Zobrazeno 1 - 10
of 318
pro vyhledávání: '"Geoffrey B. Jameson"'
Autor:
Maksim V. Kvach, Stefan Harjes, Harikrishnan M. Kurup, Geoffrey B. Jameson, Elena Harjes, Vyacheslav V. Filichev
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 1088-1098 (2024)
Nucleoside and polynucleotide cytidine deaminases (CDAs), such as CDA and APOBEC3, share a similar mechanism of cytosine to uracil conversion. In 1984, phosphapyrimidine riboside was characterised as the most potent inhibitor of human CDA, but the qu
Externí odkaz:
https://doaj.org/article/3054820e05924e07b1987d9f1948b5dd
Autor:
Stefan Harjes, Harikrishnan M. Kurup, Amanda E. Rieffer, Maitsetseg Bayarjargal, Jana Filitcheva, Yongdong Su, Tracy K. Hale, Vyacheslav V. Filichev, Elena Harjes, Reuben S. Harris, Geoffrey B. Jameson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The normally antiviral enzyme APOBEC3A is an endogenous mutagen in human cancer. Its single-stranded DNA C-to-U editing activity results in multiple mutagenic outcomes including signature single-base substitution mutations (isolated and clus
Externí odkaz:
https://doaj.org/article/dee127bc8f2a4f0a80fc7da79084398b
Autor:
D. Nirosha T. De Silva, Tyson N. Dais, Geoffrey B. Jameson, Casey G. Davies, Guy N. L. Jameson, Paul G. Plieger
Publikováno v:
Molecules, Vol 29, Iss 13, p 3218 (2024)
The syntheses, coordination chemistry, and Mössbauer spectroscopy of hepta-iron(III) complexes using derivatised salicylaldoxime ligands from two categories; namely, ‘single-headed’ (H2L) and ‘double-headed’ (H4L) salicylaldoximes are descri
Externí odkaz:
https://doaj.org/article/cbb6ca3f7d974ff4a751bc7aeae110ac
Publikováno v:
ACS Omega, Vol 7, Iss 7, Pp 6427-6435 (2022)
Externí odkaz:
https://doaj.org/article/6bed31ecaea944209e0d566f8ad918e9
Autor:
D. Nirosha T. De Silva, Tyson N. Dais, Geoffrey B. Jameson, Daniel J. Cutler, Euan K. Brechin, Casey G. Davies, Guy N. L. Jameson, Paul G. Plieger
Publikováno v:
ACS Omega, Vol 6, Iss 25, Pp 16661-16669 (2021)
Externí odkaz:
https://doaj.org/article/525c510ab96c40cc8f3f2e91f990d743
Publikováno v:
Molecules, Vol 28, Iss 8, p 3573 (2023)
In this study, sodium caseinate (NaCas), soy protein isolate (SPI), and whey protein isolate (WPI) were used as structural materials for the delivery of rutin, naringenin, curcumin, hesperidin, and catechin. For each polyphenol, the protein solution
Externí odkaz:
https://doaj.org/article/53e0734f0c184720855047dff49d9f9d
Publikováno v:
Biophysical Reports, Vol 2, Iss 1, Pp 100045- (2022)
Optical tweezers-based DNA stretching often relies on tethering a single end-activated DNA molecule between optically manipulated end-binding beads. Measurement success can depend on DNA concentration. At lower DNA concentrations tethering is less co
Externí odkaz:
https://doaj.org/article/cf41314a38c2447086ad35f2bc2846ee
Autor:
Fareeda M. Barzak, Timothy M. Ryan, Nazanin Mohammadzadeh, Stefan Harjes, Maksim V. Kvach, Harikrishnan M. Kurup, Kurt L. Krause, Linda Chelico, Vyacheslav V. Filichev, Elena Harjes, Geoffrey B. Jameson
Publikováno v:
Viruses, Vol 14, Iss 9, p 1974 (2022)
APOBEC3 enzymes are polynucleotide deaminases, converting cytosine to uracil on single-stranded DNA (ssDNA) and RNA as part of the innate immune response against viruses and retrotransposons. APOBEC3G is a two-domain protein that restricts HIV. Altho
Externí odkaz:
https://doaj.org/article/e6bb7a035b1541ab907a372338d6e150
Publikováno v:
Molecules, Vol 27, Iss 2, p 534 (2022)
Poor water solubility and low bioavailability of hydrophobic flavonoids such as rutin remain as substantial challenges to their oral delivery via functional foods. In this study, the effect of pH and the addition of a protein (sodium caseinate; NaCas
Externí odkaz:
https://doaj.org/article/1ed9da11f7b24a65a198f414461751b7
Autor:
Harikrishnan M. Kurup, Maksim V. Kvach, Stefan Harjes, Fareeda M. Barzak, Geoffrey B. Jameson, Elena Harjes, Vyacheslav V. Filichev
Publikováno v:
Biochemistry. 61:2568-2578
Drug resistance is a major problem associated with anticancer chemo- and immunotherapies. Recent advances in the understanding of resistance mechanisms have revealed that enzymes of the APOBEC3 (A3) family contribute to the development of drug resist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::771bf11138882bba41d266a0f16bd4a3
https://doi.org/10.1021/acs.biochem.2c00449
https://doi.org/10.1021/acs.biochem.2c00449