Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Geoff P. O'Donoghue"'
Membrane Association Transforms an Inert Anti-TCRβ Fab’ Ligand into a Potent T Cell Receptor Agonist
Autor:
Nicole C. Fay, Jenny J. Lin, Michael P. Coyle, Kiera B. Wilhelm, Katherine N. Alfieri, Shalini T. Low-Nam, Jay T. Groves, Geoff P. O’Donoghue
Publikováno v:
Biophysical Journal. 118:2879-2893
The natural peptide-major histocompatibility complex (pMHC) ligand for T cell receptors (TCRs) is inactive from solution yet capable of activating T cells at single-molecule levels when membrane-associated. This distinctive feature stems from the mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07a63ff2f2bdcb881d31b44d6af2cf18
https://doi.org/10.1016/j.bpj.2020.04.018
https://doi.org/10.1016/j.bpj.2020.04.018
Autor:
Kyle G. Daniels, Geoff P. O’Donoghue, Warren Anderson, David J. Rawlings, Lukasz J. Bugaj, Wendell A. Lim
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Immune cells in the body encounter stimuli in complex temporal patterns, but our understanding of how the timing of stimulation determines immune responses is incomplete. We engineered T cells obtained from healthy human donors to respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86295ebbdbc9b316f4ca73fb724b9962
https://doi.org/10.1073/pnas.2019285118
https://doi.org/10.1073/pnas.2019285118
Publikováno v:
eLife, Vol 2 (2013)
T cells discriminate between self and foreign antigenic peptides, displayed on antigen presenting cell surfaces, via the TCR. While the molecular interactions between TCR and its ligands are well characterized in vitro, quantitative measurements of t
Externí odkaz:
https://doaj.org/article/8c0ff3c12269470290cd9d2c204f613a
Publikováno v:
The Journal of Cell Biology
The Journal of cell biology, vol 216, iss 1
The Journal of cell biology, vol 216, iss 1
In this Viewpoint article, Wendell A. Lim and colleagues examine the ways by which optogenetic tools and techniques are being used to query cellular signaling and function.
Optogenetics promises to deepen our understanding of how cells perceive
Optogenetics promises to deepen our understanding of how cells perceive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0e59c6e471e88f48d72f10f4e55f598
https://doi.org/10.1083/jcb.201612094
https://doi.org/10.1083/jcb.201612094
Autor:
Kiera B. Wilhelm, Shalini T. Low-Nam, Jenny J. Lin, Michael P. Coyle, Geoff P. O’Donoghue, Jay T. Groves
Publikováno v:
Biophysical Journal. 116:530a-531a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92177785986be4aff19809233e6c8ecd
https://doi.org/10.1016/j.bpj.2018.11.2857
https://doi.org/10.1016/j.bpj.2018.11.2857
Autor:
Nicole C. Fay, Shalini T. Low-Nam, Geoff P. O’Donoghue, Rafal M. Pielak, Jenny J. Lin, Jay T. Groves, Katherine N. Alfieri
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 114, iss 46
Proceedings of the National Academy of Sciences of the United States of America, vol 114, iss 46
Significance Antigen discrimination by T cells is based on subtle differences in binding of the T cell receptor (TCR) for its peptide major histocompatibility complex (pMHC) ligand. While such binding characteristics are readily mapped with great pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e663e557ce350908ed09021d4e7e129
https://pubmed.ncbi.nlm.nih.gov/29087297
https://pubmed.ncbi.nlm.nih.gov/29087297
Autor:
Geoff P. O’Donoghue, Yan Yu, Niña G. Caculitan, Eulanca Y. Liu, Nicole C. Fay, Hiroyuki Kai, Theobald Lohmüller, Jay T. Groves
Publikováno v:
Nano Letters
Here we introduce a form of chromatography that can be imposed on the membrane of a living cell. A cell–cell signaling interaction is reconstituted in a hybrid live cell-supported membrane junction. The chromatographic material consists of a hexago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::147426b33a5c9684ef78ebeec47db4c1
https://doi.org/10.1021/nl404514e
https://doi.org/10.1021/nl404514e
Publikováno v:
Journal of the American Chemical Society
The galectin family of glycan-binding proteins is thought to mediate many cellular processes by oligomerizing cell surface glycoproteins and glycolipids into higher-order aggregates. This hypothesis reflects the known oligomeric states of the galecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::263066e26afbe3dd3ba0ff3975a4ff2b
https://doi.org/10.1021/ja301694s
https://doi.org/10.1021/ja301694s
Autor:
Geoff P. O’Donoghue, Michael P. Coyle, Sara B. Triffo, Qian Xu, Jay T. Groves, Theobald Lohmüller
Publikováno v:
Nano Letters
We present a supported membrane platform consisting of a fluid lipid bilayer membrane embedded with a fixed array of gold nanoparticles. The system is realized by preforming a hexagonal array of gold nanoparticles (∼5–7 nm) with controlled spacin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9617f65c162655a5cb72ab7d13db4a1
https://doi.org/10.1021/nl202847t
https://doi.org/10.1021/nl202847t
Publikováno v:
Chemical Physics Letters. 417:159-163
We demonstrate that the gauche conformation of 1H-nonafluorobutane contains a blue-shifting intramolecular hydrogen bond by recording its 5th overtone spectrum with cavity ringdown spectroscopy and performing electronic structure calculations. The ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45d856c3e5a3fdf520f6a16862dffb9a
https://doi.org/10.1016/j.cplett.2005.09.124
https://doi.org/10.1016/j.cplett.2005.09.124