Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Geoffrey De Couto"'
Autor:
Ryo Hotta, Ahmed Rahman, Sukhada Bhave, Rhian Stavely, Weikang Pan, Shriya Srinivasan, Geoffrey de Couto, Luis Rodriguez-Borlado, Richard Myers, Alan J. Burns, Allan M. Goldstein
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Background Enteric neuropathies, which result from abnormalities of the enteric nervous system, are associated with significant morbidity and high health-care costs, but current treatments are unsatisfactory. Cell-based therapy offers an inn
Externí odkaz:
https://doaj.org/article/3507b616264b4da0a5ab836cf0ab4178
Autor:
Ryo Hotta, Weikang Pan, Sukhada Bhave, Nandor Nagy, Rhian Stavely, Takahiro Ohkura, Kumar Krishnan, Geoffrey de Couto, Richard Myers, Luis Rodriguez-Borlado, Alan J. Burns, Allan M. Goldstein
Publikováno v:
Cell Transplantation, Vol 32 (2023)
The enteric nervous system (ENS) is an extensive network of neurons and glia within the wall of the gastrointestinal (GI) tract that regulates many essential GI functions. Consequently, disorders of the ENS due to developmental defects, inflammation,
Externí odkaz:
https://doaj.org/article/2be94383c769473181d73fdc2d28dfb1
Autor:
Jae Hyung Cho, Peter J. Kilfoil, Rui Zhang, Ryan E. Solymani, Catherine Bresee, Elliot M. Kang, Kristin Luther, Russell G. Rogers, Geoffrey de Couto, Joshua I. Goldhaber, Eduardo Marbán, Eugenio Cingolani
Publikováno v:
JCI Insight, Vol 8, Iss 13 (2023)
Externí odkaz:
https://doaj.org/article/b12ebb0e17ea400782dc33e212734fab
Autor:
Feng Huang, Na Na, Takeshi Ijichi, Xiaokang Wu, Kazutaka Miyamoto, Alessandra Ciullo, My Tran, Liang Li, Ahmed Ibrahim, Eduardo Marbán, Geoffrey de Couto
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 24, Iss , Pp 951-960 (2021)
Cardiosphere-derived cell exosomes (CDCexo) and YF1, a CDCexo-derived non-coding RNA, elicit therapeutic bioactivity in models of myocardial infarction and hypertensive hypertrophy. Here we tested the hypothesis that YF1, a 56-nucleotide Y RNA fragme
Externí odkaz:
https://doaj.org/article/64b0cb96b24f405fbd1cfd3c70f46cd6
Autor:
Ann-Sophie Walravens, Sasha Smolgovsky, Liang Li, Lauren Kelly, Travis Antes, Kiel Peck, Tanner Quon, Ahmed Ibrahim, Eduardo Marbán, Benjamin Berman, Linda Marbán, Luis R.-Borlado, Geoffrey de Couto
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Cell therapy limits ischemic injury following myocardial infarction (MI) by preventing cell death, modulating the immune response, and promoting tissue regeneration. The therapeutic efficacy of cardiosphere-derived cells (CDCs) and mesenchym
Externí odkaz:
https://doaj.org/article/7a83485ee04f42dbafb63c973bb42fd4
Autor:
Geoffrey de Couto
Publikováno v:
Experimental and Molecular Medicine, Vol 51, Iss 12, Pp 1-10 (2019)
Heart disease: Rebooting immune cells to repair the heart The human heart may be coaxed toward regeneration by modifying the activity of specialized immune cells known as macrophages. Insight from the regenerating hearts of zebrafish, newt, and neona
Externí odkaz:
https://doaj.org/article/b7610bfdaae246fc9bf1b43f0371a626
Autor:
Linda Cambier, Geoffrey de Couto, Ahmed Ibrahim, Antonio K Echavez, Jackelyn Valle, Weixin Liu, Michelle Kreke, Rachel R Smith, Linda Marbán, Eduardo Marbán
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 3, Pp 337-352 (2017)
Abstract Cardiosphere‐derived cells (CDCs) reduce myocardial infarct size via secreted extracellular vesicles (CDC‐EVs), including exosomes, which alter macrophage polarization. We questioned whether short non‐coding RNA species of unknown func
Externí odkaz:
https://doaj.org/article/1565724645d04bdea2518be0a581c8fb
Autor:
Ryan C. Middleton, Russell G. Rogers, Geoffrey De Couto, Eleni Tseliou, Kristin Luther, Ronald Holewinski, Daniel Soetkamp, Jennifer E. Van Eyk, Travis J. Antes, Eduardo Marbán
Publikováno v:
Journal of Extracellular Vesicles, Vol 7, Iss 1 (2018)
Newts can regenerate amputated limbs and cardiac tissue, unlike mammals which lack broad regenerative capacity. Several signaling pathways involved in cell proliferation, differentiation and survival during newt tissue regeneration have been elucidat
Externí odkaz:
https://doaj.org/article/f6a012b05ee847b498316ab3b6138261
Autor:
Romain Gallet, MD, Geoffrey de Couto, PhD, Eli Simsolo, BS, Jackelyn Valle, BS, Baiming Sun, MD, Weixin Liu, MS, Eleni Tseliou, MD, Michael R. Zile, MD, Eduardo Marbán, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 1, Iss 1, Pp 14-28 (2016)
The pathogenesis of heart failure with a preserved ejection fraction (HFpEF) is unclear. Myocardial fibrosis, inflammation, and cardiac hypertrophy have been suggested to contribute to the pathogenesis of HFpEF. Cardiosphere-derived cells (CDCs) are
Externí odkaz:
https://doaj.org/article/1b067f92a4f448049f4e8555db382c4e
Autor:
Hideaki Kanazawa, Eleni Tseliou, James F. Dawkins, Geoffrey De Couto, Romain Gallet, Konstantinos Malliaras, Kristine Yee, Michelle Kreke, Ileana Valle, Rachel R. Smith, Ryan C. Middleton, Chak‐Sum Ho, Rohan Dharmakumar, Debiao Li, Raj R. Makkar, Keiichi Fukuda, Linda Marbán, Eduardo Marbán
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 2 (2016)
BackgroundInfusion of allogeneic cardiosphere‐derived cells (allo‐CDCs) postreperfusion elicits cardioprotective cellular postconditioning in pigs with acute myocardial infarction. However, the long‐term effects of allo‐CDCs have not been ass
Externí odkaz:
https://doaj.org/article/66e5dab1634247818be04a3dfdc81abe