Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Geoff R. Hill"'
Autor:
William A. Denny, Stephen M. F. Jamieson, Christian K. Miller, Kate H. Gartlan, Julie Ann Spicer, Jiney Jose, Karshing Chang, Matthew Bull, Hedieh Akhlaghi, Joseph A. Trapani, Jagdish K. Jaiswal, Geoff R. Hill, Patrick D. O'Connor, Anna C. Giddens
Publikováno v:
Journal of Medicinal Chemistry. 63:2229-2239
Perforin is a key effector protein in the vertebrate immune system and is secreted by cytotoxic T lymphocytes and natural killer cells to help eliminate virus-infected and transformed target cells. The ability to modulate perforin activity in vivo co
Autor:
Jasmin Straube, Therese Vu, Leanne Cooper, Richard J D'Andrea, Geoff R. Hill, Megan Bywater, Michael D. Milsom, Sebastien Jacquelin, Shin-Jye Lee, Florian H. Heidel, Lianne I. M. Lansink, Rebecca Austin, Ann Mullally, Joanne Green, Julius Gräsel, Claudia Bruedigam, Steven W. Lane, Nien-Tsu Chen, Gabor Pali, Chung-Wei Lee, Ashraful Haque
Publikováno v:
Leukemia
JAK2V617F is the most common mutation in patients with BCR-ABL negative myeloproliferative neoplasms (MPNs). The eradication of JAK2V617F hematopoietic stem cells (HSCs) is critical for achieving molecular remissions and cure. We investigate the dist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3efd61d329ef1221891f3f699ba3515e
https://europepmc.org/articles/PMC9221569/
https://europepmc.org/articles/PMC9221569/
Autor:
Ping Zhang, Peter Fleming, Christopher Andoniou, Jose Paulo Martins, Alda Saldan, Rachel Kuns, Benjamin McEnroe, Andrea S Henden, Stuart Olver, Adaeze Ekwe, Antiopi Varelias, Corey Smith, Christine R Schmidt, Kathleen S Ensbey, Michael Boeckh, Glen A Kennedy, Mariapia Degli-Esposti, Geoff R. Hill, Siok-Keen Tey
Publikováno v:
Blood. 138:648-648
Background: Interleukin-6 (IL-6) promotes the differentiation of pathogenic T cells and represents a dominant pathway of cytokine-dysregulation and graft-versus-host disease (GVHD). Cytomegalovirus (CMV) reactivation is a common and life-threatening
Autor:
Simone A. Minnie, Christine R Schmidt, Albert C. Yeh, Julie Boiko, Motoko Koyama, Phil Bradley, Geoff R. Hill, Ethan Nelson, Gabriela Campoy, Sam Legg, Kathleen S. Ensbey
Publikováno v:
Blood. 138:646-646
Background: The immunologic basis of acute GVHD fundamentally involves alloreactive donor T cells that recognize foreign major histocompatibility complex (MHC)-peptide structures derived from both major and minor antigen mismatches with the host. Wit
Autor:
Amanda C Stanley, Fabian de Labastida Rivera, Ashraful Haque, Meru Sheel, Yonghong Zhou, Fiona H Amante, Patrick T Bunn, Louise M Randall, Klaus Pfeffer, Stefanie Scheu, Michael J Hickey, Bernadette M Saunders, Carl Ware, Geoff R Hill, Koji Tamada, Paul M Kaye, Christian R Engwerda
Publikováno v:
PLoS Pathogens, Vol 7, Iss 10, p e1002279 (2011)
LIGHT (TNFSF14) is a member of the TNF superfamily involved in inflammation and defence against infection. LIGHT signals via two cell-bound receptors; herpes virus entry mediator (HVEM) and lymphotoxin-beta receptor (LTβR). We found that LIGHT is cr
Externí odkaz:
https://doaj.org/article/5ef640afe72a44c3a61d67b9da4bb5dc
VCAM-1 and VLA-4 modulate dendritic cell IL-12p40 production in experimental visceral leishmaniasis.
Autor:
Amanda C Stanley, Jane E Dalton, Susanna H Rossotti, Kelli P MacDonald, Yonghong Zhou, Fabian Rivera, Wayne A Schroder, Asher Maroof, Geoff R Hill, Paul M Kaye, Christian R Engwerda
Publikováno v:
PLoS Pathogens, Vol 4, Iss 9, p e1000158 (2008)
Vascular cell adhesion molecule-1 (VCAM-1) interacts with its major ligand very late antigen-4 (VLA-4) to mediate cell adhesion and transendothelial migration of leukocytes. We report an important role for VCAM-1/VLA-4 interactions in the generation
Externí odkaz:
https://doaj.org/article/b2afe5d6ed194f6fba89355169e91596
Autor:
Amanda C Stanley, Yonghong Zhou, Fiona H Amante, Louise M Randall, Ashraful Haque, Daniel G Pellicci, Geoff R Hill, Mark J Smyth, Dale I Godfrey, Christian R Engwerda
Publikováno v:
PLoS Pathogens, Vol 4, Iss 2, p e1000028 (2008)
We report that natural killer T (NKT) cells play only a minor physiological role in protection from Leishmania donovani infection in C57BL/6 mice. Furthermore, attempts at therapeutic activation of invariant NKT (iNKT) cells with alpha-galactosylcera
Externí odkaz:
https://doaj.org/article/e0c2b08e0f7f41aa8e2178719d7a3681
Autor:
Michael L. Meyers, Stephanie J. Lee, Christine Quaranto, Mukta Arora, Madan Jagasia, Antonio Di Stasi, Bruce R. Blazar, Peter Ordentlich, Serap Sankoh, Aaron Schmitt, Geoff R. Hill, Daniel J. Weisdorf, Mohammad Abu Zaid
Publikováno v:
Blood. 136:1-2
Background: Chronic graft versus host disease (cGVHD) is a major cause of morbidity and late non-relapse mortality after allogeneic hematopoietic cell transplantation and is commonly associated with prolonged immune suppression. Patients (pts) with i
Autor:
Madan Jagasia, Tae Kon Kim, Jonathan M. Irish, Kate Chilson, Albert C. Yeh, Lynn Onstad, Ping Zhang, Sierra Barone, Geoff R. Hill, Anupama Reddy, Kimberly B. Dahlman, Stephanie J. Lee
Publikováno v:
Blood. 136:15-16
Background: Cytomegalovirus (CMV) serostatus is associated with transplant related mortality, relapse and survival following allogeneic stem cell transplant (SCT). Prior studies have demonstrated that CMV seronegative recipients (R-) receiving a CMV
Autor:
A. Ekwe, R Western, Raymond Au, M. Tan, M. Fuery, A. Henderson, A. Saldan, Geoff R. Hill, P. Zhang, Kari Mudie, Cheryl Hutchins, B. McEnroe, A. Henden, Siok-Keen Tey, Glen A Kennedy
Publikováno v:
Cytotherapy. 23:S196