Zobrazeno 1 - 10
of 222
pro vyhledávání: '"Geny M M, Groothuis"'
Autor:
Keumhan Noh, Edwin C. Y. Chow, Holly P. Quach, Geny M. M. Groothuis, Rommel G. Tirona, K. Sandy Pang
Publikováno v:
Aaps journal. 24(4)
The vitamin D receptor (VDR), in addition to other nuclear receptors, the pregnane X receptor (PXR) and constitutive androstane receptor (CAR), is involved in the regulation of enzymes, transporters and receptors, and therefore intimately affects dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fdbfcbedca844754ed23d78ce32efba
http://www.scopus.com/inward/record.url?scp=85131136866&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85131136866&partnerID=8YFLogxK
Autor:
Erika R Amstalden van Hove, Geny M. M. Groothuis, Jiaying Han, Peter Horvatovich, Cornelia J Verhoeven, Rainer Bischoff, Hjalmar P. Permentier, Shanshan Song, Gyorgy B. Halmos, Angela Casini, Leonie Beljaars, Jing Sun
Publikováno v:
Chemical communications (Cambridge, England), 56(44), 5941-5944. ROYAL SOC CHEMISTRY
Chemical Communications, 56(44), 5941-5944. Royal Society of Chemistry
Han, J, Sun, J, Song, S, Beljaars, L, Groothuis, G M M, Permentier, H, Bischoff, R, Halmos, G B, Verhoeven, C J, Amstalden van Hove, E R, Horvatovich, P & Casini, A 2020, ' Targeted imaging of integrins in cancer tissues using photocleavable Ru(ii) polypyridine complexes as mass-tags ', Chemical Communications, vol. 56, no. 44, pp. 5941-5944 . https://doi.org/10.1039/d0cc00774a
Chemical Communications, 56(44), 5941-5944. Royal Society of Chemistry
Han, J, Sun, J, Song, S, Beljaars, L, Groothuis, G M M, Permentier, H, Bischoff, R, Halmos, G B, Verhoeven, C J, Amstalden van Hove, E R, Horvatovich, P & Casini, A 2020, ' Targeted imaging of integrins in cancer tissues using photocleavable Ru(ii) polypyridine complexes as mass-tags ', Chemical Communications, vol. 56, no. 44, pp. 5941-5944 . https://doi.org/10.1039/d0cc00774a
Targeted epitope-based mass spectrometry imaging (MSI) utilizes laser cleavable mass-tags bound to targeting moieties for detecting proteins in tissue sections. Our work constitutes the first proof-of-concept of a novel laser desorption ionization (L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dca81b623b46beefc07b7ec2d3e2289
http://www.scopus.com/inward/record.url?scp=85084043683&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85084043683&partnerID=8YFLogxK
Autor:
Gildardo Rivera, Irma Edith Carranza-Torres, Nadia Denys Betancourt-Martínez, Pilar Carranza-Rosales, Geny M. M. Groothuis, Sara García-Davis, Javier Morán-Martínez, I.A.M. de Graaf, Nancy Elena Guzmán-Delgado
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports, 9:8396. Nature Publishing Group
Scientific Reports
Scientific Reports, 9:8396. Nature Publishing Group
Amoebiasis is a parasitic disease that causes thousands of deaths every year, its adverse effects and resistance to conventional treatments have led to the search of new treatment options, as well as the development of novel screening methods. In thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c7ac7bb0cc24565806784723a6f2973
http://link.springer.com/article/10.1038/s41598-019-44899-5
http://link.springer.com/article/10.1038/s41598-019-44899-5
Autor:
Angela Casini, Hjalmar P. Permentier, Geny M. M. Groothuis, Peter Horvatovich, Jiaying Han, Rainer Bischoff
Publikováno v:
TrAC Trends in Analytical Chemistry. 112:13-28
The recent development of mass spectrometry imaging (MSI) technology allowed to obtain extremely detailed images of the spatial distribution of proteins in tissue at high spatial resolution reaching cell dimensions, high target specificity and a larg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e28461797aa082046ac51e904784690
https://doi.org/10.1016/j.trac.2018.12.016
https://doi.org/10.1016/j.trac.2018.12.016
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95462 (2014)
Two important signaling pathways in liver fibrosis are the PDGF- and TGFβ pathway and compounds inhibiting these pathways are currently developed as antifibrotic drugs. Testing antifibrotic drugs requires large numbers of animal experiments with hig
Externí odkaz:
https://doaj.org/article/b71651fb584e4b05980e273a07652e89
Autor:
Tjitske A Oenema, Harm Maarsingh, Marieke Smit, Geny M M Groothuis, Herman Meurs, Reinoud Gosens
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65580 (2013)
Airway remodelling, including smooth muscle remodelling, is a primary cause of airflow limitation in asthma. Recent evidence links bronchoconstriction to airway remodelling in asthma. The mechanisms involved are poorly understood. A possible player i
Externí odkaz:
https://doaj.org/article/054f34fd3c7a4061b407e60f6dc9d9a1
Bioconjugation of Supramolecular Metallacages to Integrin Ligands for Targeted Delivery of Cisplatin
Autor:
Jiaying Han, Michael Weinmüller, Brech Aikman, Andreas F B Räder, Florian Reichart, Horst Kessler, Rainer Bischoff, Margot N. Wenzel, Angela Casini, Beatrice S Ludwig, Ben Woods, Peter Horvatovich, Hjalmar P. Permentier, Geny M. M. Groothuis, Stefan Stürup
Publikováno v:
BIOCONJUGATE CHEMISTRY, 29(11), 3856-3865. AMER CHEMICAL SOC
Cisplatin occupies a crucial role in the treatment of various malignant tumours. However, its efficacy and applicability are heavily restricted by severe systemic toxicities and drug resistance. Our study exploits the active targeting of supramolecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6433cb82bbe8a15738500fd7aa8658
https://doi.org/10.1021/acs.bioconjchem.8b00682
https://doi.org/10.1021/acs.bioconjchem.8b00682
Autor:
Bernard Evers, Inge A. M. de Graaf, Ivan Vokral, Ming Li, Marina H. de Jager, Geny M. M. Groothuis
Publikováno v:
European Journal of Pharmaceutical Sciences, 121, 65-73. ELSEVIER SCIENCE BV
The apical sodium-dependent bile acid transporter (ASBT) is the primary transporter for the uptake of bile acids in the small intestine. It is localized on the apical membrane of the ileal enterocytes and is known for its high capacity and affinity f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e0bb8e654e662d7cbcbc4d10dd5aab
https://doi.org/10.1016/j.ejps.2018.05.005
https://doi.org/10.1016/j.ejps.2018.05.005
Autor:
Anders Aspegren, Viktoriia Starokozhko, Anders Wolff, Soumyaranjan Mohanty, Marjolijn T. Merema, Layla Bashir Larsen, Jenny Emnéus, Rodrigo Pimentel, Mette Hemmingsen, Martin Dufva, Geny M. M. Groothuis
Publikováno v:
Journal of Tissue Engineering and Regenerative Medicine
Journal of tissue engineering and regenerative medicine, 12(5), 1273-1284. Wiley
Starokozhko, V, Hemmingsen, M, Larsen, L, Mohanty, S, Merema, M, Pimentel, R C, Wolff, A, Emnéus, J, Aspegren, A, Groothuis, G & Dufva, M 2018, ' Differentiation of human-induced pluripotent stem cell under flow conditions to mature hepatocytes for liver tissue engineering ', Journal of Tissue Engineering and Regenerative Medicine, vol. 12, no. 5, pp. 1273-1284 . https://doi.org/10.1002/term.2659
Journal of tissue engineering and regenerative medicine, 12(5), 1273-1284. Wiley
Starokozhko, V, Hemmingsen, M, Larsen, L, Mohanty, S, Merema, M, Pimentel, R C, Wolff, A, Emnéus, J, Aspegren, A, Groothuis, G & Dufva, M 2018, ' Differentiation of human-induced pluripotent stem cell under flow conditions to mature hepatocytes for liver tissue engineering ', Journal of Tissue Engineering and Regenerative Medicine, vol. 12, no. 5, pp. 1273-1284 . https://doi.org/10.1002/term.2659
Hepatic differentiation of human‐induced pluripotent stem cells (hiPSCs) under flow conditions in a 3D scaffold is expected to be a major step forward for construction of bioartificial livers. The aims of this study were to induce hepatic different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a110fbd6b99a3e95483908c260d53e5
https://doi.org/10.1002/term.2659
https://doi.org/10.1002/term.2659
Autor:
Sara Ongay, Hermen S. Overkleeft, Marcel P. Stoop, Geny M. M. Groothuis, Rainer Bischoff, Theo M. Luider, Miriam Langelaar-Makkinje, Nora Liu
Publikováno v:
ChemBioChem, 19, 736-743. WILEY-V C H VERLAG GMBH
ChemBioChem, 19(7), 736-743. Wiley-VCH
ChemBioChem, 19(7), 736-743. Wiley-VCH
Formaldehyde fixation is widely used for long-term maintenance of tissue. However, due to formaldehyde-induced crosslinks, fixed tissue proteins are difficult to extract, which hampers mass spectrometry (MS) proteomic analyses. Recent years have seen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db987e3a063014e9b2184c45d95f974
https://doi.org/10.1002/cbic.201700625
https://doi.org/10.1002/cbic.201700625