Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Geoffrey A. McKay"'
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Stressors and environmental cues shape the physiological state of bacteria, and thus how they subsequently respond to antibiotic toxicity. To understand how superoxide stress can modulate survival to bactericidal antibiotics, we examined the effect o
Externí odkaz:
https://doaj.org/article/4a84775536ed4329a3896037d667175f
Autor:
Lisa C Hennemann, Shantelle L LaFayette, Julien K Malet, Perrine Bortolotti, Tianxiao Yang, Geoffrey A McKay, Daniel Houle, Danuta Radzioch, Simon Rousseau, Dao Nguyen
Publikováno v:
PLoS Pathogens, Vol 17, Iss 3, p e1009375 (2021)
Pseudomonas aeruginosa causes chronic airway infections, a major determinant of lung inflammation and damage in cystic fibrosis (CF). Loss-of-function lasR mutants commonly arise during chronic CF infections, are associated with accelerated lung func
Externí odkaz:
https://doaj.org/article/bf90d258e3c04ab581f8f7448141615d
Autor:
André R. Paquette, Sterling R. Payne, Geoffrey A. McKay, Jordan T. Brazeau-Henrie, Micheal G. Darnowski, Anitha Kammili, Federico Bernal, Thien-Fah Mah, Samantha Gruenheid, Dao Nguyen, Christopher N. Boddy
Publikováno v:
RSC Medicinal Chemistry. 13:445-455
Optimized RpoN-based stapled peptides selectively bind promoter DNA sequence and inhibit virulence of Pseudomonas aeruginosa in an in vivo model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dba7e113a6d590d6fe5209babed9e7b5
https://doi.org/10.1039/d1md00371b
https://doi.org/10.1039/d1md00371b
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Cyanophycin is a bacterial polymer mainly used for nitrogen storage. It is composed of a peptide backbone of L-aspartate residues with L-arginines attached to their side chains through isopeptide bonds. Cyanophycin is degraded in two steps: Cyanophyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed550135e9c2bce2e689ef6a6744fb23
https://doi.org/10.1073/pnas.2216547120
https://doi.org/10.1073/pnas.2216547120
Autor:
André R, Paquette, Sterling R, Payne, Geoffrey A, McKay, Jordan T, Brazeau-Henrie, Micheal G, Darnowski, Anitha, Kammili, Federico, Bernal, Thien-Fah, Mah, Samantha, Gruenheid, Dao, Nguyen, Christopher N, Boddy
Publikováno v:
RSC Med Chem
Stapled peptides have the ability to mimic α-helices involved in protein binding and have proved to be effective pharmacological agents for disrupting protein–protein interactions. DNA-binding proteins such as transcription factors bind their cogn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3900fc49366b67abb1dccde6e4c96262
https://pubmed.ncbi.nlm.nih.gov/35647551
https://pubmed.ncbi.nlm.nih.gov/35647551
Autor:
Gregory Moeck, Sylvain Beaulieu, Ingrid Sarmiento, Francis F. Arhin, Geoffrey A. McKay, Thomas R. Parr
Publikováno v:
International Journal of Antimicrobial Agents. 34:550-554
The activity of oritavancin in vitro against recent clinical isolates of Streptococcus pyogenes, including antibiotic-resistant strains, was characterised by determination of broth microdilution minimal inhibitory concentrations as well as time-kill
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b5b26f3e10691201b6ac0950490cbb1
https://doi.org/10.1016/j.ijantimicag.2009.08.012
https://doi.org/10.1016/j.ijantimicag.2009.08.012
Autor:
Francis F. Arhin, Gregory Moeck, Thomas R. Parr, Ingrid Sarmiento, Geoffrey A. McKay, Sylvain Beaulieu
Publikováno v:
Diagnostic Microbiology and Infectious Disease. 65:207-210
Human serum albumin (HSA) did not affect oritavancin MICs against non–vancomycin-intermediate Staphylococcus aureus (non-VISA) strains. In time–kill assays, oritavancin bactericidal activity in the presence of HSA was significantly more rapid tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd6e9f37c7db02584746fd67510e74a6
https://doi.org/10.1016/j.diagmicrobio.2009.05.022
https://doi.org/10.1016/j.diagmicrobio.2009.05.022
Autor:
Gregory Moeck, Geoffrey A. McKay, Robert J. Harris, Thomas R. Parr, Eve Neesham-Grenon, Adam Belley, Terry J. Beveridge, Francis F. Arhin
Publikováno v:
Antimicrobial Agents and Chemotherapy. 53:918-925
Slow-growing bacteria and biofilms are notoriously tolerant to antibiotics. Oritavancin is a lipoglycopeptide with multiple mechanisms of action that contribute to its bactericidal action against exponentially growing gram-positive pathogens, includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9c950ab94f0cc5940b0b3c85fb11218
https://doi.org/10.1128/aac.00766-08
https://doi.org/10.1128/aac.00766-08
Autor:
Ingrid Sarmiento, Thomas R. Parr, Gregory Moeck, Deborah C. Draghi, Daniel F. Sahm, Adam Belley, Parveen Grover, Francis F. Arhin, Geoffrey A. McKay
Publikováno v:
Antimicrobial Agents and Chemotherapy. 52:1597-1603
Oritavancin, a semisynthetic lipoglycopeptide with activity against gram-positive bacteria, has multiple mechanisms of action, including the inhibition of cell wall synthesis and the perturbation of the membrane potential. Approved guidelines for bro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dda439994ab37f718b10daa5d1e5b68
https://doi.org/10.1128/aac.01513-07
https://doi.org/10.1128/aac.01513-07
Autor:
Stephane Ciblat, Ranga Reddy, Geoffrey A. McKay, Jerry Pelletier, Daniel M. Williams, Adel Rafai Far, Odette Belanger, Francis F. Arhin, Jing Liu, Dilip Dixit, Thomas R. Parr, Yannick Rose, Kelly S.E. Tanaka, Mohammed Dehbi, Evelyne Dietrich, Daniel Delorme, Ramakrishnan Srikumar, Yanick Lafontaine, Dario Lehoux, Philippe Gros, Greg Moeck
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:5812-5832
The RNA polymerase holoenzyme is a proven target for antibacterial agents. A high-throughput screening program based on this enzyme from Staphylococcus aureus had previously identified a 2-ureidothiophene-3-carboxylate as a low micromolar inhibitor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f17d3fa25f3945a6e85410ea13e86501
https://doi.org/10.1016/j.bmc.2006.05.035
https://doi.org/10.1016/j.bmc.2006.05.035