Significant Therapeutic Efficacy with Combined Radioimmunotherapy and Cetuximab in Preclinical Models of Colorectal Cancer

Autor: Vessela, Vassileva, Vineeth, Rajkumar, Mario, Mazzantini, Mathew, Robson, Adam, Badar, Surinder, Sharma, Erik, Årstad, Daniel, Hochhauser, Mark F, Lythgoe, Jane, Kinghorn, Geoffrey M, Boxer, Rosmund Barbara, Pedley

Publikováno v: Journal of Nuclear Medicine. 56:1239-1245

Despite extensive efforts to improve the clinical management of patients with colorectal cancer, approved treatments for advanced disease offer limited survival benefit. Therefore, the identification of novel treatment strategies is essential. We eva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f91173a289fb8b470adb66c62ed994fb
https://doi.org/10.2967/jnumed.115.157362

Texture analysis of (125)I-A5B7 anti-CEA antibody SPECT differentiates metastatic colorectal cancer model phenotypes and anti-vascular therapy response

Autor: Vineeth Rajkumar, Geoffrey M. Boxer, Gary Cook, Mathew Robson, Vicky Goh, Musib Siddique, RB Pedley

Publikováno v: Rajkumar, V, Goh, V J-L, Siddique, M M, Robson, M, Boxer, G, Pedley, R B & Cook, G J R 2015, ' Texture analysis of (125)I-A5B7 anti-CEA antibody SPECT differentiates metastatic colorectal cancer model phenotypes and anti-vascular therapy response. ', BJC: British Journal of Cancer, vol. 112, pp. 1882-1887 . https://doi.org/10.1038/bjc.2015.166
British Journal of Cancer

Background: We aimed to test the ability of texture analysis to differentiate the spatial heterogeneity of 125I-A5B7 anti-carcinoembryonic antigen antibody distribution by nano-single photon emission computed tomography (SPECT) in well-differentiated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e76ded54fe2df5903859214c2f67382d
https://kclpure.kcl.ac.uk/en/publications/1729c1a7-5f44-4ed1-a42d-a820c91d6b19

The Nonuniformity of Antibody Distribution in the Kidney and its Influence on Dosimetry

Autor: Geoffrey M. Boxer, Ethaar El-Emir, Jason L. J. Dearling, A J Green, Aiden A. Flynn, Robert Boden, Richard H. J. Begent, R. Barbara Pedley

Publikováno v: Radiation Research. 159:182-189

The therapeutic efficacy of radiolabeled antibody fragments can be limited by nephrotoxicity, particularly when the kidney is the major route of extraction from the circulation. Conventional dose estimates in kidney assume uniform dose deposition, bu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2342c7e062e83f625ef681161eba92
https://doi.org/10.1667/0033-7587(2003)159[0182:tnoadi]2.0.co

Antibody and radionuclide characteristics and the enhancement of the effectiveness of radioimmunotherapy by selective dose delivery to radiosensitive areas of tumour

Autor: Richard H. J. Begent, RB Pedley, J Bhatia, A J Green, AA Flynn, R Boden, Geoffrey M. Boxer, Richard W Morris

Publikováno v: International Journal of Radiation Biology. 78:407-415

Estimating the absorbed dose to tumour relative to normal tissues has often been used in the assessment of the therapeutic efficacy of radiolabelled antibodies for radioimmunotherapy. Typically, the calculations assume a uniform dose deposition and r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::769242084405b422afa7de4cfe6ee458
https://doi.org/10.1080/09553000110117818

Relationship between tumour morphology, antigen and antibody distribution measured by fusion of digital phosphor and photographic images

Autor: AA Flynn, Geoffrey M. Boxer, R. Barbara Pedley, Richard H. J. Begent

Publikováno v: Cancer Immunology, Immunotherapy. 50:77-81

Antibody-directed cancer therapy has achieved encouraging responses despite poor localisation in tumour. This discrepancy may be attributed to heterogeneity of antibody delivery within tumours: preferential localisation in the better perfused and mor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860aa56592207815dfacdc2b94390189
https://doi.org/10.1007/s002620100176