Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Geoff T Halvorsen"'
Autor:
Wei Qiu, Qi Sun, Yi Yang, Chirag Patel, Meng Sun, Yue Liu, Kyle Halliwill, Sarah Kim, Rebecca Mathew, Jennifer M Frost, Jennifer A Roth, Domenick Kennedy, Robert T Manguso, Kathleen B Yates, Hakimeh Ebrahimi-Nik, Christina K Baumgartner, Arvin Iracheta-Vellve, Keith M Hamel, Kira Olander, Thomas GR Davis, Kathleen A McGuire, Geoff T Halvorsen, Omar I Avila, Ashwin V Kammula, Audrey J Muscato, Prasanthi Geda, Kelly Klinge, Zhaoming Xiong, Ryan Duggan, Liang Mu, Mitchell D Yeary, James C Patti, Tyler M Balon, Carey Backus, Angeline Chen, Kenton Longenecker, Joseph Klahn, Cara Hrusch, Navasona Krishnan, Charles W Hutchins, Jacqueline Aguado, Marinka Bulic, Payal Tiwari, Kayla J Colvin, Cun Lan Chuong, Ian C Kohnle, Matthew G Rees, Andrew Boghossian, Melissa Ronan, Meng-Ju Wu, Debattama R Sen, Gabriel K Griffin, Nabeel El-Bardeesy, Patricia Trusk, Joshua H Decker, Stacey Fossey, Marcia N Paddock, Elliot P Farney, Clay Beauregard, Philip R Kym
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)
Externí odkaz:
https://doaj.org/article/11356ff1bf1f4b63ab1324cafa253315
Autor:
Hakimeh Ebrahimi-Nik, Arvin Iracheta-Vellve, Kira E. Olander, Thomas R.G. Davis, Sarah Y. Kim, Mitchell D. Yeary, James C. Patti, Tyler M. Balon, Omar Ismail Avila, Cun Lan Chuong, Meng-Ju Wu, Christina K. Baumgartner, Keith M. Hamel, Kathleen A. McGuire, Rebecca Mathew, Carey Backus, Ian C. Kohnle, Zhaoming Xiong, Elliot P. Farney, Jennifer M. Frost, Geoff T. Halvorsen, Matthew Rees, Andrew Boghossian, Melissa Ronan, Jennifer A. Roth, Todd R. Golub, Gabriel K. Griffin, Nabeel El-Bardeesy, Clay C. Beauregard, Philip R. Kym, Kathleen B. Yates, Robert T. Manguso
Publikováno v:
Cancer Immunology Research. 10:A41-A41
Immune checkpoint blockade is effective for a subset of patients across many cancers, but most patients are refractory to current immunotherapies and new approaches are needed to overcome resistance. The protein tyrosine phosphatase PTPN2 is a centra
Autor:
Preethi Krishnan, Rodger F. Henry, Christopher C. Marvin, Tatyana Dekhtyar, Rolf Wagner, John T. Randolph, A. Chris Krueger, David A. Degoey, Vincent Peterkin, Michelle Irvin, Geoff T. Halvorsen, Jason P. Shanley, Heyman Howard R, Eric A. Voight, Robert A. Carr, Cecilia Van Handel, Tongmei Li, Brian S. Brown, Daniel A.J. Bow, Hui-Ju Chen, DeAnne Stolarik
Publikováno v:
Bioorganicmedicinal chemistry. 28(1)
Download : Download high-res image (149KB) Download : Download full-size image Hepatitis C virus (HCV) nucleoside inhibitors have been a key focus of nearly 2 decades of HCV drug research due to a high barrier to drug resistance and pan-genotypic act
Autor:
James G. Granneman, Alex E. Green, Elizabeth A. Rondini, Ljiljana Mladenovic-Lucas, Geoff T. Halvorsen, William R. Roush
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 363:367-376
Current knowledge regarding acute regulation of adipocyte lipolysis is largely based on receptor-mediated activation or inhibition of pathways that influence intracellular levels of cAMP, thereby affecting protein kinase A (PKA) activity. We recently
Publikováno v:
Organic Letters. 19:2490-2493
The room temperature palladium-catalyzed cross-coupling of aromatic and heteroaromatic halides with Reformatsky reagents derived from 1-bromocyclopropanecarboxylates provides an exceptionally mild method for enolate α-arylation. The method is tolera
Autor:
Steven R. Martinez, Geoff T. Halvorsen, Eric G. Moschetta, Eric A. Voight, Michael T. Tudesco, Nathan D. Ide, Albert W. Kruger, Greszler Stephen N, Gang Zhao, Brian S. Brown, Kirill A. Lukin, John Hartung
Publikováno v:
The Journal of organic chemistry. 84(8)
ABBV-168 is a dihalogenated nucleotide under investigation for the treatment of hepatitis C virus. Three synthetic routes aimed at achieving the stereoselective installation of the C2′ gem-Br,F substitution and subsequent Vorbruggen glycosylation w
Autor:
Geoff T. Halvorsen, William R. Roush
Publikováno v:
Organic Letters. 10:5313-5316
The synthesis and intramolecular Diels-Alder reactions of trienes 5 and 6 with a siloxacyclopentene-constrained dienophile are described. These reactions provide the primary cycloadducts 7 and 8 with high diastereoselectivity. These cycloadducts poss
Autor:
Franck Madoux, William R. Roush, Geoff T. Halvorsen, Emilio P. Mottillo, Peter Hodder, Matthew A. Sanders, Joseph A. Caruso, Michelle Angrish, James G. Granneman, Peter Chase, Huamei Zhang, Xiangqun Ye, Ljiljana Mladenovic
Publikováno v:
Cell metabolism. 22(5)
SummaryFat and muscle lipolysis involves functional interactions of adipose triglyceride lipase (ATGL), α-β hydrolase domain-containing protein 5 (ABHD5), and tissue-specific perilipins 1 and 5 (PLIN1 and PLIN5). ABHD5 potently activates ATGL, but
Autor:
Geoff T. Halvorsen, William R. Roush
Publikováno v:
Tetrahedron letters. 52(17)
A stereoselective synthesis of the decahydrofluorene core of the hirsutellones was accomplished in eight steps and in 43% overall yield. The key step of the synthesis is the highly stereoselective intramolecular Diels–Alder cyclization of the silox
Autor:
Geoff T. Halvorsen, William R. Roush
Publikováno v:
ChemInform. 40
The synthesis and intramolecular Diels−Alder reactions of trienes 5 and 6 with a siloxacyclopentene-constrained dienophile are described. These reactions provide the primary cycloadducts 7 and 8 with high diastereoselectivity. These cycloadducts po