Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Geoffrey J. Barton"'
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Protein evolution is constrained by structure and function, creating patterns in residue conservation that are routinely exploited to predict structure and other features. Similar constraints should affect variation across individuals, but i
Externí odkaz:
https://doaj.org/article/0014ad2e277540efa747c99ce87d2b8f
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Fragment screening is used to identify binding sites and leads in drug discovery, but it is often unclear which binding sites are functionally important. Here, data from 37 experiments, and 1309 protein structures binding to 1601 ligands wer
Externí odkaz:
https://doaj.org/article/5023cc18ba294db4a0d28b3dcfc8e583
Publikováno v:
eLife, Vol 12 (2023)
Eukaryotic genes are interrupted by introns that are removed from transcribed RNAs by splicing. Patterns of splicing complexity differ between species, but it is unclear how these differences arise. We used inter-species association mapping with Sacc
Externí odkaz:
https://doaj.org/article/650763c85b0346eaa76881dd712d047c
Autor:
Carmen Escudero-Martinez, Max Coulter, Rodrigo Alegria Terrazas, Alexandre Foito, Rumana Kapadia, Laura Pietrangelo, Mauro Maver, Rajiv Sharma, Alessio Aprile, Jenny Morris, Pete E. Hedley, Andreas Maurer, Klaus Pillen, Gino Naclerio, Tanja Mimmo, Geoffrey J. Barton, Robbie Waugh, James Abbott, Davide Bulgarelli
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
A prerequisite to exploiting soil microbes for sustainable crop production is the identification of the plant genes shaping microbiota composition in the rhizosphere. Here, the authors report QTLs and the associated candidate genes underlying rhizosp
Externí odkaz:
https://doaj.org/article/1f7d8cc4cea14a8587b1e41e55eb2e96
Autor:
Jessen V. Bredeson, Jessica B. Lyons, Ibukun O. Oniyinde, Nneka R. Okereke, Olufisayo Kolade, Ikenna Nnabue, Christian O. Nwadili, Eva Hřibová, Matthew Parker, Jeremiah Nwogha, Shengqiang Shu, Joseph Carlson, Robert Kariba, Samuel Muthemba, Katarzyna Knop, Geoffrey J. Barton, Anna V. Sherwood, Antonio Lopez-Montes, Robert Asiedu, Ramni Jamnadass, Alice Muchugi, David Goodstein, Chiedozie N. Egesi, Jonathan Featherston, Asrat Asfaw, Gordon G. Simpson, Jaroslav Doležel, Prasad S. Hendre, Allen Van Deynze, Pullikanti Lava Kumar, Jude E. Obidiegwu, Ranjana Bhattacharjee, Daniel S. Rokhsar
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
While greater yam provides food and income security for millions of people around the world, there are limited genomic resources available. Here, the authors report a chromosome-scale assembly of the greater yam genome as well as quantitative trait l
Externí odkaz:
https://doaj.org/article/eb35eea4e0664d9da945b73fc5c47ae6
Autor:
Matthew T Parker, Beth K Soanes, Jelena Kusakina, Antoine Larrieu, Katarzyna Knop, Nisha Joy, Friedrich Breidenbach, Anna V Sherwood, Geoffrey J Barton, Sebastian M Fica, Brendan H Davies, Gordon G Simpson
Publikováno v:
eLife, Vol 11 (2022)
Alternative splicing of messenger RNAs is associated with the evolution of developmentally complex eukaryotes. Splicing is mediated by the spliceosome, and docking of the pre-mRNA 5’ splice site into the spliceosome active site depends upon pairing
Externí odkaz:
https://doaj.org/article/87994dd6570b469ebf3bf9d348881607
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-24 (2021)
Abstract Transcription of eukaryotic genomes involves complex alternative processing of RNAs. Sequencing of full-length RNAs using long reads reveals the true complexity of processing. However, the relatively high error rates of long-read sequencing
Externí odkaz:
https://doaj.org/article/006bdd1da0bc45ca800a01910114042d
Autor:
Stuart A MacGowan, Michael I Barton, Mikhail Kutuzov, Omer Dushek, P Anton van der Merwe, Geoffrey J Barton
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 3, p e1009922 (2022)
SARS-CoV-2 Spike (Spike) binds to human angiotensin-converting enzyme 2 (ACE2) and the strength of this interaction could influence parameters relating to virulence. To explore whether population variants in ACE2 influence Spike binding and hence inf
Externí odkaz:
https://doaj.org/article/dd7dfc2e89aa4c76b68bb960691ddf21
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 8, p e1009335 (2021)
Ankyrin protein repeats bind to a wide range of substrates and are one of the most common protein motifs in nature. Here, we collate a high-quality alignment of 7,407 ankyrin repeats and examine for the first time, the distribution of human populatio
Externí odkaz:
https://doaj.org/article/6338f9ce25324411a491b998c87e7f25
Autor:
Matthew T Parker, Katarzyna Knop, Vasiliki Zacharaki, Anna V Sherwood, Daniel Tomé, Xuhong Yu, Pascal GP Martin, Jim Beynon, Scott D Michaels, Geoffrey J Barton, Gordon G Simpson
Publikováno v:
eLife, Vol 10 (2021)
Genes involved in disease resistance are some of the fastest evolving and most diverse components of genomes. Large numbers of nucleotide-binding, leucine-rich repeat (NLR) genes are found in plant genomes and are required for disease resistance. How
Externí odkaz:
https://doaj.org/article/a93848093b644c9b91f021cb3118bfcf