Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Genze Shao"'
Autor:
Xueyuan Guo, Yanfang Ma, Ting Zhang, Runyu Liu, Fen Chang, Xingyue Yan, Tianyun Yu, Pengfei Wu, Qin Li, Luzheng Xu, Junyi Duan, Li Li, Yanrong Su, Genze Shao
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract BRCA1 plays a suppressive role in breast tumorigenesis. Ubiquitin-dependent degradation is a common mechanism that regulates BRCA1 protein stability, and several ubiquitin ligases involved have been identified. However, the deubiquitinating
Externí odkaz:
https://doaj.org/article/4b142915c92d458fbd4b88c70a11f05a
Autor:
Junyi Duan, Daoyuan Huang, Cheng Liu, Yangbo Lv, Lei Zhang, Fen Chang, Xiangyu Zeng, Li Li, Weiping Wang, Genze Shao
Publikováno v:
Cell Death and Disease, Vol 14, Iss 7, Pp 1-15 (2023)
Abstract Ferroptosis is an iron-dependent form of regulated cell death characterized by lipid peroxidation. Colorectal cancer (CRC) cells evade ferroptosis despite their requirement of substantial iron and reactive oxygen species (ROS) to sustain act
Externí odkaz:
https://doaj.org/article/2b925fb1cd0e4d19a980de5c6c7fd7f7
Autor:
Qin Li, Yanfang Ma, Fen Chang, Yongjie Xu, Jingcheng Deng, Junyi Duan, Wei Jiang, Qihua He, Luzheng Xu, Lijun Zhong, Genze Shao, Li Li
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-16 (2022)
The BRCC36 isopeptidase complex (BRISC) is identified as the deubiquitinating enzyme for Lys63-linked ubiquitination of Aurora B, and hyperactivated Aurora B in the absence of BRISC leads to erroneous chromosome–microtubule attachment during mitosi
Externí odkaz:
https://doaj.org/article/3dab4287fcfb4bd187bd12194cafb1d0
Autor:
Yongjie Xu, Yumeng Hu, Tao Xu, Kaowen Yan, Ting Zhang, Qin Li, Fen Chang, Xueyuan Guo, Jingyu Peng, Mo Li, Min Zhao, Hongying Zhen, Luzheng Xu, Duo Zheng, Li Li, Genze Shao
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109854- (2021)
Summary: Despite the tremendous success of targeted and conventional therapies for lung cancer, therapeutic resistance is a common and major clinical challenge. RNF8 is a ubiquitin E3 ligase that plays essential roles in the DNA damage response; howe
Externí odkaz:
https://doaj.org/article/eb9f97f9ca6940cdb3d5cc14ca584de7
Autor:
Chenyang Xue, Wei Chen, Aiwu Yuan, Cheng Chen, Shuaihu Li, Kai Chen, Yang Zhao, Tian Xiao, Genze Shao, Yongdong Zou, Duo Zheng
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Opioids are a potential adjuvant treatment for certain cancers; while they are primarily used to relieve chronic pain, these drugs may also affect cancer progression and recurrence. Dezocine is one opioid commonly used in China, but its effects on ca
Externí odkaz:
https://doaj.org/article/dff2561993bb42b081ebaf5d5c05073e
Autor:
Jingcheng, Deng, Ting, Zhang, Fei, Liu, Qianying, Han, Qin, Li, Xueyuan, Guo, Yanfang, Ma, Li, Li, Genze, Shao
Publikováno v:
Biochemical and Biophysical Research Communications. 611:107-113
BARD1 is a tumor suppressor that is necessary for the functioning and stability of BRCA1, with which it forms a heterodimer and participates in the repair of DNA double-strand breaks. The cellular level of BARD1 and its interaction with BRCA1 are cru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::969d4c464f486d8763d387417f3200b2
https://doi.org/10.1016/j.bbrc.2022.04.100
https://doi.org/10.1016/j.bbrc.2022.04.100
Autor:
Yongliang Zhao, Tom K. Hei, Govind Bhagat, Adayabalam S. Balajee, Hongbo Fang, Chyuansheng Lin, Cuidong Wang, Genze Shao, Gengyun Wen, Ye Zhang
Loss of TGFBI, a secreted protein induced by transforming growth factor-β, has been implicated in cell proliferation, tumor progression, and angiogenesis by in vitro studies. However, in vivo antitumor functions of TGFBI as well as the underlying mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d773616a86a8ecb94741af0ed63e77
https://doi.org/10.1158/0008-5472.c.6497825
https://doi.org/10.1158/0008-5472.c.6497825
Autor:
Fei, Liu, Qianying, Han, Ting, Zhang, Fen, Chang, Jingcheng, Deng, Xiaotian, Huang, Weiping, Wang, Yongjie, Xu, Qin, Li, Luzheng, Xu, Bo, Zhang, Wentong, Li, Li, Li, Yanrong, Su, Yang, Li, Genze, Shao
Publikováno v:
International Journal of Biological Sciences. 18:1434-1450
BRCA1 is frequently down-regulated in breast cancer, the underlying mechanism is unclear. Here we identified DCAF8L1, an X-linked gene product, as a DDB1-Cullin associated Factor (DCAF) for CUL4 E3 ligases to target BRCA1 and BARD1 for proteasomal de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46afd3b7bc18d3043f3829efb53cee93
https://doi.org/10.7150/ijbs.57178
https://doi.org/10.7150/ijbs.57178
Publikováno v:
Oncogene. 40:1706-1720
The transcription factor nuclear factor (erythroid-derived 2)-like 2 (NRF2) plays a key role in cancer progression and is tightly regulated by the proteasome pathway. E3 ligases that mediate NRF2 ubiquitination have been widely reported, but the mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc32af1c07a79100b95ada3aae53d27d
https://doi.org/10.1038/s41388-021-01660-5
https://doi.org/10.1038/s41388-021-01660-5
Autor:
Wei Chen, Yongdong Zou, Aiwu Yuan, Cheng Chen, Kai Chen, Duo Zheng, Genze Shao, Tian Xiao, Chenyang Xue, Shuaihu Li, Yang Zhao
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology
Frontiers in Pharmacology
Opioids are a potential adjuvant treatment for certain cancers; while they are primarily used to relieve chronic pain, these drugs may also affect cancer progression and recurrence. Dezocine is one opioid commonly used in China, but its effects on ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::762ca3fd45ab7ca7c2ec278d438d425d
https://www.frontiersin.org/articles/10.3389/fphar.2021.600296/full
https://www.frontiersin.org/articles/10.3389/fphar.2021.600296/full