Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Geo Semini"'
Autor:
Geo Semini, Daniel Paape, Martin Blume, M. Fleur Sernee, Diego Peres-Alonso, Sébastien Calvignac-Spencer, Jörg Döllinger, Stefan Jehle, Eleanor Saunders, Malcolm J. McConville, Toni Aebischer
Publikováno v:
mBio, Vol 11, Iss 3 (2020)
ABSTRACT Leishmania spp. are protozoan parasites that cause a spectrum of important diseases in humans. These parasites develop as extracellular promastigotes in the digestive tract of their insect vectors and as obligate intracellular amastigotes th
Externí odkaz:
https://doaj.org/article/15f077c89e7b4930b189e22c358030ca
Publikováno v:
Analytical Chemistry. 90:8154-8161
We report the direct probing of the molecular composition of Leishmania-infected macrophage cells in vitro by surface-enhanced Raman scattering (SERS). The microscopic mapping data indicate local abundance and distribution of molecular species that a
Autor:
Sandra Schrötter, Geo Semini, Kerstin Danker, Sebastian Stricker, Sonja Häckel, Gudrun Mrawietz, Carsten Pelz, Vadim V. Shmanai, Lothar Lucka, Annette Hildmann, Willem Bintig, Britta J. Eickholt, Andreas Klein
Publikováno v:
Cellular oncology (Dordrecht). 41(5)
Previous studies have identified alkyl-phospholipids as promising compounds for cancer therapy by targeting constituents of the cell membrane and different signaling pathways. We previously showed that the alkylphospholipid Inositol-C2-PAF inhibits t
Autor:
Geo Semini, Toni Aebischer
Publikováno v:
International journal of medical microbiology : IJMM. 308(1)
Intracellular pathogens invade their host cells and replicate within specialized compartments. In turn, the host cell initiates a defensive response trying to kill the invasive agent. As a consequence, intracellular lifestyle implies morphological an
Autor:
Juliane Schroeder, Toni Aebischer, Daniel Paape, Martin E. Barrios-Llerena, Athina Paterou, Geo Semini
Publikováno v:
MicrobiologyOpen
Leishmania spp. are protozoan parasites that are transmitted by sandfly vectors during blood sucking to vertebrate hosts and cause a spectrum of diseases called leishmaniases. It has been demonstrated that host cholesterol plays an important role dur
Publikováno v:
Biophysical Journal. 116:565a
Autor:
Werner Reutter, Kerstin Danker, Claus Belka, Peter T. Daniel, Marco Sifringer, Clarissa von Haefen, Geo Semini, Silke Radetzki, Jana Wendt
Publikováno v:
Apoptosis. 16:636-651
Apoptosis is modulated by extrinsic and intrinsic signaling pathways through the formation of the death receptor-mediated death-inducing signaling complex (DISC) and the mitochondrial-derived apoptosome, respectively. Ino-C2-PAF, a novel synthetic ph
Publikováno v:
British Journal of Pharmacology. 160:36-47
Cell expansion and metastasis are considered hallmarks of tumour progression. Therefore, efforts have been made to develop novel anti-cancer drugs that inhibit both the proliferation and the motility of tumour cells. Synthetic alkylphospholipids, com
Autor:
Vadim V. Shmanai, Michael P. Schön, Geo Semini, Lothar Lucka, Annette Hildmann, Kerstin Danker, Andreas Klein, Margarete Schön
Publikováno v:
Biochemical pharmacology. 87(3)
In cutaneous inflammatory diseases, such as psoriasis, atopic dermatitis and allergic contact dermatitis, skin-infiltrating T lymphocytes and dendritic cells modulate keratinocyte function via the secretion of pro-inflammatory cytokines. Keratinocyte
Publikováno v:
Anti-cancer agents in medicinal chemistry. 14(4)
Synthetic alkylphospholipids (APLs), exhibit similarity to the platelet-activating factor (PAF). These compounds have antiproliferative effects on tumour cells and can therefore be regarded as a new class of drugs. Unlike classic cytostatic agents, s