Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Geoffrey J Laurent"'
Autor:
Maxim Pilyugin, Pascaline Descloux, Pierre-Alain André, Viktoria Laszlo, Balazs Dome, Balazs Hegedus, Sylvain Sardy, Samuel Janes, Andrea Bianco, Geoffrey J Laurent, Irmgard Irminger-Finger
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182356 (2017)
Currently the screening for lung cancer for risk groups is based on Computed Tomography (CT) or low dose CT (LDCT); however, the lung cancer death rate has not decreased significantly with people undergoing LDCT. We aimed to develop a simple reliable
Externí odkaz:
https://doaj.org/article/3c858d221384416286c1a87614ef638d
Autor:
Maria D I Manunta, Robin J McAnulty, Aristides D Tagalakis, Stephen E Bottoms, Frederick Campbell, Helen C Hailes, Alethea B Tabor, Geoffrey J Laurent, Christopher O'Callaghan, Stephen L Hart
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26768 (2011)
Gene therapy mediated by synthetic vectors may provide opportunities for new treatments for cystic fibrosis (CF) via aerosolisation. Vectors for CF must transfect the airway epithelium efficiently and not cause inflammation so they are suitable for r
Externí odkaz:
https://doaj.org/article/b4e704dda6444ec3ac8d0e904dd593d2
Autor:
Cecilia M. Prêle, Thomas Iosifidis, Robin J. McAnulty, David R. Pearce, Bahareh Badrian, Tylah Miles, Sarra E. Jamieson, Matthias Ernst, Philip J. Thompson, Geoffrey J. Laurent, Darryl A. Knight, Steven E. Mutsaers
Publikováno v:
Biomedicines, Vol 9, Iss 5, p 498 (2021)
The interleukin (IL)-6 family of cytokines and exaggerated signal transducer and activator of transcription (STAT)3 signaling is implicated in idiopathic pulmonary fibrosis (IPF) pathogenesis, but the mechanisms regulating STAT3 expression and functi
Externí odkaz:
https://doaj.org/article/f48fa198e8004c7484e59b7e0c37a1fd
Autor:
Cecilia M. Prêle, Tylah Miles, David R. Pearce, Robert J. O'Donoghue, Chris Grainge, Lucy Barrett, Kimberly Birnie, Andrew D. Lucas, Svetlana Baltic, Matthias Ernst, Catherine Rinaldi, Geoffrey J. Laurent, Darryl A. Knight, Mark Fear, Gerard Hoyne, Robin J. McAnulty, Steven E. Mutsaers
Publikováno v:
European Respiratory Journal. 60:2101469
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease associated with chronic inflammation and tissue remodelling leading to fibrosis, reduced pulmonary function, respiratory failure and death. Bleomycin (Blm)-induced lung fibrosis in m
Autor:
Geoffrey J. Laurent, Philip J. Thompson, David R. Pearce, Sarra E. Jamieson, Matthias Ernst, Tylah Miles, Cecilia M Prêle, Robin J. McAnulty, Darryl A. Knight, Bahareh Badrian, Steven E. Mutsaers, Thomas Iosifidis
Publikováno v:
Biomedicines, Vol 9, Iss 498, p 498 (2021)
Biomedicines
Volume 9
Issue 5
Biomedicines
Volume 9
Issue 5
The interleukin (IL)-6 family of cytokines and exaggerated signal transducer and activator of transcription (STAT)3 signaling is implicated in idiopathic pulmonary fibrosis (IPF) pathogenesis, but the mechanisms regulating STAT3 expression and functi
Autor:
Anne S. Kramer, Geoffrey J. Laurent, George C.T. Yeoh, Lingjun Mou, Caryn L. Elsegood, Bruce Latham, Luke A. Diepeveen, Laura Ochoa-Callejero
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Scientific Reports
Hepatic progenitor cells (HPCs) play an important regenerative role in acute and chronic liver pathologies. Liver disease research often necessitates the grading of disease severity, and pathologists’ reports are the current gold-standard for asses
Autor:
Pearce G. Wilcox, Joel M. Guthridge, Oliver Eickelberg, Mary E. Strek, Michael P. Keane, Yasunari Miyazaki, Doris Rassl, Osamu Narumoto, Moisés Selman, Jonathan A. Kropski, Maryl Kreider, Seamus C. Donnelly, Joao A. de Andrade, Geoffrey J. Laurent, Claudia Ravaglia, Michelle E. Armstong, Peter Saunders, Edwin K. Silverman, Yuben Moodley, Sydney B. Montesi, Tsukasa Okamoto, John S. Sundy, Tasha E. Fingerlin, Julie Powers, Jonathan Cardwell, Masaki Hirose, John Sembrat, Joyce S. Lee, Ho Cheol Kim, Yoshikazu Inoue, Karin A. Pacheco, David A. Schwartz, Tarik Walker, Ivana V. Yang, Camille M. Moore, Roberto Carbone, Martina Vasakova, Steven D. Nathan, Vivi Danchel, Michael Henry, Thomas G. O'Riordan, Helen Parfrey, Annie Pardo, Merte Lemma WoldeHanna, Nesrin Mogulkoc, Francesco Bonella, Philip L. Molyneaux, Alvaro Aranda, Martina Sterclova, Yingze Zhang, Ian Glaspole, Toby M. Maher, Barry S. Shea, Tejaswini Kulkarni, Peter Doran, Maria Molina-Molina, Namrata Patel, Haruhiko Furusawa, Dong Soon Kim, Kenneth B. Beckman, Svetlana Baltic, Feng Li, Drew C. Venuto, Harold R. Collard, Avram D Walts, Venerino Poletti, Shwu Fan Ma, Maho Suzukawa, Tracy Luckhardt, Nikhil Hirani, Wonjun Ji, Bruno Crestani, Kevin K. Brown, R. Gisli Jenkins, Caroline Kannengiesser, Christopher J. Ryerson, Aoife McElroy, Pamela Russell, Marvin I. Schwarz, Jin Woo Song, Ana Montes Worboys, Rachel Z. Blumhagen, Gauri Saini, Gunnar Gudmundsson, James D. Crapo, Paul J. Wolters, Sara Tomassetti, Christine A Fiddler, Lisa A. Maier, Carol Bair, Nurdan Kokturk, James E. Loyd, Rebecca Braybrooke, Shinobu Akagawa, Raphael Borie, Mauricio Rojas, Jürgen Behr, Tamera J. Corte, Michael H. Cho, Joy D. Cogan, Mark P. Steele, Susan K. Mathai, Francesco Puppo, Toru Arai, Kevin F. Gibson, Makenna Bishop, Isis E. Fernandez, Mary K. Porteous, Imre Noth, Jeffrey J. Swigris, Anna J. Podolanczuk, Brian Vestal, Cecilia M. Prêle, Ken Ohta, David J. Lederer, Deborah A. Nickerson, Elisabeth Bendstrup, Helgi J Isaksson, Cheryl Markin, Judith A. James, Carlos Machahua, Daniel J. Kass, Azin S. Poon
Publikováno v:
Moore, C, Blumhagent, R Z, Yang, I, Walts, A, Powers, J, Walker, T, Bishop, M, Russell, P, Vestal, B, Cardwell, J, Markin, C R, Mathai, S K, Schwarz, M, Steele, M P, Lee, J, Brown, K K, Loyd, J E, Crapo, J D, Silverman, E K, Cho, M H, James, J A, Guthridge, J M, Cogan, J D, Kropski, J A, Swigris, J J, Bair, C, Kim, D S, Ji, W, Kim, H, Song, J W, Maier, L A, Pacheco, K A, Hirani, N, Poon, A S, Li, F, Jenkins, R G, Braybrooke, R, Saini, G, Maher, T M, Molyneaux, P L, Saunders, P, Zhang, Y, Gibson, K F, Kass, D J, Rojas, M, Sembrat, J, Wolters, P J, Collard, H R, Sundy, J S, O'Riordan, T, Strek, M E, Noth, I, Ma, S-F, Porteous, M K, Kreider, M E, Patel, N B, Inoue, Y, Hirose, M, Arai, T, Akagawa, S, Eickelberg, O, Fernandez, I E, Behr, J, Mogulkoc, N, Corte, T J, Glaspole, I, Tomassetti, S, Ravaglia, C, Poletti, V, Crestani, B, Borie, R, Kannengiesser, C, Parfrey, H, Fiddler, C, Rassl, D, Molina-Molina, M, Machahua, C, Worboys, A M, Gudmundsson, G, Isaksson, H J, Lederer, D J, Podolanczuk, A J, Montesi, S B, Bendstrup, E, Danchel, V, Selman, M, Pardo, A, Henry, M T, Keane, M P, Doran, P, Vasakova, M, Sterclova, M, Ryerson, C J, Wilcox, P G, Okamoto, T, Furusawa, H, Miyazaki, Y, Laurent, G, Baltic, S, Prele, C, Moodley, Y, Shea, B S, Ohta, K, Suzukawa, M, Narumoto, O, Nathan, S D, Venuto, D C, Woldehanna, M L, Kokturk, N, de Andrade, J A, Luckhardt, T, Kulkarni, T, Bonella, F, Donnelly, S C, McElroy, A, Armstong, M E, Aranda, A, Carbone, R G, Puppo, F, Beckman, K B, Nickerson, D A, Fingerlin, T E & Schwartz, D A 2019, ' Resequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis ', American Journal of Respiratory and Critical Care Medicine, vol. 200, no. 2, pp. 199-208 . https://doi.org/10.1164/rccm.201810-1891OC
American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine
EgeUn###
Rationale: Several common and rare genetic variants have been associated with idiopathic pulmonary fibrosis, a progressive fibrotic condition that is localized to the lung. Objectives: To develop an integrated understanding of the rare
Rationale: Several common and rare genetic variants have been associated with idiopathic pulmonary fibrosis, a progressive fibrotic condition that is localized to the lung. Objectives: To develop an integrated understanding of the rare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf8f84bf2c327db6ba54e2e2fd98f38
https://avesis.gazi.edu.tr/publication/details/f613fd2f-e91e-43a2-b4b6-51badcef53d8/oai
https://avesis.gazi.edu.tr/publication/details/f613fd2f-e91e-43a2-b4b6-51badcef53d8/oai
Autor:
Michael Wood, Bruce W. S. Robinson, Keith S. Abayasiriwardana, Kimberly A Birnie, Geoffrey J. Laurent, Robin J. McAnulty, Steven E. Mutsaers, Cecilia M. Prêle
Publikováno v:
Biochemical and biophysical research communications. 510(2)
Malignant mesothelioma is an aggressive fibrous tumor, predominantly of the pleura, with a very poor prognosis. Cell-matrix interactions are recognized important determinants of tumor growth and invasiveness but the role of the extracellular matrix i
Autor:
Geoffrey J. Laurent, Joanne Porte, Alison E. John, Sharon M. Wahl, Gisli Jenkins, Amanda L. Tatler, Anthony Habgood, Simon R. Johnson
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology
Idiopathic Pulmonary Fibrosis (IPF) is a progressive, fatal disease with limited treatment options. Protease mediated transforming growth factor-β (TGF-β) activation has been proposed as a pathogenic mechanism of lung fibrosis. Protease activity in