Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Geoff H, Werstuck"'
Autor:
Hargun Kaur, Geoff H. Werstuck, PhD
Publikováno v:
CJC Open, Vol 3, Iss 10, Pp 1238-1248 (2021)
Cardiovascular disease (CVD) is the leading cause of death worldwide. The effects of testosterone, the primary male sex hormone, on cardiovascular risk have been of special interest due to the increased risk of CVD in men. Although it is well establi
Externí odkaz:
https://doaj.org/article/260fcd8ee6104afab1a1a96e60d1fa38
Autor:
Emily A. Day, Rebecca J. Ford, Brennan K. Smith, Vanessa P. Houde, Stephanie Stypa, Sonia Rehal, Sarka Lhotak, Bruce E. Kemp, Bernardo L. Trigatti, Geoff H. Werstuck, Richard C. Austin, Morgan D. Fullerton, Gregory R. Steinberg
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101321- (2021)
Objective: Salsalate is a prodrug of salicylate that lowers blood glucose in people with type 2 diabetes. AMP-activated protein kinase (AMPK) is an αβγ heterotrimer which inhibits macrophage inflammation and the synthesis of fatty acids and choles
Externí odkaz:
https://doaj.org/article/ac41af7c053648d78768cda15dc2b35a
Autor:
Lauren Mastrogiacomo, Robert Ballagh, Daniel E. Venegas-Pino, Hargun Kaur, Peter Shi, Geoff H. Werstuck
Publikováno v:
The American Journal of Pathology. 193:121-133
It is well established that patients with diabetes have an increased risk of developing atherosclerotic cardiovascular disease. The earliest detectable sign of atherosclerosis initiation is endothelial cell activation. Activated endothelial cells exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d76692352b6442d85f0f759c8261ca
https://doi.org/10.1016/j.ajpath.2022.09.004
https://doi.org/10.1016/j.ajpath.2022.09.004
Autor:
Geoff H. Werstuck, Hargun Kaur
Publikováno v:
CJC Open, Vol 3, Iss 10, Pp 1238-1248 (2021)
CJC Open
CJC Open
Cardiovascular disease (CVD) is the leading cause of death worldwide. The effects of testosterone, the primary male sex hormone, on cardiovascular risk have been of special interest due to the increased risk of CVD in men. Although it is well establi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61f008a0b65de8d4f0a37bd1292fa572
http://www.sciencedirect.com/science/article/pii/S2589790X21001335
http://www.sciencedirect.com/science/article/pii/S2589790X21001335
Publikováno v:
The American Journal of Pathology. 191:1490-1498
Insulin resistance results when peripheral tissues, including adipose, skeletal muscle, and liver, do not respond appropriately to insulin, causing the ineffective uptake of glucose. This represents a risk factor for the development of type 2 diabete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b13258404d683c1eef97db701676b7a
https://doi.org/10.1016/j.ajpath.2021.05.011
https://doi.org/10.1016/j.ajpath.2021.05.011
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 16; Pages: 9293
Recent evidence from our laboratory suggests that impeding ER stress–GSK3α/β signaling attenuates the progression and development of atherosclerosis in mouse model systems. The objective of this study was to determine if the tissue-specific genet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf8d9724acb464d9a0975794ed860a8
https://pubmed.ncbi.nlm.nih.gov/36012557
https://pubmed.ncbi.nlm.nih.gov/36012557
Autor:
Monica De Paoli, Dempsey W. Wood, Mary K. Bohn, Arjun K. Pandey, Dana K. Borowitz, Susanna Fang, Zinal Patel, Daniel E. Venegas-Pino, Yuanyuan Shi, Geoff H. Werstuck
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 323(3)
This study examines the effect(s) of estrogen on β cell and cardiometabolic health/function in a novel mouse model of hyperglycemia-induced atherosclerosis ( ApoE−/−: Ins2+/Akita). Using a combination of estrogen deprivation (ovariectomy) and su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9854d3d79644e890131f4cca0f97ed1
https://pubmed.ncbi.nlm.nih.gov/35830687
https://pubmed.ncbi.nlm.nih.gov/35830687
Autor:
Cameron S. McAlpine, Geoff H. Werstuck
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 11, Pp 2320-2333 (2014)
Evidence suggests a causative role for endoplasmic reticulum (ER) stress in the development of atherosclerosis. This study investigated the potential role of glycogen synthase kinase (GSK)-3α/β in proatherogenic ER stress signaling. Thp1-derived ma
Externí odkaz:
https://doaj.org/article/f6c948ec136e436c937bc60238258c9e
Autor:
Magda Naeim, Geoff H. Werstuck, Jehonathan H. Pinthus, Shawn Dason, Sarah N. Hopmans, Sadiya Yousef, Wilhelmina C.M. Duivenvoorden
Publikováno v:
Prostate Cancer and Prostatic Diseases. 24:389-397
Unlike in other mouse models of atherogenesis, it has recently been suggested that orchiectomy plays a role in attenuating atherosclerosis and inhibiting the progression of cardiovascular disease in the ApoE−/−:Ins2+/Akita mouse model of hypergly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b25c25ef21475ca367268eae4fd9408d
https://doi.org/10.1038/s41391-020-00288-y
https://doi.org/10.1038/s41391-020-00288-y
Autor:
Richard C. Austin, Bruce E. Kemp, Stephanie A. Stypa, Gregory R. Steinberg, Brennan K. Smith, Bernardo L. Trigatti, Sonia Rehal, Emily A. Day, Geoff H. Werstuck, Rebecca J. Ford, Vanessa P. Houde, Morgan D. Fullerton, Šárka Lhoták
Publikováno v:
Molecular Metabolism, Vol 53, Iss, Pp 101321-(2021)
Molecular Metabolism
Molecular Metabolism
Objective Salsalate is a prodrug of salicylate that lowers blood glucose in people with type 2 diabetes. AMP-activated protein kinase (AMPK) is an αβγ heterotrimer which inhibits macrophage inflammation and the synthesis of fatty acids and cholest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d260f1ca51f9a668e3df9cc47bb8ecfd
http://www.sciencedirect.com/science/article/pii/S221287782100168X
http://www.sciencedirect.com/science/article/pii/S221287782100168X