Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Genta Kakiyama"'
Autor:
Kei Minowa, Daniel Rodriguez-Agudo, Mitsuyoshi Suzuki, Yamato Muto, Saeko Hirai, Yaping Wang, Lianyong Su, Huiping Zhou, Qun Chen, Edward J. Lesnefsky, Kuniko Mitamura, Shigeo Ikegawa, Hajime Takei, Hiroshi Nittono, Michael Fuchs, William M. Pandak, Genta Kakiyama
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 5, Pp 100363- (2023)
CYP7B1 catalyzes mitochondria-derived cholesterol metabolites such as (25R)26-hydroxycholesterol (26HC) and 3β-hydroxy-5-cholesten-(25R)26-oic acid (3βHCA) and facilitates their conversion to bile acids. Disruption of 26HC/3βHCA metabolism in the
Externí odkaz:
https://doaj.org/article/ad9e745a75d64f8194bdbfb5527e40ba
Autor:
Hajime Takei, Seiko Narushima, Mitsuyoshi Suzuki, Genta Kakiyama, Takahiro Sasaki, Tsuyoshi Murai, Yuichiro Yamashiro, Hiroshi Nittono
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 10, Pp 100275- (2022)
Although most bile acids (BAs) in feces are present in noncovalent forms that can be extracted with ethanol, non-negligible amounts of saponifiable BAs are also present. It is a major concern that such saponifiable BAs are routinely omitted from feca
Externí odkaz:
https://doaj.org/article/532be0ea86c34217bacd055e6322d0b7
Publikováno v:
Cells, Vol 12, Iss 10, p 1434 (2023)
The rising prevalence of nonalcoholic fatty liver disease (NAFLD)-related cirrhosis highlights the need for a better understanding of the molecular mechanisms responsible for driving the transition of hepatic steatosis (fatty liver; NAFL) to steatohe
Externí odkaz:
https://doaj.org/article/e1966613097e417a8a51cd15658da5ba
Autor:
Patricia G. Wolf, Saravanan Devendran, Heidi L. Doden, Lindsey K. Ly, Tyler Moore, Hajime Takei, Hiroshi Nittono, Tsuyoshi Murai, Takao Kurosawa, George E. Chlipala, Stefan J. Green, Genta Kakiyama, Purna Kashyap, Vance J. McCracken, H. Rex Gaskins, Patrick M. Gillevet, Jason M. Ridlon
Publikováno v:
BMC Microbiology, Vol 21, Iss 1, Pp 1-15 (2021)
Abstract Background Berberine (BBR) is a plant-based nutraceutical that has been used for millennia to treat diarrheal infections and in contemporary medicine to improve patient lipid profiles. Reduction in lipids, particularly cholesterol, is achiev
Externí odkaz:
https://doaj.org/article/cc181af431b94f74a2e7f625680bba8b
Autor:
Genta Kakiyama, Dalila Marques, Rebecca Martin, Hajime Takei, Daniel Rodriguez-Agudo, Sandra A. LaSalle, Taishi Hashiguchi, Xiaoying Liu, Richard Green, Sandra Erickson, Gregorio Gil, Michael Fuchs, Mitsuyoshi Suzuki, Tsuyoshi Murai, Hiroshi Nittono, Phillip B. Hylemon, Huiping Zhou, William M. Pandak
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 12, Pp 1629-1644 (2020)
NAFLD is an important public health issue closely associated with the pervasive epidemics of diabetes and obesity. Yet, despite NAFLD being among the most common of chronic liver diseases, the biological factors responsible for its transition from be
Externí odkaz:
https://doaj.org/article/f22dc345203d48c1bae1f66f709fdca2
Autor:
Jason M. Ridlon, Saravanan Devendran, João Mp Alves, Heidi Doden, Patricia G. Wolf, Gabriel V. Pereira, Lindsey Ly, Alyssa Volland, Hajime Takei, Hiroshi Nittono, Tsuyoshi Murai, Takao Kurosawa, George E. Chlipala, Stefan J. Green, Alvaro G. Hernandez, Christopher J. Fields, Christy L. Wright, Genta Kakiyama, Isaac Cann, Purna Kashyap, Vance McCracken, H. Rex Gaskins
Publikováno v:
Gut Microbes, Vol 11, Iss 3, Pp 381-404 (2020)
The formation of secondary bile acids by gut microbes is a current topic of considerable biomedical interest. However, a detailed understanding of the biology of anaerobic bacteria in the genus Clostridium that are capable of generating secondary bil
Externí odkaz:
https://doaj.org/article/e86dc56997764544b9457a22c77e5788
Autor:
Yamato Muto, Mitsuyoshi Suzuki, Genta Kakiyama, Takahiro Sasaki, Tsuyoshi Murai, Hajime Takei, Hiroshi Nittono
Publikováno v:
Metabolites, Vol 12, Iss 12, p 1230 (2022)
We investigated the age-dependent changes in urinary excretion of glucuronidated bile acids at the C-3 position. Bile acid 3-glucuronides accounted for 0.5% of urinary bile acids in neonates, and the proportion of bile acid 3-glucuronides plateaued a
Externí odkaz:
https://doaj.org/article/7e2734fb042d40c5beea2d2e71108661
Autor:
William M. Pandak, Genta Kakiyama
Publikováno v:
Liver Research, Vol 3, Iss 2, Pp 88-98 (2019)
Over the last two decades, the prevalence of obesity, and metabolic syndromes (MS) such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM), have dramatically increased. Bile acids play a major role in the digestion, abso
Externí odkaz:
https://doaj.org/article/fb8f2d218a3d4218a405103292cfb80c
Autor:
Daniel Rodriguez-Agudo, Leonel Malacrida, Genta Kakiyama, Tavis Sparrer, Carolina Fortes, Michael Maceyka, Mark A. Subler, Jolene J. Windle, Enrico Gratton, William M. Pandak, Gregorio Gil
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 6, Pp 1087-1098 (2019)
How plasma membrane (PM) cholesterol is controlled is poorly understood. Ablation of the gene encoding the ER stress steroidogenic acute regulatory-related lipid transfer domain (StarD)5 leads to a decrease in PM cholesterol content, a decrease in ch
Externí odkaz:
https://doaj.org/article/b9c9fc18d2e84c2ebc2b6623be3dd211
Autor:
Yanyan Wang, Yun-Ling Tai, Derrick Zhao, Yuan Zhang, Junkai Yan, Genta Kakiyama, Xuan Wang, Emily C. Gurley, Jinze Liu, Jinpeng Liu, Jimin Liu, Guanhua Lai, Phillip B. Hylemon, William M. Pandak, Weidong Chen, Huiping Zhou
Publikováno v:
Cells, Vol 10, Iss 2, p 210 (2021)
Background and Aims: The disease progression of nonalcoholic fatty liver disease (NAFLD) from simple steatosis (NAFL) to nonalcoholic steatohepatitis (NASH) is driven by multiple factors. Berberine (BBR) is an ancient Chinese medicine and has various
Externí odkaz:
https://doaj.org/article/196a8eaf79bc4c698900c2d12f6a79c8