Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Geoff A. Otto"'
Autor:
Philip J. Stephens, Vincent A. Miller, Matthew Hawryluk, Doron Lipson, Roman Yelensky, Sean R. Downing, Kristina Brennan, John A. Curran, Rachel Erlich, Garrett Frampton, Elaine LaBrecque, Geneva Young, Michelle Nahas, Siraj Ali, Gary Palmer, Jie He, Amy Donahue, Geoff A. Otto, Timothy A. Jennings, Christine E. Sheehan, Tipu Nazeer, Rami N. Al-Rohil, Laurie M. Gay, Kai Wang, Jeffrey S. Ross
Purpose: Micropapillary urothelial carcinoma (MPUC) is a rare and aggressive form of bladder cancer. We conducted genomic analyses [next-generation sequencing (NGS)] of MPUC and non-micropapillary urothelial bladder carcinomas (non-MPUC) to character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5ac638c70ef8fdb21102c1e28fcd42
https://doi.org/10.1158/1078-0432.c.6521835.v1
https://doi.org/10.1158/1078-0432.c.6521835.v1
Autor:
Ben H. Park, Vered Stearns, Jane Zorzi, Zhe Zhang, Daniel J. Zabransky, Lauren E. Young, Antonio C. Wolff, Dustin A. VanDenBerg, Philip J. Stephens, Shannon Slater, Jeffrey S. Ross, Gary L. Rosner, Geoff A. Otto, Vincent A. Miller, Doron Lipson, Justin Lee, Josh Lauring, Mark R. Kennedy, Stacie C. Jeter, Christopher D. Gocke, Travis A. Clark, Sarah Croessmann, Rory L. Cochran, Roisin M. Connolly, David Chu, Jennifer Axilbund, Siraj M. Ali, Ashley Cimino-Mathews, Julia A. Beaver, Heather A. Parsons
Purpose: The clinical utility of next-generation sequencing (NGS) in breast cancer has not been demonstrated. We hypothesized that we could perform NGS of a new biopsy from patients with metastatic triple-negative breast cancer (TNBC) in a clinically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ccbc9a10eb6d0761509999c0ea9a4ed
https://doi.org/10.1158/1078-0432.c.6526784.v1
https://doi.org/10.1158/1078-0432.c.6526784.v1
Autor:
Philip J. Stephens, Vincent A. Miller, Matthew Hawryluk, Doron Lipson, Roman Yelensky, Sean R. Downing, Kristina Brennan, John A. Curran, Rachel Erlich, Garrett Frampton, Elaine LaBrecque, Geneva Young, Michelle Nahas, Siraj Ali, Gary Palmer, Jie He, Amy Donahue, Geoff A. Otto, Timothy A. Jennings, Christine E. Sheehan, Tipu Nazeer, Rami N. Al-Rohil, Laurie M. Gay, Kai Wang, Jeffrey S. Ross
PDF file - 65K, Supplementary Figure 1. Tile Plot of Genomic Alterations in 64Cases on Non-micropapillary Urothelial Carcinoma.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e00df7ea2b0d592b6fb6523fdf20db7
https://doi.org/10.1158/1078-0432.22450035.v1
https://doi.org/10.1158/1078-0432.22450035.v1
Autor:
Philip J. Stephens, Vincent A. Miller, Matthew Hawryluk, Doron Lipson, Roman Yelensky, Sean R. Downing, Kristina Brennan, John A. Curran, Rachel Erlich, Garrett Frampton, Elaine LaBrecque, Geneva Young, Michelle Nahas, Siraj Ali, Gary Palmer, Jie He, Amy Donahue, Geoff A. Otto, Timothy A. Jennings, Christine E. Sheehan, Tipu Nazeer, Rami N. Al-Rohil, Laurie M. Gay, Kai Wang, Jeffrey S. Ross
PDF file - 207K, Supplementary Table Genomic Alterations in 64 Cases of Relapsed/Metastatic Non-Micropapillary Urothelial Carcinoma of the Bladder.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::135df7a3e3ba4a86fc6d743aa8f813c0
https://doi.org/10.1158/1078-0432.22450032.v1
https://doi.org/10.1158/1078-0432.22450032.v1
Autor:
Geoff A. Otto, Joseph D. Puglisi
Publikováno v:
Cell. 119(3):369-380
The HCV internal ribosome entry site (IRES) directly regulates the assembly of translation initiation complexes on viral mRNA by a sequential pathway that is distinct from canonical eukaryotic initiation. The HCV IRES can form a binary complex with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90b90a3cd0366a58cf40d8fc58564816
Publikováno v:
Nature Structural & Molecular Biology. 10:1033-1038
Complex RNA structures regulate many biological processes, but are often too large for structure determination by NMR methods. The 5' untranslated region (5' UTR) of the hepatitis C viral (HCV) RNA genome contains an internal ribosome entry site (IRE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7208917ebde71733e16c9ac1e027ce30
https://doi.org/10.1038/nsb1004
https://doi.org/10.1038/nsb1004
Publikováno v:
RNA. 8:913-923
Translation of the hepatitis C virus genomic RNA is mediated by an internal ribosome entry site (IRES). The 330-nt IRES RNA forms a binary complex with the small 40S ribosomal subunit as a first step in translation initiation. Here chemical probing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d8256c81306a15b5c83441de2b75cf
https://doi.org/10.1017/s1355838202022057
https://doi.org/10.1017/s1355838202022057
Publikováno v:
Nature Structural Biology. 7:1105-1110
Translation of the hepatitis C virus (HCV) polyprotein is initiated at an internal ribosome entry site (IRES) element in the 5' untranslated region of HCV RNA. The HCV IRES element interacts directly with the 40S subunit, and biochemical experiments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d28acfc81a8aedfddf9ad89be2a7798
https://doi.org/10.1038/81951
https://doi.org/10.1038/81951
Autor:
Alissa M. Lancaster, Insil Kim, Peter Sarnow, Geoff A. Otto, Peter J. Lukavsky, Joseph D. Puglisi
Publikováno v:
Nucleic acids research. Supplement (2001). (1)
Hepatitis C is a major world health problem, caused Hepatitis C virus (HCV). Therapeutic intervention against HCV has been hindered by a lack of understanding of the fundamental processes in the viral life cycle. HCV uses a novel mechanism of transla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4586b7d6c7bae8f7001a5fbbb2095c0d
https://pubmed.ncbi.nlm.nih.gov/12836365
https://pubmed.ncbi.nlm.nih.gov/12836365
Autor:
Jeffrey R Gardner, Michelle K. Nahas, Jie He, Minal Patel, Kristina M. Knapp, M. Lia Palomba, Roman Yelensky, Amy L Donahue, Geoff A. Otto, Maria Arcila, Ahmet Dogan, Jae H Park, Andrew D. Zelenetz, Doron Lipson, Martin S. Tallman, Ross L. Levine, Philip J. Stephens, Marcel R. M. van den Brink, Vincent A. Miller, Mark L Heaney, Omar Abdel-Wahab
Publikováno v:
Blood. 122:2858-2858
Recent whole-genome sequencing, whole-exome sequencing, and copy number analysis studies in small sets of patients with chronic lymphocytic leukemia (CLL) at presentation versus progression have demonstrated that clonal evolution has clinical and bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3730a764ca987a15127c3ceee58de39
https://doi.org/10.1182/blood.v122.21.2858.2858
https://doi.org/10.1182/blood.v122.21.2858.2858