Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Genus J. Possanza"'
Autor:
Sorcek Ronald J, L. Churchill, Lazer Edward S, Genus J. Possanza, Charles L. Cywin, Diane Thome, A. G. Graham
Publikováno v:
ChemInform. 29
A series of 2-benzyl-4-sulfonyl-4H-isoquinoline-1,3-diones was prepared. Members of this series are potent and selective inhibitors of cyclooxygenase-2 (COX-2) in both microsomal and cellular assays. Two representatives demonstrated activity in the c
Autor:
Charles L. Cywin, Diane Thome, Lazer Edward S, A. G. Graham, Sorcek Ronald J, L. Churchill, Genus J. Possanza
Publikováno v:
Bioorganicmedicinal chemistry letters. 8(10)
A series of 2-benzyl-4-sulfonyl-4H-isoquinoline-1,3-diones was prepared. Members of this series are potent and selective inhibitors of cyclooxygenase-2 (COX-2) in both microsomal and cellular assays. Two representatives demonstrated activity in the c
Autor:
Sorcek Ronald J, Miao Clara K, Philip W. Mui, Grace C. Chow, Genus J. Possanza, Jerry W. Skiles, Skoog M, Stephen Jacober, Weldon Sm, Keirns J
Publikováno v:
Journal of medicinal chemistry. 35(26)
A series of tripeptides which contain alpha,alpha-difluorostatone residues at P1-P1' and span the S3-S1' subsites have been shown to be potent inhibitors of human leukocyte elastase (HLE). The tripeptides described contain the nonproteinogenic achira
Autor:
Thelma LeClerq, Hin Chor Wong, Kurt Freter, Ernest Cullen, Reinhold Becker, Genus J. Possanza
Publikováno v:
Journal of medicinal chemistry. 35(2)
A series of benzobisthiazoles were screened for antiinflammatory activity in the carrageenan paw edema and adjuvant arthritis tests. Compound 26, 2,6-bis(N,N-diethylamino)benzo[1,2-d:5,4-d']bisthiazole, was found to inhibit the swelling of the uninje
Publikováno v:
Journal of Medicinal Chemistry. 32:100-104
A series of 2,6-di-tert-butyl-4-(2-arylethenyl)phenols was prepared and examined for their ability to inhibit cyclooxygenase and 5-lipoxygenase in vitro and developing adjuvant arthritis in vivo in the rat. Structure-activity relationships are discus
Autor:
Robert C. Troop, Genus J. Possanza
Publikováno v:
Archives of Biochemistry and Biophysics. 98:444-449
Quartered adrenals from male and female rats produce the same quantity of corticoids when incubated for 2 hr. Castration reduces steroid production sharply and equally in the two sexes. Addition to the adrenals of fluid in which pituitary glands have
Publikováno v:
Journal of medicinal chemistry. 30(4)
A number of substituted 2-[(2,2,2-trifluoroethyl)sulfonyl]-1H-benzimidazoles (4) have demonstrated antiinflammatory activity that appears to have a mechanism distinct from typical cyclooxygenase inhibiting nonsteroidal antiinflammatory drugs. Several
Publikováno v:
ChemInform. 18
A number of substituted 2-[(2,2,2-trifluoroethyl)sulfonyl]-1H-benzimidazoles (4) have demonstrated antiinflammatory activity that appears to have a mechanism distinct from typical cyclooxygenase inhibiting nonsteroidal antiinflammatory drugs. Several
Publikováno v:
Journal of medicinal chemistry. 21(5)
The synthesis and properties of the title compounds 1 are described. Several of these compounds, in addition to being potent inhibitors of the passive cutaneous anaphylaxis reaction of rats against egg albumin challenge, significantly block the effec
Publikováno v:
Chemischer Informationsdienst. 9
In Gegenwart von Natriumhydrid kondensieren die 2-Acetyl-3-hydroxy-dibenzopyrane (I) mit Diethylcarbonat (II) zu Benzopyrano-benzopyranen (III), die in Tabellen aufgefuhrt werden.