Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Geoffrey J, Faulkner"'
Autor:
Patricia Gerdes, Sue Mei Lim, Adam D. Ewing, Michael R. Larcombe, Dorothy Chan, Francisco J. Sanchez-Luque, Lucinda Walker, Alexander L. Carleton, Cini James, Anja S. Knaupp, Patricia E. Carreira, Christian M. Nefzger, Ryan Lister, Sandra R. Richardson, Jose M. Polo, Geoffrey J. Faulkner
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Retrotransposons are mobile genetic elements normally repressed by DNA methylation in differentiated cells. Here, the authors show that DNA hypomethylation in mouse induced pluripotent stem cells allows retrotransposons to jump, but this can be block
Externí odkaz:
https://doaj.org/article/b8c17138d7be4d378e40d7894f019bb7
Autor:
Robin-Lee Troskie, Yohaann Jafrani, Tim R. Mercer, Adam D. Ewing, Geoffrey J. Faulkner, Seth W. Cheetham
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-15 (2021)
Abstract Pseudogenes are gene copies presumed to mainly be functionless relics of evolution due to acquired deleterious mutations or transcriptional silencing. Using deep full-length PacBio cDNA sequencing of normal human tissues and cancer cell line
Externí odkaz:
https://doaj.org/article/3702d87f702146c4889888e2897d0e4b
Autor:
Natasha Jansz, Geoffrey J. Faulkner
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-22 (2021)
Abstract Endogenous retroviruses (ERVs) are emerging as promising therapeutic targets in cancer. As remnants of ancient retroviral infections, ERV-derived regulatory elements coordinate expression from gene networks, including those underpinning embr
Externí odkaz:
https://doaj.org/article/55fe74333a144d3583d23d82a2124c94
Autor:
Geoffrey J. Faulkner
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-3 (2021)
Externí odkaz:
https://doaj.org/article/ba2fe61d1da2475ab7b49048b035e2d6
Autor:
Katherine D. Drummond, Michelle L. Waring, Geoffrey J. Faulkner, Marnie E. Blewitt, Christina J. Perry, Jee Hyun Kim
Publikováno v:
Neurobiology of Stress, Vol 15, Iss , Pp 100367- (2021)
Impaired extinction of conditioned fear is associated with anxiety disorders. Common lifestyle factors, like isolation stress and exercise, may alter the ability to extinguish fear. However, the effect of and interplay between these factors on adoles
Externí odkaz:
https://doaj.org/article/8a0d213a25ed4c6f828bb4034f6d07d6
Autor:
Lucia C. Strader, Max V. Staller, Anne E. Willis, Geoffrey J. Faulkner, Jean D. Beggs, Thomas R. Cech
Publikováno v:
Molecular Cell. 83:320-323
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1219fe3573fd14f219c3c8c94554b1b
https://doi.org/10.1016/j.molcel.2023.01.002
https://doi.org/10.1016/j.molcel.2023.01.002
Autor:
Geoffrey J. Faulkner, Victor Billon
Publikováno v:
Mobile DNA, Vol 9, Iss 1, Pp 1-18 (2018)
Abstract Retrotransposons are transposable elements (TEs) capable of “jumping” in germ, embryonic and tumor cells and, as is now clearly established, in the neuronal lineage. Mosaic TE insertions form part of a broader landscape of somatic genome
Externí odkaz:
https://doaj.org/article/bee67c93b5c2498396703f4aa4970604
Autor:
Thu H.M. Nguyen, Patricia E. Carreira, Francisco J. Sanchez-Luque, Stephanie N. Schauer, Allister C. Fagg, Sandra R. Richardson, Claire M. Davies, J. Samuel Jesuadian, Marie-Jeanne H.C. Kempen, Robin-Lee Troskie, Cini James, Elizabeth A. Beaven, Tristan P. Wallis, Jermaine I.G. Coward, Naven P. Chetty, Alexander J. Crandon, Deon J. Venter, Jane E. Armes, Lewis C. Perrin, John D. Hooper, Adam D. Ewing, Kyle R. Upton, Geoffrey J. Faulkner
Publikováno v:
Cell Reports, Vol 23, Iss 13, Pp 3730-3740 (2018)
Summary: LINE-1 (L1) retrotransposons are a source of insertional mutagenesis in tumor cells. However, the clinical significance of L1 mobilization during tumorigenesis remains unclear. Here, we applied retrotransposon capture sequencing (RC-seq) to
Externí odkaz:
https://doaj.org/article/02b2c6ba831b4bec8988f6149861dbe1
Autor:
John M. Abrams, Irina R. Arkhipova, Marlene Belfort, Jef D. Boeke, M. Joan Curcio, Geoffrey J. Faulkner, John L. Goodier, Ruth Lehmann, Henry L. Levin
Publikováno v:
Mobile DNA, Vol 9, Iss 1, Pp 1-10 (2018)
Abstract The Mobile Genetic Elements and Genome Plasticity conference was hosted by Keystone Symposia in Santa Fe, NM USA, February 11–15, 2018. The organizers were Marlene Belfort, Evan Eichler, Henry Levin and Lynne Maquat. The goal of this confe
Externí odkaz:
https://doaj.org/article/23d9b2dfae184f648f579f672b3605c4
Autor:
Bassier Zadran, Praveen Dhondurao Sudhindar, Daniel Wainwright, Yvonne Bury, Saimir Luli, Rachel Howarth, Misti Vanette McCain, Robyn Watson, Hannah Huet, Fanni Palinkas, Rolando Berlinguer-Palmini, John Casement, Derek A. Mann, Fiona Oakley, John Lunec, Helen Reeves, Geoffrey J. Faulkner, Ruchi Shukla
Publikováno v:
British Journal of Cancer. 128:1236-1248
Background Molecular characterisation of hepatocellular carcinoma (HCC) is central to the development of novel therapeutic strategies for the disease. We have previously demonstrated mutagenic consequences of Long-Interspersed Nuclear Element-1 (LINE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c90dab2a8ed53492f5015164c5a984f3
https://doi.org/10.1038/s41416-023-02154-9
https://doi.org/10.1038/s41416-023-02154-9