Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Gentry N Patrick"'
Autor:
Esther Magdalena Marquez-Lona, Ana Lilia Torres-Machorro, Frankie R Gonzales, Lorraine Pillus, Gentry N Patrick
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179893 (2017)
The ubiquitin proteasome system (UPS) is a highly conserved and tightly regulated biochemical pathway that degrades the majority of proteins in eukaryotic cells. Importantly, the UPS is responsible for counteracting altered protein homeostasis induce
Externí odkaz:
https://doaj.org/article/5091015b3aa94407bdbb32294aaba230
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 8 (2015)
Changes in synaptic strength underlie the basis of learning and memory and are controlled, in part, by the insertion or removal of AMPA-type glutamate receptors at the postsynaptic membrane of excitatory synapses. Once internalized, these receptors m
Externí odkaz:
https://doaj.org/article/2ba918ccd4a648888357706721cab832
Autor:
Anna E Cartier, Kiren Ubhi, Brian Spencer, Ruben A Vazquez-Roque, Kori Ann Kosberg, Lawrence Fourgeaud, Priya Kanayson, Christina Patrick, Edward Rockenstein, Gentry N Patrick, Eliezer Masliah
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34713 (2012)
Parkinson's disease (PD) is a progressive neurodegenerative disorder caused by genetic and environmental factors. Abnormal accumulation and aggregation of alpha-synuclein (a-syn) within neurons, and mutations in the a-syn and UCH-L1 genes have been s
Externí odkaz:
https://doaj.org/article/6736a6b45848464985bfbf6c1dee8cc4
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13465 (2010)
The ubiquitin proteasome system (UPS) mediates the majority of protein degradation in eukaryotic cells. The UPS has recently emerged as a key degradation pathway involved in synapse development and function. In order to better understand the function
Externí odkaz:
https://doaj.org/article/2de1f7e5faa74db5b936c9d15f45fa5e
Autor:
Gema Lordén, Jacob M. Wozniak, Kim Doré, Lara E. Dozier, Chelsea Cates-Gatto, Gentry N. Patrick, David J. Gonzalez, Amanda J. Roberts, Rudolph E. Tanzi, Alexandra C. Newton
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Mutations that enhance the activity of protein kinase C alpha (PKCα) are associated with Alzheimer’s Disease. Here, the authors report that the enhanced activity of one variant, PKCα M489V, is sufficient to rewire the brain phosphoproteome, drive
Externí odkaz:
https://doaj.org/article/f626c5ecba534cfcaa1608a36cecb5d0
Autor:
Jessica A. Lawrence, Patricia Aguilar-Calvo, Daniel Ojeda-Juárez, Helen Khuu, Katrin Soldau, Donald P. Pizzo, Jin Wang, Adela Malik, Timothy F. Shay, Erin E. Sullivan, Brent Aulston, Seung Min Song, Julia A. Callender, Henry Sanchez, Michael D. Geschwind, Subhojit Roy, Robert A. Rissman, JoAnn Trejo, Nobuyuki Tanaka, Chengbiao Wu, Xu Chen, Gentry N. Patrick, Christina J. Sigurdson
Endolysosomal defects in neurons are central to the pathogenesis of prion and other neurodegenerative disorders. In prion disease, prion oligomers traffic through the multivesicular body (MVB) and are routed for degradation in lysosomes or for releas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::705eb5fb234b7b59deca02c92f6096bb
https://resolver.caltech.edu/CaltechAUTHORS:20230719-853619100.5
https://resolver.caltech.edu/CaltechAUTHORS:20230719-853619100.5
Publikováno v:
Angewandte Chemie International Edition. 62
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e37574a9fb2c399aa2301d8ad9f038c
https://doi.org/10.1002/anie.202216784
https://doi.org/10.1002/anie.202216784
Autor:
Daniel Ojeda-Juárez, Jessica A. Lawrence, Katrin Soldau, Donald P. Pizzo, Emily Wheeler, Patricia Aguilar-Calvo, Helen Khuu, Joy Chen, Adela Malik, Gail Funk, Percival Nam, Henry Sanchez, Michael D. Geschwind, Chengbiao Wu, Gene W. Yeo, Xu Chen, Gentry N. Patrick, Christina J. Sigurdson
Publikováno v:
Neurobiology of disease. 172
Synapse dysfunction and loss are central features of neurodegenerative diseases, caused in part by the accumulation of protein oligomers. Amyloid-β, tau, prion, and α-synuclein oligomers bind to the cellular prion protein (PrP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::249bc57ad83a04fdc4d5078066a24f7e
https://pubmed.ncbi.nlm.nih.gov/35905927
https://pubmed.ncbi.nlm.nih.gov/35905927
Autor:
Jacob M. Wozniak, Amanda J. Roberts, Alexandra C. Newton, Kim Dore, Chelsea Cates-Gatto, Lara E. Dozier, Gema Lordén, Rudolph E. Tanzi, David Gonzalez, Gentry N. Patrick
Exquisitely tuned activity of protein kinase C (PKC) isozymes is essential to maintaining cellular homeostasis. Whereas loss-of-function mutations are generally associated with cancer, gain-of-function variants in one isozyme, PKCα, are associated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ceb6055be8d12b624b0737347ad204b
https://doi.org/10.21203/rs.3.rs-894083/v1
https://doi.org/10.21203/rs.3.rs-894083/v1
Autor:
Gema Lordén, Jacob M. Wozniak, Kim Doré, Lara E. Dozier, Chelsea Cates-Gatto, Gentry N. Patrick, David J. Gonzalez, Amanda J. Roberts, Rudolph E. Tanzi, Alexandra C. Newton
Publikováno v:
Nature communications. 13(1)
Exquisitely tuned activity of protein kinase C (PKC) isozymes is essential to maintaining cellular homeostasis. Whereas loss-of-function mutations are generally associated with cancer, gain-of-function variants in one isozyme, PKCα, are associated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af5421033528c14cf48ccd84dc57aa2
https://pubmed.ncbi.nlm.nih.gov/36418293
https://pubmed.ncbi.nlm.nih.gov/36418293