Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Geoff Connolly"'
Publikováno v:
PLoS ONE, Vol 3, Iss 9, p e3254 (2008)
Previous studies have indicated that Epstein-Barr virus (EBV) can modulate the Wnt pathway in virus-infected cells and this effect is mediated by EBV-encoded oncogene latent membrane protein 1 (LMP1). Here we have reassessed the role of LMP1 in regul
Externí odkaz:
https://doaj.org/article/0584fcbf927441c3b92e408c20bfffd8
Autor:
Geoff Connolly, Michael P. Devoy, David C. Tscharke, Natasha Webb, Michael Rist, Corey Smith, Leanne Cooper, Rajiv Khanna, Judy Tellam, Tony Vuocolo
Publikováno v:
Proceedings of the National Academy of Sciences. 105:9319-9324
Many viruses avoid immune surveillance during latent infection through reduction in the synthesis of virally encoded proteins. Although antigen presentation critically depends on the level of viral protein synthesis, the precise mechanism used to reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b2f187a381b5e41cc5a8a31dd4c2fca
https://doi.org/10.1073/pnas.0801968105
https://doi.org/10.1073/pnas.0801968105
Autor:
Natasha Webb, Fred Wang, Michael Rist, Geoff Connolly, Chrysa Fazou, Judy Tellam, Rajiv Khanna
Publikováno v:
European Journal of Immunology. 37:328-337
Lymphocryptoviruses (LCV) that infect humans and Old World primates display a significant degree of genetic identity. These viruses use B lymphocytes as primary host cells to establish a long-term latent infection and express highly homologous latent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a32b16a3859c71dab80501decde9542
https://doi.org/10.1002/eji.200636153
https://doi.org/10.1002/eji.200636153
Autor:
Mark H. Fogg, Judy Tellam, Michael Rist, David C. Tscharke, Lea Heslop, Fred Wang, Geoff Connolly, Rajiv Khanna, Natasha Webb
Publikováno v:
The Journal of Experimental Medicine
A significant proportion of endogenously processed CD8(+) T cell epitopes are derived from newly synthesized proteins and rapidly degrading polypeptides (RDPs). It has been hypothesized that the generation of rapidly degrading polypeptides and CD8(+)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0fc11aea006af5422e64c950c403a1c
http://europepmc.org/articles/PMC2137904
http://europepmc.org/articles/PMC2137904
Autor:
Leanne Cooper, Jaikumar Duraiswamy, Rajiv Khanna, Mandvi Bharadwaj, Geoff Connolly, Scott Thomson, Patricia Yotnda, Judy Tellam, Denis J. Moss
Publikováno v:
Cancer Research. 64:1483-1489
The EBV-encoded latent membrane proteins (LMP1 and LMP2), which are expressed in various EBV-associated malignancies have been proposed as a potential target for CTL-based therapy. However, the precursor frequency for LMP-specific CTL is generally lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e4b15cdc75f408b2f495e3eaa74609
https://doi.org/10.1158/0008-5472.can-03-2196
https://doi.org/10.1158/0008-5472.can-03-2196
Autor:
Katherine J. Green, Wendy J. van Zuylen, Geoff Connolly, Scott R. Burrows, John J. Miles, Judy Tellam
Publikováno v:
European journal of immunology. 34(9)
The BZLF1 antigen of Epstein-Barr virus includes three overlapping sequences of different lengths that conform to the binding motif of human leukocyte antigen (HLA) B*3501. These 9-mer (56LPQGQLTAY64), 11-mer (54EPLPQGQLTAY64), and 13-mer (52LPEPLPQG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ddb9497fc21131d3b4efbf8ba4d52e4
https://pubmed.ncbi.nlm.nih.gov/15307183
https://pubmed.ncbi.nlm.nih.gov/15307183
Autor:
Scott R. Burrows, Geoff Connolly, Katherine J. Green, Rajiv Khanna, Denis J. Moss, Judy Tellam, John J. Miles
Publikováno v:
The Journal of Experimental Medicine
Epstein-Barr virus (EBV)–encoded nuclear antigen (EBNA)1 is thought to escape cytotoxic T lymphocyte (CTL) recognition through either self-inhibition of synthesis or by blockade of proteasomal degradation by the glycine-alanine repeat (GAr) domain.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b8019af6f7b8002ee2382f5537120e8
https://pubmed.ncbi.nlm.nih.gov/15148340
https://pubmed.ncbi.nlm.nih.gov/15148340
Autor:
Geoff Connolly, Scott R. Burrows, Jacqueline M. Burrows, Denis J. Moss, Judy Tellam, Megan Woolfit, Leanne Cooper, Sofia Mubarika Haryana, Lindell Bromham, Gwenael Piganeau, Mun H. Ng, Natasha Webb, John M. Nicholls, L M Poulsen, Rajiv Khanna
The geographically constrained distribution of Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) in southeast Asian populations suggests that both viral and host genetics may influence disease risk. Although susceptibility loci have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d8bed5c9469125278fa6b8bdee010a
http://hdl.handle.net/10722/49423
http://hdl.handle.net/10722/49423
Publikováno v:
Blood. 102(13)
The ability of viral or mutated cellular oncogenes to initiate neoplastic events and their poor immunogenicity have considerably undermined their potential use as immunotherapeutic tools for the treatment of human cancers. Using an Epstein-Barr virus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db122ff24edf8baee584d98488dc1244
https://pubmed.ncbi.nlm.nih.gov/12920032
https://pubmed.ncbi.nlm.nih.gov/12920032
Therapeutic LMP1 polyepitope vaccine for EBV-associated Hodgkin disease and nasopharyngeal carcinoma
Autor:
Geoff Connolly, Judy Tellam, Mandvi Bharadwaj, Scott Thomson, Leanne Cooper, Rajiv Khanna, Martina Sherritt, Jaikumar Duraiswamy
Publikováno v:
Blood. 101(8)
Development of an epitope-based vaccination strategy designed to enhance Epstein-Barr virus (EBV)-specific CD8(+) cytotoxic T lymphocytes (CTLs) is increasingly being considered as a preferred approach for the treatment of EBV-associated relapsed Hod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e031ce72e6c335667d8bc7370e68b1
https://pubmed.ncbi.nlm.nih.gov/12468425
https://pubmed.ncbi.nlm.nih.gov/12468425