The in vivo efficacy and side effect pharmacology of GS-5759, a novel bifunctional phosphodiesterase 4 inhibitor and long-acting β2-adrenoceptor agonist in preclinical animal species

Autor: Salmon, Michael, Tannheimer, Stacey L, Gentzler, Terry T, Cui, Zhi-Hua, Sorensen, Eric A, Hartsough, Kimberly C, Kim, Musong, Purvis, Lafe J, Barrett, Edward G, McDonald, Jacob D, Rudolph, Karin, Doyle-Eisele, Melanie, Kuehl, Philip J, Royer, Christopher M, Baker, William R, Phillips, Gary B, Wright, Clifford D

Publikováno v: Pharmacology Research & Perspectives

Bronchodilators are a central therapy for symptom relief in respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma, with inhaled β 2-adrenoceptor agonists and anticholinergics being the primary treatments available. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::de42727a2f818c436803ab8310691ad7
http://europepmc.org/articles/PMC4186437

The in vivo efficacy and side effect pharmacology of GS-5759, a novel bifunctional phosphodiesterase 4 inhibitor and long-acting β 2-adrenoceptor agonist in preclinical animal species.

Autor: Salmon M; Oncology/Inflammation Research, Gilead Sciences Inc. 199 East Blaine Street, Seattle, Washington, 98102 ; Merck Research Laboratories 33 Avenue Louis Pasteur, Boston, Massachusetts, 02115., Tannheimer SL; Oncology/Inflammation Research, Gilead Sciences Inc. 199 East Blaine Street, Seattle, Washington, 98102., Gentzler TT; Oncology/Inflammation Research, Gilead Sciences Inc. 199 East Blaine Street, Seattle, Washington, 98102., Cui ZH; Oncology/Inflammation Research, Gilead Sciences Inc. 199 East Blaine Street, Seattle, Washington, 98102., Sorensen EA; Oncology/Inflammation Research, Gilead Sciences Inc. 199 East Blaine Street, Seattle, Washington, 98102., Hartsough KC; Oncology/Inflammation Research, Gilead Sciences Inc. 199 East Blaine Street, Seattle, Washington, 98102., Kim M; Medicinal Chemistry, Gilead Sciences Inc. 199 East Blaine Street, Seattle, Washington, 98102., Purvis LJ; Medicinal Chemistry, Gilead Sciences Inc. 199 East Blaine Street, Seattle, Washington, 98102., Barrett EG; Lovelace Respiratory Research Institute 2425 Ridgecrest Drive SE, Albuquerque, New Mexico, 87108., McDonald JD; Lovelace Respiratory Research Institute 2425 Ridgecrest Drive SE, Albuquerque, New Mexico, 87108., Rudolph K; Lovelace Respiratory Research Institute 2425 Ridgecrest Drive SE, Albuquerque, New Mexico, 87108., Doyle-Eisele M; Lovelace Respiratory Research Institute 2425 Ridgecrest Drive SE, Albuquerque, New Mexico, 87108., Kuehl PJ; Lovelace Respiratory Research Institute 2425 Ridgecrest Drive SE, Albuquerque, New Mexico, 87108., Royer CM; Lovelace Respiratory Research Institute 2425 Ridgecrest Drive SE, Albuquerque, New Mexico, 87108., Baker WR; Medicinal Chemistry, Gilead Sciences Inc. 199 East Blaine Street, Seattle, Washington, 98102., Phillips GB; Medicinal Chemistry, Gilead Sciences Inc. 199 East Blaine Street, Seattle, Washington, 98102., Wright CD; Oncology/Inflammation Research, Gilead Sciences Inc. 199 East Blaine Street, Seattle, Washington, 98102.

Publikováno v: Pharmacology research & perspectives [Pharmacol Res Perspect] 2014 Aug; Vol. 2 (4), pp. e00046. Date of Electronic Publication: 2014 Jun 09.