Geoffrey M. Thiele, Ted R. Mikuls
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
ObjectivePost-translational protein modifications with malondialdehyde-acetaldehyde (MAA) and citrulline (CIT) are implicated in the pathogenesis of rheumatoid arthritis (RA). Although precise mechanisms have not been elucidated, macrophage-fibroblas
Externí odkaz:
https://doaj.org/article/0365c73536f742548053bf03c1ff0bcc
Autor:
Hannah E. Lomzenski, Geoffrey M. Thiele, Michael J. Duryee, Sheau-Chiann Chen, Fei Ye, Daniel R. Anderson, Ted R. Mikuls, Michelle J. Ormseth
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Patients with rheumatoid arthritis (RA) have increased atherosclerosis; oxidative stress may be a contributor. Oxidative stress produces immunogenic malondialdehyde-acetaldehyde (MAA) protein adducts and anti-MAA antibodies are detectable in
Externí odkaz:
https://doaj.org/article/d574f9ba36ab47a2a9f75bf1ebfd611c
Autor:
Jill A. Poole, Ted R. Mikuls, Geoffrey M. Thiele, Rohit Gaurav, Amy J. Nelson, Michael J. Duryee, Ananya Mitra, Carlos Hunter, Todd A. Wyatt, Bryant R. England, Dana P. Ascherman
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-15 (2022)
Abstract Immunogenetic as well as environmental and occupational exposures have been linked to the development of rheumatoid arthritis (RA), RA-associated lung disease, and other primary lung disorders. Importantly, various inhalants can trigger post
Externí odkaz:
https://doaj.org/article/6715afcf5ca64ddfa7c719475c176126
Autor:
Dylan T. Bergstedt, Wyatt J. Tarter, Ryan A. Peterson, Marie L. Feser, Mark C. Parish, Christopher C. Striebich, M. Kristen Demoruelle, LauraKay Moss, Elizabeth A. Bemis, Jill M. Norris, V. Michael Holers, Jess D. Edison, Geoffrey M. Thiele, Ted R. Mikuls, Kevin D. Deane
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Background/PurposeIn rheumatoid arthritis (RA) autoantibodies including antibodies to citrullinated protein antigens (ACPA) and rheumatoid factor (RF) can be predictive of incident clinical RA. However, there is limited understanding of how antibody
Externí odkaz:
https://doaj.org/article/c55d5c1e5a054515822d35369da9f6ce
Autor:
Yun-Jeong Song, In Ah. Choi, Françoise Meylan, M. Kristen Demoruelle, Taylor Farley, Arianne C. Richard, Eric Hawley, John Botson, Yoo Jin Hong, Eun Young Lee, Sabina R. Mian, Bartlett C. Hamilton, Geoffrey M. Thiele, Ted R. Mikuls, Naveen Gara, Chris D. Ward, Sarah Lamberth, Kevin D. Deane, Theo Heller, Michael M. Ward, David M. Lee, Thi-Sau Migone, William Stohl, James R. O’Dell, Jill M. Norris, V. Michael Holers, Peter Gregersen, Yeong-Wook Song, Richard M. Siegel
Publikováno v:
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-14 (2020)
Abstract Background The tumor necrosis factor (TNF) superfamily cytokine TNF-like protein 1A (TL1A) and its receptor DR3 are essential for diverse animal models of autoimmune disease and may be pathogenic in rheumatoid arthritis (RA). However, the re
Externí odkaz:
https://doaj.org/article/67eda1b4a8ed453b9815ed1b537021d9
Autor:
Amber N. Johnson, Jack R. Harkema, Amy J. Nelson, John D. Dickinson, Julianna Kalil, Michael J. Duryee, Geoffrey M. Thiele, Balawant Kumar, Amar B. Singh, Rohit Gaurav, Sarah C. Glover, Ying Tang, Debra J. Romberger, Tammy Kielian, Jill A. Poole
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-14 (2020)
Abstract Background Environmental organic dust exposures enriched in Toll-like receptor (TLR) agonists can reduce allergic asthma development but are associated with occupational asthma and chronic bronchitis. The TLR adaptor protein myeloid differen
Externí odkaz:
https://doaj.org/article/37b379af598644059ffd603bf05e2d0d
Autor:
Jacob E. Parriott, Jason P. Stewart, D. David Smith, Stephen M. Curran, Christopher D. Bauer, Todd A. Wyatt, Joy A. Phillips, Elizabeth Lyden, Geoffrey M. Thiele, Joseph A. Vetro
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1843 (2022)
Generating long-lived mucosal and systemic antibodies through respiratory immunization with protective antigens encapsulated in nanoscale biodegradable particles could potentially decrease or eliminate the incidence of many infectious diseases, but r
Externí odkaz:
https://doaj.org/article/22f8d29cc9ca470b8233cc086167e0ea