Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Geoffrey Cooper"'
1
Identifying Molecules as Biosignatures with Assembly Theory and Mass Spectrometry
Autor: stuart Marshall, Cole Mathis, Emma Carrick, Graham Keenan, Geoffrey Cooper, Heather Graham, Jessica Bame, Matthew Craven, Nicola Bell, Piotr S. Gromski, Marcel Swart, Douglas G. Moore, Sara Walker, Leroy Cronin
The search for evidence of life elsewhere in the universe is hard because it is not obvious what signatures are unique to life. Here we postulate that complex molecules found in high abundance are universal biosignatures as they cannot form by chance
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d0c978b8bfffd73eb796d64b7a0801b
https://doi.org/10.26434/chemrxiv.13227881
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2
Integrated Synthesis of Nucleotide and Nucleosides Directed by Amino Acids
Autor: Irene Suárez-Marina, Rebecca Turk-MacLeod, Yousef Abul-Haija, Piotr S. Gromski, Geoffrey Cooper, Leroy Cronin
Research on the origin of nucleic acids and proteins has been approached by either multi-step synthesis or simple one-pot reactions, but exploration of their prebiotic chemistry is normally done separately. However, if nucleotides and amino acids co-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba1774772464c71af7dbea56b9d5babd
https://doi.org/10.26434/chemrxiv.6972785.v1
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3
Synthesis of Novel Cationic Lipids: Effect of Structural Modification on the Efficiency of Gene Transfer
Autor: Robert Geoffrey Cooper, Caroline J. Springer, Dan Niculescu-Duvaz, James Anthony Heyes
Publikováno v: Journal of Medicinal Chemistry. 45:99-114
A series of novel cationic lipids was designed and synthesized in an effort to understand the importance of the various structural features with respect to transfection efficiency. Particular attention has been paid to the hydrophobic domain and the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5671dfeafbe3cb323185998c2a85ee
https://doi.org/10.1021/jm010918g
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4
The Ras/Rac1/Cdc42/SEK/JNK/c-Jun Cascade Is a Key Pathway by Which Agonists Stimulate DNA Synthesis in Primary Cultures of Rat Hepatocytes
Autor: Michael J. Birrer, Paul Dent, Luciano Pirola, Geoffrey Cooper, Joseph N. Contessa, Matthias P. Wymann, Stefano Brenz-Verca, Kelly L. Auer, Sandro Rusconi, Roger J. Davis, Arie Abo
Publikováno v: Molecular Biology of the Cell. 9:561-573
The ability of signaling via the JNK (c-Jun NH2-terminal kinase)/stress-activated protein kinase cascade to stimulate or inhibit DNA synthesis in primary cultures of adult rat hepatocytes was examined. Treatment of hepatocytes with media containing h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::450cba9973f4217b371877f2bf3e427e
https://doi.org/10.1091/mbc.9.3.561
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6
Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation
Autor: Richard Marais, Christopher J. Marshall, Clive S. Mason, Robert Geoffrey Cooper, Caroline J. Springer, Giulio Superti-Furga
Publikováno v: The EMBO journal. 18(8)
The Raf family of serine/threonine protein kinases couple growth factor receptor stimulation to mitogen activated protein kinase activation, but their own regulation is poorly understood. Using phospho-specific antisera, we show that activated Raf-1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc2ab186cef3b4f98d66746fe0a2a34
https://pubmed.ncbi.nlm.nih.gov/10205168
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7
Photoaffinity labelling of a cytokinin-binding integral membrane protein in plant mitochondria
Autor: Gayatri Shah, Chris Brinegar, Geoffrey Cooper
Publikováno v: Plant Hormone Signal Perception and Transduction ISBN: 9789401065467
Two target polypeptides were detected by photoaffinity labelling of purified mung bean mitochondria using tritiated 2-azido-N6-benzylaminopurine. SDS-PAGE and fluorography of total mitochondrial proteins after the photoaffinity reaction showed a labe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6085a3bbf135f15fadfefd78ced57c25
https://doi.org/10.1007/978-94-009-0131-5_12
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9
Method for synthesis of 2-azido-N(6)-m-tritiobenzylaminopurine, a photoaffinity label for cytokinin-binding proteins in plants
Autor: J. Eugene Fox, Miroslav Kaminek, James Bourell, Geoffrey Cooper
Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 25:957-962
A method for tritiation of 2-azido-N(6)-benzyladenine (AZBA), a photoaffinity analog of the plant hormone N(6)-benzyladenine (BA), was developed. The synthetic sequence involves condensation of 2,6-dichloropurine with m-iodobenzylamine to yield 2-chl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3ada6bd82c1c0b4c7fa27c899f76f13
https://doi.org/10.1002/jlcr.2580250906
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10
Photoaffinity analog of herbicide inhibiting cellulose biosynthesis: Synthesis of [3H]-2,6-dichlorophenylazide
Autor: Deborah P. Delmer, Carmen I. Nitsche, Geoffrey Cooper
Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 24:759-761
The compound 2,6-dichlorobenzonitrile (dichlobenil, DCB) is known to be a reversible inhibitor of in vivo cellulose biosynthesis in higher plants and algae. We now report the synthesis of 2,6-dichlorophenylazide (DCPA) with a non-exchangeable tritium
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b0ee1be70cfa30cbab35f101aff4b80
https://doi.org/10.1002/jlcr.2580240705
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