Toxicity by descent: A comparative approach for chemical hazard assessment

Autor: John K. Colbourne, Joseph R. Shaw, Elena Sostare, Claudia Rivetti, Romain Derelle, Rosemary Barnett, Bruno Campos, Carlie LaLone, Mark R. Viant, Geoff Hodges

Publikováno v: Environmental Advances, Vol 9, Iss , Pp 100287- (2022)

Toxicology is traditionally divided between human and eco-toxicology. In the shared pursuit of environmental health, this separation does not account for discoveries made in the comparative studies of animal genomes. Here, we provide evidence on the

Externí odkaz: https://doaj.org/article/c895c46d8de940a698204276b1472775

Genes‐to‐Pathways Species Conservation Analysis: Enabling the Exploration of Conservation of Biological Pathways and Processes Across Species

Autor: Claudia Rivetti, Jade Houghton, Danilo Basili, Geoff Hodges, Bruno Campos

Publikováno v: Environmental Toxicology and Chemistry. 42:1152-1166

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8a1b9763ced9fedeffd99c722fe32c5
https://doi.org/10.1002/etc.5600

Partitioning into phosphatidylcholine–cholesterol membranes: liposome measurements, coarse-grained simulations, and implications for bioaccumulation

Autor: Thomas D. Potter, Nicola Haywood, Alexandre Teixeira, Geoff Hodges, Elin L. Barrett, Mark A. Miller

Publikováno v: Environmental Science: Processes & Impacts.

Liposome measurements and coarse-grained simulations are used to assess the cholesterol dependence of membrane-water partitioning for small molecules and the implications for bioaccumulation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7eed001949ebf1c97bdfa7029beeeee5
https://doi.org/10.1039/d3em00081h

Improved Algal Toxicity Test System for Robust Omics-Driven Mode-of-Action Discovery in Chlamydomonas reinhardtii

Autor: Stefan Schade, Emma Butler, Steve Gutsell, Geoff Hodges, John K. Colbourne, Mark R. Viant

Publikováno v: Metabolites, Vol 9, Iss 5, p 94 (2019)

Algae are key components of aquatic food chains. Consequently, they are internationally recognised test species for the environmental safety assessment of chemicals. However, existing algal toxicity test guidelines are not yet optimized to discover m

Externí odkaz: https://doaj.org/article/94a469f2df4e422c9a632e377f5c4d2e

Vision of a near future: Bridging the human health–environment divide

Autor: Lina Gunnarsson, Bruno Campos, Paul L. Carmichael, Andrew White, John K. Colbourne, Geoff Hodges, Matthew P. Dent, Cecilie Rendal, Imran Shah, Carl Westmoreland, Paul Jennings, Claudia Rivetti, Steve Gutsell, Sharon J. Scott, Aude Kienzler, Ian Sorrel, Emma Butler, Luigi Margiotta-Casaluci, Fiona Sewell, Joshua A. Harrill, Richard S. Judson, Iris Muller, Stewart F. Owen, Timothy E. H. Allen, James B. Brown, Francesco Falciani, Mark R. Viant, Paul J. Russell

Publikováno v: Toxicology in Vitro, 62:104692, 1-9. Elsevier Limited
Rivetti, C, Allen, T E H, Brown, J B, Butler, E, Carmichael, P L, Colbourne, J K, Dent, M, Falciani, F, Gunnarsson, L, Gutsell, S, Harrill, J A, Hodges, G, Jennings, P, Judson, R, Kienzler, A, Margiotta-Casaluci, L, Muller, I, Owen, S F, Rendal, C, Russell, P J, Scott, S, Sewell, F, Shah, I, Sorrel, I, Viant, M R, Westmoreland, C, White, A & Campos, B 2020, ' Vision of a near future: Bridging the human health–environment divide : Toward an integrated strategy to understand mechanisms across species for chemical safety assessment ', Toxicology in Vitro, vol. 62, 104692, pp. 1-9 . https://doi.org/10.1016/j.tiv.2019.104692

There is a growing recognition that application of mechanistic approaches to understand cross-species shared molecular targets and pathway conservation in the context of hazard characterization, provide significant opportunities in risk assessment (R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4bad4785f71967ae94c513c48dac2fa
https://research.vu.nl/en/publications/e3f48638-347c-4e03-95a4-da43d64ae781