Zobrazeno 1 - 10
of 349
pro vyhledávání: '"Geoffrey C, Farrell"'
Autor:
Christian L. Horn, Amilcar L. Morales., Christopher Savard, Geoffrey C Farrell, George N. Ioannou
Publikováno v:
Hepatology Communications, Vol 6, Iss 1, Pp 12-35 (2022)
The rising prevalence of nonalcoholic fatty liver disease (NAFLD) and NAFLD‐related cirrhosis in the United States and globally highlights the need to better understand the mechanisms causing progression of hepatic steatosis to fibrosing steatohepa
Externí odkaz:
https://doaj.org/article/4f097a96f8524768bc96ff42f332dc82
The sharp rise in cases of Non-alcoholic fatty liver disease is fast becoming one of the major concerns for hepatologists worldwide. This comprehensive clinical guide explains how to diagnose NAFLD and manage patients according to the best standards
Autor:
George N. Ioannou, Charles S. Landis, Ga‐Young Jin, W. Geoffrey Haigh, Geoffrey C. Farrell, Rahul Kuver, Sum P. Lee, Christopher Savard
Publikováno v:
Hepatology Communications, Vol 3, Iss 6, Pp 776-791 (2019)
It is unclear what drives the development of fibrosing nonalcoholic steatohepatitis (NASH). We aimed to determine whether cholesterol crystallization within hepatocyte lipid droplets (LDs) distinguishes patients with fibrosing NASH from patients with
Externí odkaz:
https://doaj.org/article/8c4438f8f6c6437b998d19525840e1a2
Autor:
George N. Ioannou, Savitha Subramanian, Alan Chait, W. Geoffrey Haigh, Matthew M. Yeh, Geoffrey C. Farrell, Sum P. Lee, Christopher Savard
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 6, Pp 1067-1079 (2017)
We recently reported that cholesterol crystals form in hepatocyte lipid droplets (LDs) in human and experimental nonalcoholic steatohepatitis. Herein, we assigned WT C57BL/6J mice to a high-fat (15%) diet for 6 months, supplemented with 0%, 0.25%, 0.
Externí odkaz:
https://doaj.org/article/64140dc3cc9a4d47bcb07f51a58c9e39
Autor:
Geoffrey C. Farrell, Amilcar Morales, George N. Ioannou, Christopher E. Savard, Christian L. Horn
Publikováno v:
Hepatology Communications, Vol 6, Iss 1, Pp 12-35 (2022)
Hepatology Communications
Hepatology Communications
The rising prevalence of nonalcoholic fatty liver disease (NAFLD) and NAFLD‐related cirrhosis in the United States and globally highlights the need to better understand the mechanisms causing progression of hepatic steatosis to fibrosing steatohepa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::686feba9ac6a8bba91002d73e5303d5a
https://doaj.org/article/4f097a96f8524768bc96ff42f332dc82
https://doaj.org/article/4f097a96f8524768bc96ff42f332dc82
Autor:
George N. Ioannou, Derrick M. Van Rooyen, Christopher Savard, W. Geoffrey Haigh, Matthew M. Yeh, Narci C. Teoh, Geoffrey C. Farrell
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 2, Pp 277-285 (2015)
Cholesterol crystals form within hepatocyte lipid droplets in human and experimental nonalcoholic steatohepatitis (NASH) and are the focus of crown-like structures (CLSs) of activated Kupffer cells (KCs). Obese, diabetic Alms1 mutant (foz/foz) mice w
Externí odkaz:
https://doaj.org/article/228bae4d70a1443cb3f82ef6233eeb08
Autor:
W. Geoffrey Haigh, Sharon Pok, Vanessa Barn, Geoffrey C. Farrell, Narci C. Teoh, Arfianti Arfianti, Matthew M. Yeh, George N. Ioannou
Publikováno v:
Journal of Hepatology. 73:140-148
Obesity and type 2 diabetes increase hepatocellular carcinoma (HCC) incidence in humans and accelerate diethylnitrosamine (DEN)-induced hepatocarcinogenesis in mice. We investigated whether exercise reduces HCC development in obese/diabetic Alms1 mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2363ce76621d5314ee19f5cc834cca4
https://doi.org/10.1016/j.jhep.2020.02.006
https://doi.org/10.1016/j.jhep.2020.02.006
Autor:
Geoffrey C. Farrell, W. d’Avigdor, Susan V. McLennan, M Stapelberg, M. Lee, Geoffrey W. McCaughan, Thomas Tu, Magdalena A. Budzinska, James G. Kench, Nicholas A. Shackel, R Lam, Jacob George
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
Despite advances in antiviral therapy, molecular drivers of Hepatitis C Virus (HCV)-related liver disease remain poorly characterised. Chronic infection with HCV genotypes (1 and 3) differ in presentation of liver steatosis and virological response t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5141aa3e4088ee8f7c2e63c1830ec9d8
http://link.springer.com/article/10.1038/s41598-019-46664-0
http://link.springer.com/article/10.1038/s41598-019-46664-0
Autor:
Narci C Teoh, Hussam Ajamieh, Heng Jian Wong, Kevin Croft, Trevor Mori, Anthony C Allison, Geoffrey C Farrell
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e104376 (2014)
BACKGROUND & AIMS: Ischemia-reperfusion injury (IRI) can cause hepatic failure after liver surgery or transplantation. IRI causes oxidative stress, which injures sinusoidal endothelial cells (SECs), leading to recruitment and activation of Kupffer ce
Externí odkaz:
https://doaj.org/article/dea33627964546ca9ae690a81730c829
Autor:
Prajna Anirvan, Geoffrey C. Farrell, Mamun Al-Mahtab, Giulio Marchesini, Shivaram Prasad Singh, Guruprasad P. Aithal, Khean-Lee Goh, Anuradha S Dassanayake, Stephen H. Caldwell, Sanjaya K. Satapathy, K. Rajender Reddy, Kaushal Madan, Maria Letizia Petroni, Hari S. Conjeevaram, Saeed Hamid, Ajay Duseja, Subrat K. Acharya, Mary E. Rinella
Publikováno v:
Journal of hepatology. 74(4)
There has been a concerted effort to change the nomenclature of non-alcoholic fatty liver disease (NAFLD) to metabolic dysfunction-associated fatty liver disease (MAFLD), and one wonders if it is appropriate and timely to bid adieu to the good old te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb874db364a04dfdb3626b209a07cfb
https://pubmed.ncbi.nlm.nih.gov/33453331
https://pubmed.ncbi.nlm.nih.gov/33453331