Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Geoffrey L. Chupp"'
iDESC: identifying differential expression in single-cell RNA sequencing data with multiple subjects
Autor:
Yunqing Liu, Jiayi Zhao, Taylor S. Adams, Ningya Wang, Jonas C. Schupp, Weimiao Wu, John E. McDonough, Geoffrey L. Chupp, Naftali Kaminski, Zuoheng Wang, Xiting Yan
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-20 (2023)
Abstract Background Single-cell RNA sequencing (scRNA-seq) technology has enabled assessment of transcriptome-wide changes at single-cell resolution. Due to the heterogeneity in environmental exposure and genetic background across subjects, subject e
Externí odkaz:
https://doaj.org/article/98bb000233a34cca8225fba23b3cf131
Autor:
Yunqing Liu, Jiayi Zhao, Taylor S. Adams, Ningya Wang, Jonas C. Schupp, Weimiao Wu, John E. McDonough, Geoffrey L. Chupp, Naftali Kaminski, Zuoheng Wang, Xiting Yan
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/3da99a1637a2445db9e02f0e0409547c
Autor:
Boyang Li, Yuxuan Wang, Zixiao Wang, Xinyue Li, Shannon Kay, Geoffrey L. Chupp, Hongyu Zhao, Jose L. Gomez
Publikováno v:
ERJ Open Research, Vol 9, Iss 4 (2023)
Rationale Asthma is a complex, heterogeneous disease strongly associated with type 2 inflammation, and blood eosinophil counts guide therapeutic interventions in moderate and severe asthma. Eosinophils are leukocytes involved in type 2 immune respons
Externí odkaz:
https://doaj.org/article/cf4dba32712a43009fff086a932b3f20
Autor:
William J. Calhoun, Geoffrey L. Chupp
Publikováno v:
Allergy, Asthma & Clinical Immunology, Vol 18, Iss 1, Pp 1-13 (2022)
Abstract Globally, a small proportion (5–12%) of asthma patients are estimated to have severe disease. However, severe asthma accounts for disproportionately high healthcare resource utilization. The Global Initiative for Asthma (GINA) management c
Externí odkaz:
https://doaj.org/article/4fbd6d8e6b9b4d6099d4142c57c8c64b
Autor:
Peter G. Gibson, Charlene M. Prazma, Geoffrey L. Chupp, Eric S. Bradford, Mark Forshag, Stephen A. Mallett, Steve W. Yancey, Steven G. Smith, Elisabeth H. Bel
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-12 (2021)
Abstract Background Comorbidities can complicate the management of severe asthma; therefore, the presence of comorbid conditions or traits often need to be considered when considering treatment options for patients with severe asthma. The aim of this
Externí odkaz:
https://doaj.org/article/4fe77ef5132740d89e33a7204d9137e6
Autor:
Ailu Chen, Maria P. Diaz-Soto, Miguel F. Sanmamed, Taylor Adams, Jonas C. Schupp, Amolika Gupta, Clemente Britto, Maor Sauler, Xiting Yan, Qing Liu, Gustavo Nino, Charles S. Dela Cruz, Geoffrey L. Chupp, Jose L. Gomez
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-15 (2021)
Abstract Background Asthma has been associated with impaired interferon response. Multiple cell types have been implicated in such response impairment and may be responsible for asthma immunopathology. However, existing models to study the immune res
Externí odkaz:
https://doaj.org/article/05c051abaec84697b39d9b4b3cb098cb
Autor:
Daniel Spakowicz, Shaoke Lou, Brian Barron, Jose L. Gomez, Tianxiao Li, Qing Liu, Nicole Grant, Xiting Yan, Rebecca Hoyd, George Weinstock, Geoffrey L. Chupp, Mark Gerstein
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-22 (2020)
Abstract Sputum induction is a non-invasive method to evaluate the airway environment, particularly for asthma. RNA sequencing (RNA-seq) of sputum samples can be challenging to interpret due to the complex and heterogeneous mixtures of human cells an
Externí odkaz:
https://doaj.org/article/2079b140836940ff8bfe600c13e3a387
Autor:
Aaron Hakim, Isabel S. Bazan, Mamadou L. Sanogo, Edward P. Manning, Jeffrey S. Pollak, Geoffrey L. Chupp
Publikováno v:
BMC Pulmonary Medicine, Vol 19, Iss 1, Pp 1-5 (2019)
Abstract Background Hyperimmunoglobulin E syndrome (HIES) is a rare primary immunodeficiency disorder defined by high serum immunoglobulin E titers that is associated with recurrent respiratory infections, formation of pneumoatoceles, recurrent skin
Externí odkaz:
https://doaj.org/article/de038037dbaf4451af1109b0829d53ef
A novel pathway-based distance score enhances assessment of disease heterogeneity in gene expression
Publikováno v:
BMC Bioinformatics, Vol 18, Iss 1, Pp 1-17 (2017)
Abstract Background Distance based unsupervised clustering of gene expression data is commonly used to identify heterogeneity in biologic samples. However, high noise levels in gene expression data and relatively high correlation between genes are of
Externí odkaz:
https://doaj.org/article/b6f9dd041c2446c9846bdec827b84894
Autor:
Klaus F. Rabe, Ian D. Pavord, William W. Busse, Geoffrey L. Chupp, Kenji Izuhara, Arman Altincatal, Rebecca Gall, Nami Pandit‐Abid, Yamo Deniz, Paul J. Rowe, Juby A. Jacob‐Nara, Amr Radwan
Publikováno v:
Allergy.