Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Geoffrey, Butcher"'
Autor:
Stephen M. Laidlaw, Geoffrey Butcher, Eric G. Sheu, Adrian V. S. Hill, Sarah C. Gilbert, Richard J. Anderson, Michael A. Skinner, Robert E. Sinden, Simone Korten, Carolyn M. Hannan
Publikováno v:
Scopus-Elsevier
Sterile immunity can be provided against the pre-erythrocytic stages of malaria by IFN-γ-secreting CD8+ T cells that recognize parasite-infected hepatocytes. In this study, we have investigated the use of attenuated fowlpox virus (FPV) strains as re
Autor:
Geoffrey Butcher, Jörg Schneider, Tom Blanchard, Geoffrey L. Smith, Guy T. Layton, Carolyn M. Hannan, Marion Becker, Magdalena Plebanski, Adrian V. S. Hill, Sarah C. Gilbert, Robert E. Sinden
Publikováno v:
European Journal of Immunology. 28:4345-4355
The desirability of inducing cytotoxic T cell responses to defined epitopes in humans has led to the development of a variety of recombinant delivery systems. Recombinant protein particles derived from a yeast retrotransposon (Ty) and the modified An
Autor:
Andrew M, Blagborough, Michael J, Delves, Chandra, Ramakrishnan, Kalpana, Lal, Geoffrey, Butcher, Robert E, Sinden
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 923
Here we describe a series of methods that can be used to assess the activities of "vaccines," drugs, and genetically modified vectors, for their abilities to inhibit transmission of Plasmodium from its vertebrate to its mosquito hosts. The selection
Autor:
Kalpana Lal, Kenneth W. Baker, Andrew M. Blagborough, Robert E. Sinden, Chandra Ramakrishnan, Michael J. Delves, Geoffrey Butcher
Publikováno v:
Methods in Molecular Biology ISBN: 9781627030250
We provide a series of protocols that have been used for the cyclic transmission of rodent malaria parasites in the laboratory. This is now possible both in vivo and in vitro. We focus on the least "resource intensive" and generic methods that we fin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc3f7350e9fdb5267b041653d5b6826
https://doi.org/10.1007/978-1-62703-026-7_5
https://doi.org/10.1007/978-1-62703-026-7_5
Publikováno v:
Malaria Journal, Vol 6, Iss 1, p 77 (2007)
Malaria Journal
Malaria Journal
BackgroundInvestigation of host responses to blood stages of Plasmodium spp, and the immunopathology associated with this phase of the life cycle are often performed on mice infected directly with infected red blood cells. Thus, the effects of mosqui
Autor:
Stephen Todryk, Filip Dubovsky, Fiona M. Thompson, Eveline L. Tierney, Ian D. Poulton, Laura Andrews, Tamara Berthoud, Anne C. Moore, Robert E. Sinden, Simon Correa, Michael Walther, Sheila M. Keating, Geoffrey Butcher, Jack Williams, Adrian V. S. Hill, Sarah C. Gilbert, Rikke Fredslund Andersen, Susanna Dunachie, Angela Hunt-Cooke
Publikováno v:
Europe PubMed Central
Heterologous prime-boost immunization with DNA and various recombinant poxviruses encoding malaria antigens is capable of inducing strong cell-mediated immune responses and partial protection in human sporozoite challenges. Here we report a series of
Autor:
Susanna J, Dunachie, Michael, Walther, Jenni M, Vuola, Daniel P, Webster, Sheila M, Keating, Tamara, Berthoud, Laura, Andrews, Philip, Bejon, Ian, Poulton, Geoffrey, Butcher, Katherine, Watkins, Robert E, Sinden, Amanda, Leach, Philippe, Moris, Nadia, Tornieporth, Joerg, Schneider, Filip, Dubovsky, Eveline, Tierney, Jack, Williams, D Gray, Heppner, Sarah C, Gilbert, Joe, Cohen, Adrian V S, Hill
Publikováno v:
Vaccine. 24(15)
Heterologous prime-boost immunisation with RTS,S/AS02A and the poxvirus MVA-CS was evaluated in 18 healthy malaria-naïve subjects in Oxford. Both priming with RTS,S and boosting MVA-CS, and the reverse, were found to be safe and well tolerated. T ce
Autor:
Susanna Dunachie, Robert E. Sinden, Jenni M. Vuola, Angela Hunt-Cooke, Ian D. Poulton, Carolin Maier, Eveline L. Tierney, Tamara Berthoud, Sheila M. Keating, George B. Thornton, Filip Dubovsky, Daniel P. Webster, Geoffrey Butcher, Simon Correa, Adrian V. S. Hill, Sarah C. Gilbert, Rikke Fredslund Andersen, Michael Walther, Annette Schmidt, Laura Andrews, Pramod Sarpotdar, Jack Williams
Publikováno v:
Vaccine. 23(7)
ICC-1132, a recombinant virus-like particle comprising of a modified hepatitis B core protein with a B cell (NANP) and two T cell epitopes of Plasmodium falciparum circumsporozoite protein (CSP), was administered i.m. as a single 50 microg dose in Se
Publikováno v:
Microbes and infection. 5(4)
The development of in vitro culture systems for the vertebrate stages of Plasmodium led to major advancements in malaria research. Here we review both improvements made in these techniques and the recent achievement of the in vitro growth of mosquito
P25 and P28 proteins of the malaria ookinete surface have multiple and partially redundant functions
Autor:
Pietro Lupetti, Gabriele Margos, Chris J. Janse, Maria del Carmen Rodriguez, George Dimopoulos, Geoffrey Butcher, Marianna Karras, Tania F. de Koning-Ward, Annette L. Beetsma, Ana M. Tomás, Leo H.M. van Lin, Jacqui Mendoza, Andrew P. Waters, Ria Sinha, Robert E. Sinden, Fotis C. Kafatos, Ariadne Hager
Publikováno v:
The EMBO journal. 20(15)
The ookinete surface proteins (P25 and P28) are proven antimalarial transmission-blocking vaccine targets, yet their biological functions are unknown. By using single (Sko) and double gene knock-out (Dko) Plasmodium berghei parasites, we show that P2