Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Geoffrey A Walford"'
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0229280 (2020)
Natriuretic peptides are cardiac-derived hormones that enhance insulin sensitivity and reduce fat accumulation. Low natriuretic peptide levels are associated with increased risk of type 2 diabetes mellitus (DM2); a condition with variable prevalence
Externí odkaz:
https://doaj.org/article/b314d6c4dc52459493ba8670de66802a
Autor:
Geoffrey A Walford, Natalia Colomo, Jennifer N Todd, Liana K Billings, Marlene Fernandez, Bindu Chamarthi, A Sofia Warner, Jaclyn Davis, Katherine R Littleton, Alicia M Hernandez, Rebecca R Fanelli, Amelia Lanier, Corinne Barbato, Rachel J Ackerman, Sabina Q Khan, Rosa Bui, Laurel Garber, Elliot S Stolerman, Allan F Moore, Chunmei Huang, Varinderpal Kaur, Maegan Harden, Andrew Taylor, Ling Chen, Alisa K Manning, Paul Huang, Deborah Wexler, Rita M McCarthy, Janet Lo, Melissa K Thomas, Richard W Grant, Allison Goldfine, Margo S Hudson, Jose C Florez
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121553 (2015)
Genome-wide association studies have uncovered a large number of genetic variants associated with type 2 diabetes or related phenotypes. In many cases the causal gene or polymorphism has not been identified, and its impact on response to anti-hypergl
Externí odkaz:
https://doaj.org/article/0b9d642396cf47848d3354e4f5246c20
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 1, Pp n/a-n/a (2024)
Abstract Phase I trials inform on the initial safety profile of a new molecule and impact whether further development is pursued or not. Understanding the effect of non‐pharmacological factors on the variability of routine safety parameters could i
Externí odkaz:
https://doaj.org/article/60784f8b691e4424a7b3470869b534a3
Autor:
Richard A. Jensen, Denis Rybin, Jaakko Tuomilehto, Reedik Mägi, Inga Prokopenko, Jeffrey R. O'Connell, Marcus E. Kleber, Han Chen, Geoffrey A. Walford, Allan Linnenberg, Anke Tönjes, Francis S. Collins, Sonsoles Morcillo, Gemma Rojo-Martínez, Kenneth Rice, Jose C. Florez, Leif Groop, Manuel Serrano-Ríos, Josée Dupuis, Alisa K. Manning, Peter Kovacs, Torben Jørgensen, Graciela E. Delgado, Alena Stančáková, Hans-Ulrich Häring, Claudia Langenberg, Joshua P. Lewis, Norbert Stefan, Markku Laakso, Torben Hansen, Bruce M. Psaty, Jian'an Luan, Michael Stumvoll, Mark O. Goodarzi, Robert A. Scott, Oluf Pedersen, Ching-Ti Liu, Michael N. Weedon, Michael Boehnke, Ulf Smith, David S. Siscovick, Aaron Leong, Weijia Xie, James B. Meigs, Claes Landenvall, Anne U. Jackson, Joseph M. Zmuda, Mary L. Biggs, Jerome I. Rotter, Federico Soriguer, Winfried März, Zhongyang Zhang, May E. Montasser, Arturo Corbatón-Anchuelo, J M Gómez-Zumaquero, Günther Silbernagel, Kristine Færch, Karen L. Mohlke, Heikki A. Koistinen, Yii-Der Ida Chen, Jaeyoung Hong, Gracia María Martín-Núñez, María Teresa Martínez-Larrad, Emil V. R. Appel, Niels Grarup, Harald Staiger, Johanna Kuusisto, Lars Lind, Nicholas J. Wareham, Andreas Fritsche, Stefan Gustafsson, Andrew P. Morris, Richard N. Bergman, Mark Walker, Cecilia M. Lindgren, Erik Ingelsson, Jorge R. Kizer, Timothy M. Frayling, Fausto Machicao
Publikováno v:
Diabetes
Walford, G A, Gustafsson, S, Rybin, D, Stančáková, A, Chen, H, Liu, C-T, Hong, J, Jensen, R A, Rice, K, Morris, A P, Mägi, R, Tönjes, A, Prokopenko, I, Kleber, M E, Delgado, G, Silbernagel, G, Jackson, A U, Appel, E V, Grarup, N, Lewis, J P, Montasser, M E, Landenvall, C, Staiger, H, Luan, J, Frayling, T M, Weedon, M N, Xie, W, Morcillo, S, Martínez-Larrad, M T, Biggs, M L, Ida Chen, Y-D, Corbaton-Anchuelo, A, Færch, K, Zumaquero, J M, Goodarzi, M O, Kizer, J, Koistinen, H A, Leong, A, Lind, L, Lindgren, C, Machicao, F, Manning, A K, Martín-Núñez, G M, Rojo-Martínez, G, Rotter, J I, Siscovick, D S, Zmuda, J M, Zhang, Z, Serrano-Rios, M, Smith, U, Soriguer, F, Hansen, T, Jørgensen, T J, Linnenberg, A, Pedersen, O, Walker, M, Langenberg, C, Scott, R A, Wareham, N J, Fritsche, A, Häring, H-U, Stefan, N, Groop, L, O'Connell, J R, Boehnke, M, Bergman, R N, Collins, F S, Mohlke, K L, Tuomilehto, J, März, W, Kovacs, P, Stumvoll, M, Psaty, B M, Kuusisto, J, Laakso, M, Meigs, J B, Dupuis, J, Ingelsson, E & Florez, J C 2016, ' Genome-wide association study of the modified Stumvoll Insulin Sensitivity Index identifies BCL2 and FAM19A2 as novel insulin sensitivity loci ', Diabetes, vol. 65, no. 10, pp. 3200-3211 . https://doi.org/10.2337/db16-0199
DIABETES
Walford, G A, Gustafsson, S, Rybin, D, Stančáková, A, Chen, H, Liu, C-T, Hong, J, Jensen, R A, Rice, K, Morris, A P, Mägi, R, Tönjes, A, Prokopenko, I, Kleber, M E, Delgado, G, Silbernagel, G, Jackson, A U, Appel, E V, Grarup, N, Lewis, J P, Montasser, M E, Landenvall, C, Staiger, H, Luan, J, Frayling, T M, Weedon, M N, Xie, W, Morcillo, S, Martínez-Larrad, M T, Biggs, M L, Ida Chen, Y-D, Corbaton-Anchuelo, A, Færch, K, Zumaquero, J M, Goodarzi, M O, Kizer, J, Koistinen, H A, Leong, A, Lind, L, Lindgren, C, Machicao, F, Manning, A K, Martín-Núñez, G M, Rojo-Martínez, G, Rotter, J I, Siscovick, D S, Zmuda, J M, Zhang, Z, Serrano-Rios, M, Smith, U, Soriguer, F, Hansen, T, Jørgensen, T J, Linnenberg, A, Pedersen, O, Walker, M, Langenberg, C, Scott, R A, Wareham, N J, Fritsche, A, Häring, H-U, Stefan, N, Groop, L, O'Connell, J R, Boehnke, M, Bergman, R N, Collins, F S, Mohlke, K L, Tuomilehto, J, März, W, Kovacs, P, Stumvoll, M, Psaty, B M, Kuusisto, J, Laakso, M, Meigs, J B, Dupuis, J, Ingelsson, E & Florez, J C 2016, ' Genome-wide association study of the modified Stumvoll Insulin Sensitivity Index identifies BCL2 and FAM19A2 as novel insulin sensitivity loci ', Diabetes, vol. 65, no. 10, pp. 3200-3211 . https://doi.org/10.2337/db16-0199
DIABETES
Genome-wide association studies (GWAS) have found few common variants that influence fasting measures of insulin sensitivity. We hypothesized that a GWAS of an integrated assessment of fasting and dynamic measures of insulin sensitivity would detect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb835e572112710c128ad103623be68
Autor:
Nicole Landa Cavallaro, Jamie Garry, Xu Shi, Robert E. Gerszten, Ellen J. Anderson, Geoffrey A. Walford
Publikováno v:
Food & Nutrition Research, Vol 60, Iss 0, Pp 1-9 (2016)
Background: Elevated fasting levels of branched chain amino acids (BCAAs: valine, isoleucine, leucine) in venous blood are associated with a variety of metabolic impairments, including increased risk of type 2 diabetes (T2D). Fasting BCAA levels are
Externí odkaz:
https://doaj.org/article/4334c8ba59a74752ad29c0ace6e12e21
Autor:
Geoffrey A. Walford, Kelly E. Duncan, Moises Hernandez, Pavan Vaddady, Marcus Hompesch, Linda Morrow, S. Aubrey Stoch
Publikováno v:
Clinical pharmacology and therapeutics. 112(1)
Insulin molecules of size much greater than natural insulin have been synthesized and studied with the intention of widening the therapeutic window between adequate glycemic control and hypoglycemia as compared with conventional insulins. MK-1092 is
Autor:
Yuan-Di C. Halvorsen, Geoffrey A. Walford, Mason W. Freeman, Heidy Russell, Monica Massaro, Tara K. Thurber
Publikováno v:
Diabetes, Obesity and Metabolism. 22:566-573
AIM To compare the safety and efficacy of bexagliflozin administered as monotherapy at three dosage strengths over a 12-week period to patients with type 2 diabetes who were either naive to pharmacotherapy or were previously prescribed one oral hypog
Autor:
Yuan-Di C. Halvorsen, Robert P Aftring, Geoffrey A. Walford, Joseph M. Massaro, Mason W. Freeman
Publikováno v:
Diabetes, Obesity and Metabolism. 21:2496-2504
AIM To explore the safety and effectiveness of extended exposure to bexagliflozin as a monotherapy for type 2 diabetes. METHODS Adults with diabetes (n = 288) from the USA, Colombia and Mexico were randomized 1:1 to receive bexagliflozin (20 mg) or p
Autor:
Luz E. Guillen Pineda, Ernesto Roldan-Valadez, Jannette Furuzawa-Carballeda, Suzanne B.R. Jacobs, Patricia Clark, Ivette Cruz-Bautista, Ma. Luisa Ordonez-Sanchez, Alexandro J Martagón Rosado, Jose C. Florez, Elena Zambrano, Tannia Viveros Ruiz, Paloma Almeda-Valdes, Joaquin Azpiroz, Alicia Huerta-Chagoya, Donaji V Gómez Velasco, Magdalena del Rocío Sevilla-González, Claudia J Bautista, Carlos A. Aguilar-Salinas, Karen Guadalupe Rodríguez-Álvarez, Liliana Muñoz Hernandez, Hortensia Moreno-Macías, Miguel Herrera-Hernandez, Olimpia Arellano Campos, Geoffrey A. Walford, María Teresa Tusié Luna, Omar Yaxmehen Bello-Chavolla
Publikováno v:
European Journal of Endocrinology. 180:99-107
Objective A haplotype at chromosome 17p13 that reduces expression and function of the solute carrier transporter SLC16A11 is associated with increased risk for type 2 diabetes in Mexicans. We aim to investigate the detailed metabolic profile of SLC16
Racial/ethnic differences in circulating natriuretic peptide levels: The Diabetes Prevention Program
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 2, p e0229280 (2020)
PLoS ONE, Vol 15, Iss 2, p e0229280 (2020)
Natriuretic peptides are cardiac-derived hormones that enhance insulin sensitivity and reduce fat accumulation. Low natriuretic peptide levels are associated with increased risk of type 2 diabetes mellitus (DM2); a condition with variable prevalence