Zobrazeno 1 - 10
of 251
pro vyhledávání: '"Geoffrey L. Hammond"'
Autor:
Anne Mette Frøbert, Malene Brohus, Julia N. C. Toews, Phillip Round, Ole Fröbert, Geoffrey L. Hammond, Michael T. Overgaard
Publikováno v:
FEBS Open Bio, Vol 12, Iss 2, Pp 362-378 (2022)
Sex hormone‐binding globulin (SHBG) regulates the bioavailability of sex steroid hormones in the blood. Levels of SHBG increase markedly in brown bears (Ursus arctos) during hibernation, suggesting that a key regulatory role of this protein is to q
Externí odkaz:
https://doaj.org/article/f2379c4d55404729b36ee92d852dd718
Autor:
Zoe C. Johnston, Michelle Bellingham, Panagiotis Filis, Ugo Soffientini, Denise Hough, Siladitya Bhattacharya, Marc Simard, Geoffrey L. Hammond, Peter King, Peter J. O’Shaughnessy, Paul A. Fowler
Publikováno v:
BMC Medicine, Vol 16, Iss 1, Pp 1-16 (2018)
Abstract Background Human fetal adrenal glands are highly active and, with the placenta, regulate circulating progesterone, estrogen and corticosteroids in the fetus. At birth the adrenals are essential for neonate salt retention through secretion of
Externí odkaz:
https://doaj.org/article/884a4e21a4714467b1d19fd81a10cfae
Autor:
Jeremy M. Van Raamsdonk, Zoe Murphy, David M. Selva, Reza Hamidizadeh, Jacqueline Pearson, Ǻsa Petersén, Maria Björkqvist, Cameron Muir, Ian R. Mackenzie, Geoffrey L. Hammond, A. Wayne Vogl, Michael R. Hayden, Blair R. Leavitt
Publikováno v:
Neurobiology of Disease, Vol 26, Iss 3, Pp 512-520 (2007)
Huntington disease (HD) is an adult onset, neurodegenerative disorder that results from CAG expansion in the HD gene. Recent work has demonstrated testicular degeneration in mouse models of HD and alterations in the hypothalamic–pituitary–gonadal
Externí odkaz:
https://doaj.org/article/09a8aa9698d34adcb48fd9923102c745
Autor:
David M. Selva, Veronica Hirsch-Reinshagen, Braydon Burgess, Steven Zhou, Jeniffer Chan, Sean McIsaac, Michael R. Hayden, Geoffrey L. Hammond, A. Wayne Vogl, Cheryl L. Wellington
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 6, Pp 1040-1050 (2004)
The liver X receptor/retinoid X receptor (LXR/RXR)-regulated gene ABCA1 effluxes cellular cholesterol and phospholipid to apolipoprotein A1 (apoA1), which is the rate-limiting step in high-density lipoprotein synthesis. The RXR pathway plays a critic
Externí odkaz:
https://doaj.org/article/c7ec9127b9b549cf8a4567251e286d7f
Autor:
Lesley A Hill, Zeynep Sumer-Bayraktar, John G Lewis, Eva Morava, Morten Thaysen-Andersen, Geoffrey L Hammond
Publikováno v:
Endocrine Connections, Vol 8, Iss 8, Pp 1136-1148 (2019)
Objective: Discrepancies in ELISA measurements of human corticosteroid-binding globulin (CBG) using detection monoclonal antibodies that recognize an epitope (9G12) within its reactive center loop (RCL), versus an epitope (12G2) in a different locati
Externí odkaz:
https://doaj.org/article/b1f4b1171610499aa046afff22157cdc
Autor:
Julia N C Toews, Tristan J Philippe, Lesley A Hill, Matthew Dordevic, Allende Miguelez-Crespo, Natalie Z M Homer, Mark Nixon, Geoffrey L Hammond, Victor Viau
Publikováno v:
Endocrinology. 163
Encoded by SerpinA6, plasma corticosteroid-binding globulin (CBG) transports glucocorticoids and regulates their access to cells. We determined how CBG influences plasma corticosterone and adrenal development in rats during the pubertal to adult tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b530312147d54123b580da1e4cc7cf22
https://doi.org/10.1210/endocr/bqac152
https://doi.org/10.1210/endocr/bqac152
Autor:
Anne Mette Frøbert, Julia N. C. Toews, Claus G. Nielsen, Malene Brohus, Jonas Kindberg, Niels Jessen, Ole Fröbert, Geoffrey L. Hammond, Michael T. Overgaard
Publikováno v:
Frøbert, A M, Toews, J N C, Nielsen, C G, Brohus, M, Kindberg, J, Jessen, N, Fröbert, O, Hammond, G L & Overgaard, M T 2022, ' Differential Changes in Circulating Steroid Hormones in Hibernating Brown Bears : Preliminary Conclusions and Caveats ', Physiological and Biochemical Zoology, vol. 95, no. 5, pp. 365-378 . https://doi.org/10.1086/721154
Frøbert, A M, Toews, J N C, Nielsen, C G, Brohus, M, Kindberg, J, Jessen, N, Fröbert, O, Hammond, G L & Overgaard, M T 2022, ' Differential Changes in Circulating Steroid Hormones in Hibernating Brown Bears : Preliminary Conclusions and Caveats ', Physiological and Biochemical Zoology, vol. 95, no. 5, pp. 366-378 . https://doi.org/10.1086/721154
Frøbert, A M, Toews, J N C, Nielsen, C G, Brohus, M, Kindberg, J, Jessen, N, Fröbert, O, Hammond, G L & Overgaard, M T 2022, ' Differential Changes in Circulating Steroid Hormones in Hibernating Brown Bears : Preliminary Conclusions and Caveats ', Physiological and Biochemical Zoology, vol. 95, no. 5, pp. 366-378 . https://doi.org/10.1086/721154
Brown bears are obese when they enter the den, and after 6 mo of hibernation and physical inactivity, bears show none of the adverse consequences of a sedentary lifestyle in humans, such as cardiovascular disease, type 2 diabetes, and kidney failure.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3001eafbdd9ff248532ec519e6e85480
https://pure.au.dk/portal/da/publications/differential-changes-in-circulating-steroid-hormones-in-hibernating-brown-bears(1b514921-66aa-4319-a7e2-e8f0ed89255b).html
https://pure.au.dk/portal/da/publications/differential-changes-in-circulating-steroid-hormones-in-hibernating-brown-bears(1b514921-66aa-4319-a7e2-e8f0ed89255b).html
Autor:
Luke D Boyle, Mark Nixon, Caroline Underhill, Lesley A Hill, John G Lewis, Geoffrey L Hammond, Oliver Wiedow, Peter A Henriksen, Roland H Stimson, Brian R Walker
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::333f6e84a5ce8ed51b8b141b980b6e8a
https://doi.org/10.1530/endoabs.81.p283
https://doi.org/10.1530/endoabs.81.p283
Autor:
Phillip Round, Anne Mette Frøbert, Ole Fröbert, Julia N C Toews, Geoffrey L. Hammond, Michael Toft Overgaard, Malene Brohus
Publikováno v:
FEBS Open Bio
FEBS Open Bio, Vol 12, Iss 2, Pp 362-378 (2022)
Frøbert, A M, Brohus, M, Toews, J N C, Round, P, Fröbert, O, Hammond, G L & Overgaard, M T 2022, ' Characterization and comparison of recombinant full-length ursine and human sex hormone-binding globulin ', FEBS open bio, vol. 12, no. 2, pp. 362-378 . https://doi.org/10.1002/2211-5463.13341
Frøbert, A M, Brohus, M, Toews, J N C, Round, P, Fröbert, O, Hammond, G L & Overgaard, M T 2022, ' Characterization and comparison of recombinant full-length ursine and human sex hormone-binding globulin ', FEBS Open Bio, vol. 12, no. 2, pp. 362-378 . https://doi.org/10.1002/2211-5463.13341
FEBS Open Bio, Vol 12, Iss 2, Pp 362-378 (2022)
Frøbert, A M, Brohus, M, Toews, J N C, Round, P, Fröbert, O, Hammond, G L & Overgaard, M T 2022, ' Characterization and comparison of recombinant full-length ursine and human sex hormone-binding globulin ', FEBS open bio, vol. 12, no. 2, pp. 362-378 . https://doi.org/10.1002/2211-5463.13341
Frøbert, A M, Brohus, M, Toews, J N C, Round, P, Fröbert, O, Hammond, G L & Overgaard, M T 2022, ' Characterization and comparison of recombinant full-length ursine and human sex hormone-binding globulin ', FEBS Open Bio, vol. 12, no. 2, pp. 362-378 . https://doi.org/10.1002/2211-5463.13341
Sex hormone‐binding globulin (SHBG) regulates the bioavailability of sex steroid hormones in the blood. Levels of SHBG increase markedly in brown bears (Ursus arctos) during hibernation, suggesting that a key regulatory role of this protein is to q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33043c4ed4680a215c8d4fa4780ddb9f
https://pubmed.ncbi.nlm.nih.gov/34855305
https://pubmed.ncbi.nlm.nih.gov/34855305
Autor:
Angela Delaney, Geoffrey L. Hammond, Fady Hannah-Shmouni, Chelsi Flippo, Marissa Lightbourne, Constantine A. Stratakis, Fabio R. Faucz, Victoria C. Andriessen
Publikováno v:
J Endocr Soc
Sex hormone–binding globulin (SHBG) in the blood is a major determinant of bioactivity for key sex steroids such as testosterone and estradiol. Low serum levels of SHBG have been associated with obesity, polycystic ovaries, and metabolic syndrome,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c22ca79f1a4b6c3a25f3d45a419b7db2
https://doi.org/10.1210/jendso/bvab125
https://doi.org/10.1210/jendso/bvab125