Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Geoffrey B. Varty"'
Autor:
Anna-Mari Karkkainen, Philip Manfre, Elaine O’Loughlin, Juha Kuosmanen, Gonzalo Zeballos Zeballos, Kimmo Lehtimäki, Binod Jacob, Takayuki Tsuchiya, Geoffrey B. Varty, Matthew E. Kennedy, Nicholas T Gatto, Thomas W. Rosahl, Sophia Bardehle, Christian Mirescu, Anjali McCullough
Advances in our understanding of cellular functions and phenotypes in the brain rely on technically robust experimental in vivo models with face validity towards human disease. The cuprizone toxin-induced demyelination model is widely used to investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26d07f472de9c117ab0bb2ba15fbe88e
https://doi.org/10.1101/2020.12.17.423334
https://doi.org/10.1101/2020.12.17.423334
Autor:
Steven M, Grauer, Raul, Sanoja, Dominic, Poulin, Harunor, Rashid, Nina, Jochnowitz, Michael, Calhoun, Daniel, Zwilling, Geoffrey B, Varty, Thomas W, Rosahl, Hamid, Meziane, Christopher, Mittlelhaeuser, Robert, Mazzola, John, Morrow, Sean M, Smith, Darrell, Henze, Jacob, Marcus
Publikováno v:
Brain research. 1737
Analgesic properties of orthosteric agonists of the muscarinic M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::18a3b567ecce3e5da46e53e30820eeee
https://pubmed.ncbi.nlm.nih.gov/32234514
https://pubmed.ncbi.nlm.nih.gov/32234514
Autor:
John A. Morrow, Raul Sanoja, Jacob Marcus, Daniel Zwilling, Darrell A. Henze, Nina Jochnowitz, Christopher Mittlelhaeuser, Robert Mazzola, Michael Calhoun, Hamid Meziane, Harunor Rashid, Dominic Poulin, Sean M. Smith, Thomas W. Rosahl, Geoffrey B. Varty, Steven M. Grauer
Publikováno v:
Brain Research. 1737:146814
Analgesic properties of orthosteric agonists of the muscarinic M4 receptor subtype have been documented in literature reports, with evidence from pharmacological and in vivo receptor knock out (KO) studies. Constitutive M4 receptor KO mice demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0755978bfdbf1967ba6a279f3bba5d8
https://doi.org/10.1016/j.brainres.2020.146814
https://doi.org/10.1016/j.brainres.2020.146814
Autor:
Sherry X. Lu, Eric M. Parker, Mario Guzzi, Robert A. Hodgson, Xiaoping Zhang, Michael W. Miller, Andrew Stamford, Carina J. Bleickardt, Geoffrey B. Varty, Jack D. Scott, Deborra Mullins
Publikováno v:
European Journal of Pharmacology. 730:157-163
Overactivity of the hypothalamic-pituitary-adrenal (HPA) axis has been linked to affective disorders such as anxiety and depression. Dampening HPA activity has, therefore, been considered as a possible means of treating affective disorders. Given the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b63790802699346bcb765c3bc76a8cd9
https://doi.org/10.1016/j.ejphar.2014.02.027
https://doi.org/10.1016/j.ejphar.2014.02.027
Autor:
Mark D. Black, Denis Boulay, Rosy Sher, Guy Griebel, Sukhveen Sahni, Robert E. Featherstone, Franck Slowinski, Sathapana Kongsamut, Vanessa Naimoli, C. Desvignes, Kosley Raymond W, Geoffrey B. Varty, Xavier Vigé, Olivier Bergis, Lisa Potestio, Philippe Pichat, Henry Defex
Publikováno v:
Scientific Reports
Normalization of altered glutamate neurotransmission through activation of the mGluR2 has emerged as a new approach to treat schizophrenia. These studies describe a potent brain penetrant mGluR2 positive allosteric modulator (PAM), SAR218645. The com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b3deb4b4ce55cdb0ce6ba96cb6cdcf
https://doi.org/10.1038/srep35320
https://doi.org/10.1038/srep35320
Autor:
Sandra Beeské, Ina Weiner, Mark D. Black, Michal Arad, Geoffrey B. Varty, Antonio Castro, Marie-Pierre Pruniaux, Elisabeth Genet, Etienne Guillot, Guy Griebel, Philippe Pichat, Segev Barak, Mati Lopez-Grancha, Terranova Jean-Paul, Amaya De Levie, Juan Antonio Sánchez
Publikováno v:
Pharmacology Biochemistry and Behavior. 102:203-214
SAR110894 is a novel histamine H₃-R ligand, displaying high and selective affinity for human, rat or mouse H₃-Rs. SAR110894 is a potent H₃-R antagonist at native receptors, reversing R-α-methylhistamine-induced inhibition of electrical field s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50f3718ac3b8431a2c61abfc2c200018
https://doi.org/10.1016/j.pbb.2012.04.004
https://doi.org/10.1016/j.pbb.2012.04.004
Autor:
Jean E. Lachowicz, Geoffrey B. Varty, Robert J. Naylor, Guy A. Higgins, Eric M. Parker, Cynthia A. Morgan, Ruth A. Duffy
Publikováno v:
Pharmacology Biochemistry and Behavior. 102:95-100
NK1 receptor antagonists have been shown to have a variety of physiological and potential therapeutic effects in animal models and in humans. The present studies demonstrate that Rolapitant (SCH 619734, (5S)-8(S)-[[1(R)-[3,5 bis(trifluoromethyl)pheny
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e28e3b293969e6ef53f92a6d13634048
https://doi.org/10.1016/j.pbb.2012.03.021
https://doi.org/10.1016/j.pbb.2012.03.021
Autor:
Sherry X. Lu, Carina J. Bleickardt, Donald H. Guthrie, Robert A. Hodgson, Geoffrey B. Varty, Eric M. Parker, Prescott T. Leach, Lynn A. Hyde, Mary Cohen-Williams, Tatiana M. Kazdoba
Publikováno v:
Pharmacology Biochemistry and Behavior. 98:181-187
Metabotropic glutamate receptor 1 (mGluR1) antagonists interfere with learning and memory; however, their role in motor function is not well elucidated despite their abundance in brain areas implicated in the control of movement. Here, the effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860e909bcee4856131d6cee8f1b39eed
https://doi.org/10.1016/j.pbb.2010.11.018
https://doi.org/10.1016/j.pbb.2010.11.018
Autor:
Abdallah Hadj-Tahar, Robert A. Hodgson, Thérèse Di Paolo, Tatiana M. Kazdoba, Andrew Stamford, Paul J. Bédard, Annamarie Pond, Aurelie Dare, Laurent Grégoire, John C. Hunter, Geoffrey B. Varty, Michael Grzelak, Bernard R. Neustadt, Nancy Bélanger
Publikováno v:
Experimental Neurology. 225:384-390
Parkinson's Disease (PD) and Extrapyramidal Syndrome (EPS) are movement disorders that result from degeneration of the dopaminergic input to the striatum and chronic inhibition of striatal dopamine D(2) receptors by antipsychotics, respectively. Aden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a259cd1902b557fbeef2d74fff789ae2
https://doi.org/10.1016/j.expneurol.2010.07.011
https://doi.org/10.1016/j.expneurol.2010.07.011
Autor:
Tony Priestley, Vaccaro Henry A, Andrew Stamford, Deborra E Mullins, Michael W. Miller, Tin-Yau Chan, Robert A. Hodgson, Scott Jack D, William J. Greenlee, Liwu Hong, Mario Guzzi, Sarah W. Li, Eric M. Parker, Geoffrey B. Varty, Jay Weinstein, Sue-Ing Lin, Mckittrick Brian A
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6018-6022
Vasopressin 1b (V1b) antagonists have been postulated as possible treatments for depression and anxiety. A novel series of potent and selective V1b antagonists has been identified starting from an in-house screen hit. The incorporation of a sulfonami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a1a83509d9b8d8b7220d92453c7462a
https://doi.org/10.1016/j.bmcl.2009.09.050
https://doi.org/10.1016/j.bmcl.2009.09.050