Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Geoff, Hackett"'
Autor:
Adrian Heald, Michael Cook, Leen Antonio, Dirk Vanderschueren, Ahmed Javed, Helene Fachim, Geoff Hackett, Fred Wu, Terence O’Neill
Publikováno v:
The Aging Male, Vol 25, Iss 1, Pp 167-172 (2022)
Introduction The androgen receptor (AR) mediates peripheral effects of testosterone. Evidence suggests that the number of CAG repeats in exon-1 of the AR gene negatively correlates with AR transcriptional activity. The aim of this analysis was to det
Externí odkaz:
https://doaj.org/article/0003060dab5d4c359f68a5ab889b6c6c
Autor:
Jemma Hudson, MSc, Moira Cruickshank, PhD, Richard Quinton, MD, Lorna Aucott, PhD, Magaly Aceves-Martins, PhD, Katie Gillies, PhD, Shalender Bhasin, ProfMB BS, Peter J Snyder, ProfMD, Susan S Ellenberg, ProfPhD, Mathis Grossmann, ProfPhD, Thomas G Travison, PhD, Emily J Gianatti, PhD, Yvonne T van der Schouw, ProfPhD, Marielle H Emmelot-Vonk, ProfPhD, Erik J Giltay, PhD, Geoff Hackett, FRCPI, Sudarshan Ramachandran, PhD, Johan Svartberg, ProfPhD, Kerry L Hildreth, MD, Kristina Groti Antonic, PhD, Gerald B Brock, ProfMD, J Lisa Tenover, ProfMD, Hui Meng Tan, FRCS, Christopher Ho Chee Kong, FRCS, Wei Shen Tan, PhD, Leonard S Marks, ProfMD, Richard J Ross, ProfMD, Robert S Schwartz, ProfMD, Paul Manson, BA Hons, Stephen Roberts, PhD, Marianne Skovsager Andersen, ProfDmSci, Line Velling Magnussen, PhD, Rodolfo Hernández, PhD, Nick Oliver, ProfFRCP, Frederick Wu, ProfMD, Waljit S Dhillo, ProfPhD, Siladitya Bhattacharya, ProfMD, Miriam Brazzelli, PhD, Channa N Jayasena, PhD
Publikováno v:
The Lancet. Healthy Longevity, Vol 3, Iss 6, Pp e381-e393 (2022)
Summary: Background: Testosterone is the standard treatment for male hypogonadism, but there is uncertainty about its cardiovascular safety due to inconsistent findings. We aimed to provide the most extensive individual participant dataset (IPD) of t
Externí odkaz:
https://doaj.org/article/70b4dbf3d7d14292b6edc7c0fd36828c
Autor:
Adrian Heald, Ghasem Yadegarfar, Mark Livingston, Helene Fachim, Ram Prakash Narayanan, Mark Lunt, Kirk Siddals, Gabriela Cortes, Martin Gibson, Rachelle Donn, Simon Anderson, Geoff Hackett, Hugh Jones
Publikováno v:
Artery Research, Vol 25, Iss S1, Pp S178-S179 (2020)
Abstract Background Hypogonadism associates with increased cardiovascular morbidity/mortality in type 2 diabetes mellitus (T2DM) [1]. Increasing CAG repeat number within exon 1 of the androgen receptor gene associates with increased androgen receptor
Externí odkaz:
https://doaj.org/article/d6140b3741864920bbf1eced1d345355
Autor:
Nagaraj S. Malipatil, Ghasem Yadegarfar, Mark Lunt, Brian Keevil, Kirk Siddals, Mark Livingston, Siriol Roberts, Prakash Narayanan, Martin Rutter, J. Martin Gibson, Rachelle Donn, Geoff Hackett, T. Hugh Jones, Adrian Heald
Publikováno v:
Endocrinology, Diabetes & Metabolism, Vol 2, Iss 3, Pp n/a-n/a (2019)
Summary Introduction Hypogonadism is more prevalent in men with type 2 diabetes (T2DM) (25%‐40%) than in men without T2DM. Hypogonadism has been associated with poorer glycaemic outcomes and increased cardiovascular morbidity/mortality. We report a
Externí odkaz:
https://doaj.org/article/0081f6e5b2494e079b256bb12681037a
Autor:
Sudarshan Ramachandran, Carola S. König, Amro Maarouf, Karim Sultan Haider, Farid Saad, Pieter Desnerck, Nathan Lorde, Geoff Hackett, Richard C. Strange, A Haider, Adeeba Ahmed
Publikováno v:
Androgens: Clinical Research and Therapeutics. 2:150-159
Copyright © Richard C. Strange et al., 2021. Objective: Testosterone therapy (TTh) may reduce morbidity/mortality in men with adult-onset testosterone deficiency (TD), though some cardiovascular safety concerns remain. Increased hematocrit (HCT), a
Autor:
Marianne Andersen, Kristina Antonic, Lorna Aucott, Shalender Bhasin, Siladitya Bhattacharya, Miriam Brazzelli, Moira Cruickshank, Waljit Dhillo, Susan Ellenberg, Marielle Emmelot-Vonk, Emily Gianatti, Erik Giltay, Mathis Grossmann, Geoff Hackett, Kerry Hildreth, Jemma Hudson, Leonard Marks, Richard Quinton, Peter Snyder, Johan Svartberg, Hui Tan, Lisa Tenover, Thomas Travison, Frederick Wu, Channa Jayasena
Publikováno v:
Journal of the Endocrine Society. 6:A684-A685
Background The cardiovascular safety of testosterone treatment in low testosterone is widely acknowledged to be unclear. Testosterone increases haematocrit, thereby potentially increasing venous thromboembolism risk. The FDA lists cardiovascular risk
Autor:
Jemma Hudson, Moira Cruickshank, Richard Quinton, Lorna Aucott, Magaly Aceves-Martins, Katie Gillies, Shalender Bhasin, Peter J Snyder, Susan S Ellenberg, Mathis Grossmann, Thomas G Travison, Emily J Gianatti, Yvonne T van der Schouw, Marielle H Emmelot-Vonk, Erik J Giltay, Geoff Hackett, Sudarshan Ramachandran, Johan Svartberg, Kerry L Hildreth, Kristina Groti Antonic, Gerald B Brock, J Lisa Tenover, Hui Meng Tan, Christopher Ho Chee Kong, Wei Shen Tan, Leonard S Marks, Richard J Ross, Robert S Schwartz, Paul Manson, Stephen Roberts, Marianne Skovsager Andersen, Line Velling Magnussen, Rodolfo Hernández, Nick Oliver, Frederick Wu, Waljit S Dhillo, Siladitya Bhattacharya, Miriam Brazzelli, Channa N Jayasena
Publikováno v:
e393
e381
The Lancet Healthy Longevity, 3(6), E381-E393. ELSEVIER
e381
The Lancet Healthy Longevity, 3(6), E381-E393. ELSEVIER
Background: Testosterone is the standard treatment for male hypogonadism, but there is uncertainty about its cardiovascular safety due to inconsistent findings. We aimed to provide the most extensive individual participant dataset (IPD) of testostero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c764047f3c18b6eb328d259767027d8
https://hdl.handle.net/1887/3563715
https://hdl.handle.net/1887/3563715
Autor:
Martin Whyte, Sud Ramachandran, Adrian H Heald, Mike Stedman, Mark Livingston, Marco Albanese, Geoff Hackett
Publikováno v:
Heald, A H, Stedman, M, Whyte, M, Livingston, M, Albanese, M, Ramachandran, S & Hackett, G 2021, ' Lessons learnt from the variation across 6741 family/general practices in England in the use of treatments for hypogonadism ', Clinical Endocrinology . https://doi.org/10.1111/cen.14412
Introduction We have previously reported rates of diagnosis of male hypogonadism in United Kingdom (UK) general practices. We aimed to identify factors associated with testosterone prescribing in UK general practice. Methods We determined for 6741 ge
Autor:
Karim Sultan Haider, Farid Saad, Pieter Desnerck, Nathan Lorde, Carola S. König, Amro Maarouf, A Haider, Sudarshan Ramachandran, Geoff Hackett, Richard C. Strange
Copyright © Nathan Lorde et al., 2021. Objective: Hematocrit (HCT)/hemoglobin (Hb) ratio in (%/g/dL) is around 3, with high fidelity between measured and derived Hb (applying the conversion using HCT) in various pathologies. We examined changes in H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::079c26285895384e064006f48950a3ff
https://eprints.keele.ac.uk/10164/1/andro.2021.0013.pdf
https://eprints.keele.ac.uk/10164/1/andro.2021.0013.pdf
Autor:
Amar Puttanna, Sudarshan Ramachandran, Abhishek Rao, Richard C. Strange, Farid Saad, Pieter Desnerck, Carola S. König, A Haider, Geoff Hackett, Karim Sultan Haider
Background: Klinefelter's syndrome (KS) is characterized by extra X chromosomes and features of primary hypogonadism including osteopenia and osteoporosis. Testosterone therapy (TTh) is widely used to treat men with KS and low serum testosterone/hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c707034f9b076119542ad67abc79aa1e
https://www.repository.cam.ac.uk/handle/1810/326085
https://www.repository.cam.ac.uk/handle/1810/326085