Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Geoffrey Harold Baker"'
Autor:
Geoffrey Harold Baker, Roderick John Dorgan, S. A. Readshaw, B. R. Manger, Simon Edward Blanchflower, Jeremy R. Everett, Christopher Reading, Peter Robin Shelley
Publikováno v:
The Journal of Antibiotics. 49:272-280
Ten novel alpha and beta class milbemycins have been isolated and characterized from the Streptomyces sp. E225, which has previously been shown to produce four related milbemycins. Some of the metabolites contain new structural features including, VM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::646e7b9d95ae75bc9e1b06e8944d2cc6
https://doi.org/10.7164/antibiotics.49.272
https://doi.org/10.7164/antibiotics.49.272
Autor:
Roderick John Dorgan, Geoffrey Harold Baker, Nigel Hussain, Graham S. Macaulay, David O. Morgan
Publikováno v:
Tetrahedron Letters. 35:2381-2384
The lactone intermediates (3), (4) and (5) are converted via lithium acetylide chemistry to a range of novel C24 and C25-substituted milbemycins. The methdology has been extended to afford milbemycins containing 6,5-spiroacetal units.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::471b537f2c3be15b3ed22245e6c0c47c
https://doi.org/10.1016/0040-4039(94)85225-1
https://doi.org/10.1016/0040-4039(94)85225-1
Autor:
Roderick John Dorgan, David O. Morgan, Graham S. Macaulay, Geoffrey Harold Baker, Nigel Hussain
Publikováno v:
Tetrahedron Letters. 35:2377-2380
Beckmann fragmentation of 22-oximino milbemycins resulted in the cleavage of the C21–C22 bond to produce a key lactone intermediate which can be used to synthesise new spiroacetals. Cleavage of the C21–O25 bond and recyclisation to produce a fury
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e42e16384135a7381453199d9d512fa9
https://doi.org/10.1016/0040-4039(94)85224-3
https://doi.org/10.1016/0040-4039(94)85224-3
Autor:
Geoffrey Harold Baker, Nigel Hussain, Joseph F. Hudner, David O. Morgan, Roderick John Dorgan
Publikováno v:
Tetrahedron Letters. 35:2385-2388
The lactone intermediates (2) and (3) are converted by lithium acetylide chemistry followed by mercury catalysed hydration to novel semi-synthetic 23-oxo C24 and C25 substituted milbemycins (7).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee21ef71bb50827e8a75823a52787548
https://doi.org/10.1016/0040-4039(94)85226-x
https://doi.org/10.1016/0040-4039(94)85226-x
Autor:
Roderick John Dorgan, Graham S. Macaulay, David O. Morgan, Geoffrey Harold Baker, Nigel Hussain
Publikováno v:
ChemInform. 25
Beckmann fragmentation of 22-oximino milbemycins resulted in the cleavage of the C21–C22 bond to produce a key lactone intermediate which can be used to synthesise new spiroacetals. Cleavage of the C21–O25 bond and recyclisation to produce a fury
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bea291c4085142bd00e5a29e562ef62
https://doi.org/10.1002/chin.199432242
https://doi.org/10.1002/chin.199432242
Autor:
Roderick John Dorgan, Nigel Hussain, Joseph F. Hudner, David O. Morgan, Geoffrey Harold Baker
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::326bfe9ebd6a1664edabe4d8eba1e3b0
https://doi.org/10.1002/chin.199432244
https://doi.org/10.1002/chin.199432244
Autor:
S. A. Readshaw, Jeremy R. Everett, Christopher Reading, Roderick John Dorgan, Simon Edward Blanchflower, Geoffrey Harold Baker, Peter Robin Shelley, B. R. Manger
Publikováno v:
ChemInform. 27
Ten novel alpha and beta class milbemycins have been isolated and characterized from the Streptomyces sp. E225, which has previously been shown to produce four related milbemycins. Some of the metabolites contain new structural features including, VM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::769c79d111b8db22bb2bc5e5f721a9d8
https://doi.org/10.1002/chin.199635236
https://doi.org/10.1002/chin.199635236
Publikováno v:
ChemInform. 21
The 1H and 13C NMR spectra of bafilomycin A1(1), 21-O-trimethylsilylbafilomycin A1(2) and 7-O-acetyl-21-O-t-butyldimethylsilylbafilomycin A1(3) have been unambiguously solved in a variety of solvents by 1D and 2D NMR techniques. Partial deuteriation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d06acaa33126a5714f87742bc91b32b1
https://doi.org/10.1002/chin.199036313
https://doi.org/10.1002/chin.199036313
Publikováno v:
The Journal of antibiotics. 43(9)
A novel series of milbemycin antibiotics were isolated from the fermentation broth of a Streptomyces species designated E225. The structures of the four main metabolites VM 44857 (1), VM 44864 (2), VM 44865 (3) and VM 44866 (4) were determined by NMR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b765d6cad132f3290cf6b244636c66d
https://pubmed.ncbi.nlm.nih.gov/2211369
https://pubmed.ncbi.nlm.nih.gov/2211369
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 2. :717
The 1H and 13C NMR spectra of bafilomycin A1(1), 21-O-trimethylsilylbafilomycin A1(2) and 7-O-acetyl-21-O-t-butyldimethylsilylbafilomycin A1(3) have been unambiguously solved in a variety of solvents by 1D and 2D NMR techniques. Partial deuteriation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42d6818bc2e41cea1f92d304e264364b
https://doi.org/10.1039/p29900000717
https://doi.org/10.1039/p29900000717