Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Geoff J. M. Parker"'
Autor:
Yolanda Ohene, William J. Harris, Elizabeth Powell, Nina W. Wycech, Katherine F. Smethers, Samo Lasič, Kieron South, Graham Coutts, Andrew Sharp, Catherine B. Lawrence, Hervé Boutin, Geoff J. M. Parker, Laura M. Parkes, Ben R. Dickie
Publikováno v:
Fluids and Barriers of the CNS, Vol 20, Iss 1, Pp 1-18 (2023)
Abstract Blood–brain barrier (BBB) dysfunction occurs in many brain diseases, and there is increasing evidence to suggest that it is an early process in dementia which may be exacerbated by peripheral infection. Filter-exchange imaging (FEXI) is an
Externí odkaz:
https://doaj.org/article/993f91b80b9647f1af20428f0e2b0cb2
Autor:
Reem D. Mahmood, Danielle Shaw, Tine Descamps, Cong Zhou, Robert D. Morgan, Saifee Mullamitha, Mark Saunders, Nerissa Mescallado, Alison Backen, Karen Morris, Ross A. Little, Susan Cheung, Yvonne Watson, James P. B. O’Connor, Alan Jackson, Geoff J. M. Parker, Caroline Dive, Gordon C. Jayson
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-8 (2021)
Abstract Background Patients with metastatic colorectal cancer are treated with cytotoxic chemotherapy supplemented by molecularly targeted therapies. There is a critical need to define biomarkers that can optimise the use of these therapies to maxim
Externí odkaz:
https://doaj.org/article/357e10ddf5c4403488351151c9365ef5
Autor:
Sarah Al-Bachari, Josephine H. Naish, Geoff J. M. Parker, Hedley C. A. Emsley, Laura M. Parkes
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
BackgroundBlood–brain barrier (BBB) disruption has been noted in animal models of Parkinson’s disease (PD) and forms the basis of the vascular hypothesis of neurodegeneration, yet clinical studies are lacking.ObjectiveTo determine alterations in
Externí odkaz:
https://doaj.org/article/ae9cd6f3059a4578beb156bf53a538ec
Autor:
Gordon C. Jayson, Cong Zhou, Alison Backen, Laura Horsley, Kalena Marti-Marti, Danielle Shaw, Nerissa Mescallado, Andrew Clamp, Mark P. Saunders, Juan W. Valle, Saifee Mullamitha, Mike Braun, Jurjees Hasan, Delyth McEntee, Kathryn Simpson, Ross A. Little, Yvonne Watson, Susan Cheung, Caleb Roberts, Linda Ashcroft, Prakash Manoharan, Stefan J. Scherer, Olivia del Puerto, Alan Jackson, James P. B. O’Connor, Geoff J. M. Parker, Caroline Dive
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Identification of response biomarkers is a key step towards the development of personalised care. Here, Jayson et al. identify plasma Tie2 as a biomarker for the response of the tumor vasculature to anti-angiogenics in patients with metastatic colore
Externí odkaz:
https://doaj.org/article/51bffec067d642f8a6e2d9a8af7b2752
Autor:
Irvin Teh, David Shelley, Jordan H. Boyle, Fenglei Zhou, Ana‐Maria Poenar, Noor Sharrack, Richard J. Foster, Nadira Y. Yuldasheva, Geoff J. M. Parker, Erica Dall'Armellina, Sven Plein, Jürgen E. Schneider, Filip Szczepankiewicz
Publikováno v:
Magnetic Resonance in Medicine, 90(1)
Purpose: Tensor-valued diffusion encoding can probe more specific features of tissue microstructure than what is available by conventional diffusion weighting. In this work, we investigate the technical feasibility of tensor-valued diffusion encoding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d49f76d4c53e6fe75a3f32cb0effdacf
https://doi.org/10.1002/mrm.29637
https://doi.org/10.1002/mrm.29637
Autor:
Elizabeth Powell, Yolanda Ohene, Marco Battiston, Ben R. Dickie, Laura M. Parkes, Geoff J. M. Parker
Publikováno v:
Powell, E, Ohene, Y, Battiston, M, Dickie, B R, Parkes, L M & Parker, G J M 2023, ' Blood-brain barrier water exchange measurements using FEXI : Impact of modeling paradigm and relaxation time effects ', Magnetic Resonance in Medicine, vol. 90, no. 1, pp. 34-50 . https://doi.org/10.1002/mrm.29616
Purpose: To evaluate potential modeling paradigms and the impact of relaxation time effects on human blood-brain barrier (BBB) water exchange measurements using FEXI (BBB-FEXI), and to quantify the accuracy, precision, and repeatability of BBB-FEXI e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec3006568994026de6a544ef07929795
http://www.scopus.com/inward/record.url?scp=85150489515&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85150489515&partnerID=8YFLogxK
Autor:
Chunyan Hu, Matthew Grech‐Sollars, Ben Statton, Zhanxiong Li, Fei Gao, Gareth R. Williams, Geoff J. M. Parker, Feng‐Lei Zhou
Publikováno v:
Polymers for Advanced Technologies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b43ebba9d44b315bb4fcfb0a2a74a074
https://doi.org/10.1002/pat.6073
https://doi.org/10.1002/pat.6073
A technique for quantifying regional blood-brain barrier (BBB) water exchange rates using contrast-enhanced arterial spin labelling (CE-ASL) is presented and evaluated in simulations and in vivo. The two-compartment ASL model describes the water exch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a50b5292e0f5538538c0b2896a1ef3f4
https://doi.org/10.1101/2023.02.16.528529
https://doi.org/10.1101/2023.02.16.528529
Autor:
Hamied A. Haroon, Laura M. Parkes, Geoff J M Parker, G Castellazzi, Danka Jandric, Ilona Lipp, Valentina Tomassini, Nils Muhlert, David Rog, David Paling
Publikováno v:
Jandric, D, Lipp, I, Paling, D, Rog, D, Castellazzi, G, Haroon, H, Parkes, L, Parker, G J M, Tomassini, V & Muhlert, N 2021, ' Mechanisms of Network Changes in Cognitive Impairment in Multiple Sclerosis ', Neurology, vol. 97, no. 19, pp. E1886-E1897 . https://doi.org/10.1212/WNL.0000000000012834
Neurology
Neurology
Background and ObjectivesCognitive impairment in multiple sclerosis (MS) is associated with functional connectivity abnormalities. While there have been calls to use functional connectivity measures as biomarkers, there remains to be a full understan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe4d8a64bdeab109e7fe0271cc2fb01
https://doi.org/10.1212/wnl.0000000000012834
https://doi.org/10.1212/wnl.0000000000012834
Autor:
Lauren A. Scott, Geoff J M Parker, Laura M. Parkes, John J. McFadden, Julian C. Matthews, Maelene Lohezic
Publikováno v:
McFadden, J J, Matthews, J, Scott, L A, Parker, G JM, Lohezic, M & Parkes, L 2021, ' Optimization of quantitative susceptibility mapping for regional estimation of oxygen extraction fraction in the brain ', Magnetic Resonance in Medicine, vol. 86, no. 3, pp. 1314-1329 . https://doi.org/10.1002/mrm.28789
PurposeWe sought to determine the degree to which oxygen extraction fraction (OEF) estimated using quantitative susceptibility mapping (QSM) depends on two critical acquisition parameters that have a significant impact on acquisition time: voxel size
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49763a7caad907fd6bc01b804c22ae94
https://doi.org/10.1002/mrm.28789
https://doi.org/10.1002/mrm.28789