Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Geoff P. Symonds"'
Autor:
Anupriya Aggarwal, Alberto Ospina Stella, Gregory Walker, Anouschka Akerman, Camille Esneau, Vanessa Milogiannakis, Deborah L. Burnett, Samantha McAllery, Mariana Ruiz Silva, Yonghui Lu, Charles S. P. Foster, Fabienne Brilot, Aleha Pillay, Sabastiaan Van Hal, Vennila Mathivanan, Christina Fichter, Andrea Kindinger, Alexandra Carey Hoppe, Mee Ling Munier, Supavadee Amatayakul-Chantler, Nathan Roth, Germano Coppola, Geoff P. Symonds, Peter Schofield, Jennifer Jackson, Helen Lenthall, Jake Y. Henry, Ohan Mazigi, Hans-Martin Jäck, Miles P. Davenport, David R. Darley, Gail V. Matthews, David S. Khoury, Deborah Cromer, Christopher C. Goodnow, Daniel Christ, Roselle Robosa, Damien J. Starck, Nathan W. Bartlett, William D. Rawlinson, Anthony D. Kelleher, Stuart G. Turville
Publikováno v:
Nature Microbiology. 7:896-908
Genetically distinct variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged since the start of the COVID-19 pandemic. Over this period, we developed a rapid platform (R-20) for viral isolation and characterization using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e407f00678907e50f2e6363202ff6c
https://doi.org/10.1038/s41564-022-01135-7
https://doi.org/10.1038/s41564-022-01135-7
Autor:
Bryan P. Burke, Maureen P. Boyd, Helen Impey, Louis R. Breton, Jeffrey S. Bartlett, Geoff P. Symonds, Gero Hütter
Publikováno v:
Viruses, Vol 6, Iss 1, Pp 54-68 (2013)
Human immunodeficiency virus type 1 (HIV-1) infection of target cells requires CD4 and a co-receptor, predominantly the chemokine receptor CCR5. CCR5-delta32 homozygosity results in a truncated protein providing natural protection against HIV infecti
Externí odkaz:
https://doaj.org/article/9725622af370479ebed01723474e9bcd
Autor:
Christopher W. Peterson, Kevin G. Haworth, Bryan P. Burke, Patricia Polacino, Krystin K. Norman, Jennifer E. Adair, Shiu-Lok Hu, Jeffrey S. Bartlett, Geoff P. Symonds, Hans-Peter Kiem
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
We have focused on gene therapy approaches to induce functional cure/remission of HIV-1 infection. Here, we evaluated the safety and efficacy of the clinical grade anti-HIV lentiviral vector, Cal-1, in pigtailed macaques (Macaca nemestrina). Cal-1 an
Externí odkaz:
https://doaj.org/article/affecbdec56d44f99d6c3d7e96bb57ff
Autor:
Samantha A McAllery, Chantelle L Ahlenstiel, Kazuo Suzuki, Geoff P Symonds, Anthony D Kelleher, Stuart G Turville
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
While current antiretroviral therapy has significantly improved, challenges still remain in life-long targeting of HIV-1 reservoirs. Lentiviral gene therapy has the potential to deliver protective genes into the HIV-1 reservoir. However, inefficient
Externí odkaz:
https://doaj.org/article/13bb28f649e7422586405c6b47543506
Publikováno v:
Frontiers in Immunology, Vol 6 (2015)
The current treatment strategy for HIV-1 involves prolonged and intensive combined antiretroviral therapy (cART), which successfully suppresses plasma viremia. It has transformed HIV-1 infection into a chronic disease. However, despite the success of
Externí odkaz:
https://doaj.org/article/a74f1a141c114839bafa284bcbd3f4cf
Autor:
Bryan P Burke, Bernard R Levin, Jane Zhang, Anna Sahakyan, Joshua Boyer, Maria V Carroll, Joanna Camba Colón, Naomi Keech, Valerie Rezek, Gregory Bristol, Erica Eggers, Ruth Cortado, Maureen P Boyd, Helen Impey, Saki Shimizu, Emily L Lowe, Gene-Errol E Ringpis, Sohn G Kim, Dimitrios N Vatakis, Louis R Breton, Jeffrey S Bartlett, Irvin S Y Chen, Scott G Kitchen, Dong Sung An, Geoff P Symonds
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 4, Iss C (2015)
We described earlier a dual-combination anti-HIV type 1 (HIV-1) lentiviral vector (LVsh5/C46) that downregulates CCR5 expression of transduced cells via RNAi and inhibits HIV-1 fusion via cell surface expression of cell membrane-anchored C46 antivira
Externí odkaz:
https://doaj.org/article/3e5b33d836f143b2a0a873b4e9851286
Autor:
Orit Wolstein, Maureen Boyd, Michelle Millington, Helen Impey, Joshua Boyer, Annett Howe, Frederic Delebecque, Kenneth Cornetta, Michael Rothe, Christopher Baum, Tamara Nicolson, Rachel Koldej, Jane Zhang, Naomi Keech, Joanna Camba Colón, Louis Breton, Jeffrey Bartlett, Dong Sung An, Irvin SY Chen, Bryan Burke, Geoff P Symonds
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)
Gene transfer has therapeutic potential for treating HIV-1 infection by generating cells that are resistant to the virus. We have engineered a novel self-inactivating lentiviral vector, LVsh5/C46, using two viral-entry inhibitors to block early steps
Externí odkaz:
https://doaj.org/article/0729ecc492d941b88e3b1faccdaf1b47
Autor:
Gene-Errol E Ringpis, Saki Shimizu, Hubert Arokium, Joanna Camba-Colón, Maria V Carroll, Ruth Cortado, Yiming Xie, Patrick Y Kim, Anna Sahakyan, Emily L Lowe, Munetoshi Narukawa, Fadi N Kandarian, Bryan P Burke, Geoff P Symonds, Dong Sung An, Irvin S Y Chen, Masakazu Kamata
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e53492 (2012)
Down-regulation of the HIV-1 coreceptor CCR5 holds significant potential for long-term protection against HIV-1 in patients. Using the humanized bone marrow/liver/thymus (hu-BLT) mouse model which allows investigation of human hematopoietic stem/prog
Externí odkaz:
https://doaj.org/article/2b0ee1ff496b470290d5a8ee5f6b119e
Publikováno v:
Stem Cells International, Vol 2011 (2011)
Gene therapy for individuals infected with HIV has the potential to provide a once-only treatment that will act to reduce viral load, preserve the immune system, and mitigate cumulative toxicities associated with highly active antiretroviral therapy
Externí odkaz:
https://doaj.org/article/eaec1152634542a8af127427e692e94d
Autor:
Geoff P Symonds
Publikováno v:
Frontiers in Bioscience. 4:d497-505
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cd909ff79f87f8fbb1065fff6d4f4ea
https://doi.org/10.2741/a444
https://doi.org/10.2741/a444