Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Genzui Setsu"'
Autor:
Yoshiaki Yamaguchi, Iori Murai, Kaoru Goto, Shotaro Doi, Huihua Zhou, Genzui Setsu, Hiroyuki Shimatani, Hitoshi Okamura, Takahito Miyake, Masao Doi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Gpr19 encodes an evolutionarily conserved orphan G-protein-coupled receptor (GPCR) with currently no established physiological role in vivo. We characterized Gpr19 expression in the suprachiasmatic nucleus (SCN), the locus of the master circ
Externí odkaz:
https://doaj.org/article/fa41915671cb49aa8c6c451ead7970fe
Autor:
Masao Doi, Iori Murai, Sumihiro Kunisue, Genzui Setsu, Naohiro Uchio, Rina Tanaka, Sakurako Kobayashi, Hiroyuki Shimatani, Hida Hayashi, Hsu-Wen Chao, Yuuki Nakagawa, Yukari Takahashi, Yunhong Hotta, Jun-ichirou Yasunaga, Masao Matsuoka, Michael H. Hastings, Hiroshi Kiyonari, Hitoshi Okamura
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The suprachiasmatic nucleus (SCN) is the central regulator of circadian rhythms. Here the authors identify mouse Gpr176 as a pace modulator of this circadian clock and characterize its mode of action as coupling to Gz rather than Gi subunits.
Externí odkaz:
https://doaj.org/article/c16b11b6441e475eb897bd5b32fd2eac
Autor:
Ryutaro Kanada, Yoshiko Kagoshima, Takashi Suzuki, Akifumi Nakamura, Hideaki Funami, Jun Watanabe, Masayoshi Asano, Mizuki Takahashi, Osamu Ubukata, Kanae Suzuki, Tomoya Aikawa, Kazumi Sato, Megumi Goto, Genzui Setsu, Kentaro Ito, Kawori Kihara, Mutsumi Kuroha, Takashi Kohno, Hideaki Ogiwara, Takeshi Isoyama, Yuichi Tominaga, Saito Higuchi, Hiroyuki Naito
Publikováno v:
Journal of medicinal chemistry.
Histone acetylation is a post-translational modification of histones that is catalyzed by histone acetyltransferases (HATs) and plays an essential role in cellular processes. The HAT domain of EP300/CBP has recently emerged as a potential drug target
Autor:
Masao Doi, Genzui Setsu, Yoshiaki Yamaguchi, Kaoru Goto, Takahito Miyake, Iori Murai, Huihua Zhou, Hiroyuki Shimatani, Hitoshi Okamura, Shotaro Doi
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Background and Purpose: Gpr19 encodes an evolutionarily conserved orphan G-protein-coupled receptor (GPCR) with no established physiological function in vivo. The purpose of this study was to determine the role of Gpr19 in the circadian clock system.
Autor:
Akira Hirasawa, Kaoru Goto, Yoshiaki Yamaguchi, Tianyu Wang, Genzui Setsu, Hitoshi Okamura, Masao Doi, Shumpei Nakagawa, Takahito Miyake, Sumihiro Kunisue
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
G-protein-coupled receptors (GPCRs) are important drug targets with diverse therapeutic applications. However, there are still more than a hundred orphan GPCRs, whose protein functions and biochemical features remain unidentified. Gpr176 encodes a cl
Autor:
Hiroshi Kiyonari, Hsu Wen Chao, Hitoshi Okamura, Yuuki Nakagawa, Naohiro Uchio, Yukari Takahashi, Yunhong Hotta, Masao Matsuoka, Sakurako Kobayashi, Rina Tanaka, Michael H. Hastings, Iori Murai, Hida Hayashi, Sumihiro Kunisue, Jun-ichirou Yasunaga, Masao Doi, Genzui Setsu, Hiroyuki Shimatani
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
G-protein-coupled receptors (GPCRs) participate in a broad range of physiological functions. A priority for fundamental and clinical research, therefore, is to decipher the function of over 140 remaining orphan GPCRs. The suprachiasmatic nucleus (SCN