Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Geoff Hide"'
Publikováno v:
BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Background Trichomoniasis caused by Trichomonas vaginalis is the most prevalent nonviral sexually transmitted disease in women and has frequently damaged public health. To better use the animal model and take a step forward fully elucidating
Externí odkaz:
https://doaj.org/article/a8382d31266f425cb3b8ce4091fc0c7e
Autor:
Jiang-Mei Gao, Shou-Yue Xia, Geoff Hide, Bi-Hai Li, Yi-Yan Liu, Zhi-Yuan Wei, Xiao-Ji Zhuang, Qing Yan, Yun Wang, Wei Yang, Jian-Huan Chen, Jun-Hua Rao
Publikováno v:
npj Biofilms and Microbiomes, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract The gut microbiota has been demonstrated to play a significant role in the pathogenesis of Parkinson’s disease (PD). However, conflicting findings regarding specific microbial species have been reported, possibly due to confounding factors
Externí odkaz:
https://doaj.org/article/72c8980d626348c390850e3bd99c56d2
Autor:
Siyu Zhao, Yunyi Hu, Bicheng Yang, Lichao Zhang, Meiyining Xu, Kefeng Jiang, Zhun Liu, Mingrou Wu, Yun Huang, Peipei Li, Si-Jia Liang, Xi Sun, Geoff Hide, Zhao-Rong Lun, Zhongdao Wu, Jia Shen
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The anti-foreign tissue (transplant rejection) response, mediated by the immune system, has been the biggest obstacle to successful organ transplantation. There are still many enigmas regarding this process and some aspects of the underlying
Externí odkaz:
https://doaj.org/article/5cb2e6c9ee544175ba96af93dd6f01e6
Autor:
Hui Dong, Jiong Yang, Kai He, Wen-Bin Zheng, De-Hua Lai, Jing Liu, Hui-Yong Ding, Rui-Bin Wu, Kevin M Brown, Geoff Hide, Zhao-Rong Lun, Xing-Quan Zhu, Shaojun Long
Publikováno v:
eLife, Vol 12 (2024)
The apicoplast is a four-membrane plastid found in the apicomplexans, which harbors biosynthesis and organelle housekeeping activities in the matrix. However, the mechanism driving the flux of metabolites, in and out, remains unknown. Here, we used T
Externí odkaz:
https://doaj.org/article/8397a5d62a4d4a6b99f4c420622439eb
Autor:
Jia Shen, Siyu Zhao, Mei Peng, Yanguo Li, Lichao Zhang, Xiaoping Li, Yunyi Hu, Mingrou Wu, Suoyu Xiang, Xiaoying Wu, Jiahua Liu, Beibei Zhang, Zebin Chen, Datao Lin, Huanyao Liu, Wenyan Tang, Jun Chen, Xi Sun, Qi Liao, Geoff Hide, Zhijun Zhou, Zhao-Rong Lun, Zhongdao Wu
Publikováno v:
Cell Discovery, Vol 9, Iss 1, Pp 1-21 (2023)
Abstract Schistosoma parasites, causing schistosomiasis, exhibit typical host specificity in host preference. Many mammals, including humans, are susceptible to infection, while the widely distributed rodent, Microtus fortis, exhibits natural anti-sc
Externí odkaz:
https://doaj.org/article/16c888a22e6441728ae6f69087dc4657
Autor:
Wenyan Wan, Hui Dong, De-Hua Lai, Jiong Yang, Kai He, Xiaoyan Tang, Qun Liu, Geoff Hide, Xing-Quan Zhu, L. David Sibley, Zhao-Rong Lun, Shaojun Long
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Toxoplasma gondii acquires host cytosolic materials, yet the mechanism remains unknown. Wan et al. reveal the micropore as an essential organelle at the plasma membrane for endocytosis of host cytosolic proteins and biotin, and Golgi ceramide.
Externí odkaz:
https://doaj.org/article/c20394fc9378424aad96f749b94f2e74
Autor:
Qiang-Qiang Wang, Ming Sun, Tao Tang, De-Hua Lai, Jing Liu, Sanjay Maity, Kai He, Xi-Ting Wu, Jiong Yang, Yue-Bao Li, Xiao-Yan Tang, Hui-Yong Ding, Geoff Hide, Mark Distefano, Zhao-Rong Lun, Xing-Quan Zhu, Shaojun Long
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT In the apicomplexans, endocytosed cargos (e.g., hemoglobin) are trafficked to a specialized organelle for digestion. This follows a unique endocytotic process at the micropore/cytostome in these parasites. However, the mechanism underlying e
Externí odkaz:
https://doaj.org/article/402a8b5207a94fc08108a12515f8837f
Autor:
Iben Lyskjær, Christopher Davies, Anna‐Christina Strobl, Joanna Hindley, Steven James, Radhesh K. Lalam, William Cross, Geoff Hide, Kenneth S. Rankin, Lee Jeys, Roberto Tirabosco, Jonathan Stevenson, Genomics England Research Consortium, Paul O’Donnell, Paul Cool, Adrienne M. Flanagan
Publikováno v:
Molecular Oncology, Vol 15, Iss 12, Pp 3679-3690 (2021)
Chondrosarcoma (CS) is a rare tumour type and the most common primary malignant bone cancer in adults. The prognosis, currently based on tumour grade, imaging and anatomical location, is not reliable, and more objective biomarkers are required. We ai
Externí odkaz:
https://doaj.org/article/06050dfe09da4f93b0994c5d65b4ce29
Autor:
Yan-Zi Wen, Hao-Tian Tang, Xiao-Li Cai, Na Wu, Jia-Zhen Xu, Bi-Xiu Su, Geoff Hide, Zhao-Rong Lun, De-Hua Lai
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
IntroductionTrypanosoma brucei, T. evansi and T. equiperdum are members of the subgenus Trypanozoon and are highly similar morphologically and genetically. The main differences between these three species are their differentiation patterns in the hos
Externí odkaz:
https://doaj.org/article/521ae0c749b8493093200d40ec028945
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 5, p e0010403 (2022)
Humans and a wide range of mammals are generally susceptible to Schistosoma infection, while some rodents such as Rattus rats and Microtus spp are not. We previously demonstrated that inherent high expression levels of nitric oxide (NO), produced by
Externí odkaz:
https://doaj.org/article/02f95f91ae6c4a6a8b192d4f6af7b863