Výsledky vyhledávání - "Gensaku, Okada"

Multiple factors influencing the release of hTERT mRNA from pancreatic cancer cell lines inin vitroculture

Autor: Yoshiharu Motoo, Gensaku Okada, Koushiro Ohtsubo, Hisatsugu Mouri, Hiroyuki Watanabe, Norio Sawabu, Yasushi Yamaguchi

Publikováno v: Cell Biology International. 36:545-553

Since telomerase expression is highly prevalent in human cancers, the quantitation of serum/plasma hTERT (human telomerase reverse transcriptase) mRNA levels may be useful for early detection of PCa (pancreatic cancer). To analyse the correspondence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edac163d262eaab0ce990cb735a8b575
https://doi.org/10.1042/cbi20090471

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Preproenkephalin hypermethylation in the pure pancreatic juice compared with p53 mutation in the diagnosis of pancreatic carcinoma

Autor: Hisatsugu Mouri, Koushiro Ohtsubo, F. Yao, Yasushi Yamaguchi, Hiroyuki Watanabe, Norio Sawabu, Gensaku Okada

Publikováno v: Journal of Gastroenterology. 41:791-797

Aberrant methylation of CpG islands is a common mechanism for the dysregulation of tumor suppressor genes in a variety of human malignancies. Preproenkephalin ppENK) hypermethylation is recognized in 90% of pancreatic carcinoma (PCa) tissues, but not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7138cd594821bd0753e95f4b69d765b6
https://doi.org/10.1007/s00535-006-1857-3

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Expression of Mesothelin mRNA in Pure Pancreatic Juice From Patients With Pancreatic Carcinoma, Intraductal Papillary Mucinous Neoplasm of the Pancreas, and Chronic Pancreatitis

Autor: Norio Sawabu, Tokio Wakabayashi, Yasushi Yamaguchi, Gensaku Okada, Hiroyuki Watanabe, Yoshiharu Motoo, Hisatsugu Mouri, Koushiro Ohtsubo

Publikováno v: Pancreas. 30:349-354

In the gene expression analysis of pancreatic carcinoma (PCa) using serial analysis of gene expression (SAGE) according to Ryu et al, the tag for the mesothelin mRNA transcript was present in 7 of 8 SAGE libraries derived from PCa but not in the 2 SA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d949a986bb39b4467c739d89a469e4ba
https://doi.org/10.1097/01.mpa.0000160281.56828.76

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A case of pancreatic cancer with formation of a mass mimicking alcoholic or autoimmune pancreatitis in a young man. Possibility of diagnosis by hypermethylation of pure pancreatic juice

Autor: Koushiro, Ohtsubo, Hiroyuki, Watanabe, Gensaku, Okada, Tomoya, Tsuchiyama, Hisatsugu, Mouri, Yasushi, Yamaguchi, Yoshiharu, Motoo, Takashi, Okai, Koji, Amaya, Hirohisa, Kitagawa, Tetsuo, Ohta, Toshifumi, Gabata, Koichiro, Matsuda, Hideki, Ohta, Norio, Sawabu

Publikováno v: JOP : Journal of the pancreas. 9(1)

Mass-forming pancreatitis can be divided into two distinct types: alcoholic and autoimmune. There have been some cases of an ambiguous diagnosis although care was taken to differentiate between alcoholic mass-forming pancreatitis, focal type autoimmu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e78d585f39d99454cdd2aa402f0288e9
https://pubmed.ncbi.nlm.nih.gov/18182742

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Diagnostic utility of aberrant methylation of tissue factor pathway inhibitor 2 in pure pancreatic juice for pancreatic carcinoma

Autor: Tomoya Tsuchiyama, Gensaku Okada, Hiroyuki Watanabe, Norio Sawabu, Pei-Hong Jiang, Hisatsugu Mouri, Koushiro Ohtsubo, F. Yao

Publikováno v: Cancer science. 97(11)

医薬保健研究域医学系
The tissue factor pathway inhibitor 2 (TFPI-2) is a Kunitz-type serine proteinase inhibitor. Recently, the aberrant methylation of TFPI-2 was detected frequently in pancreatic carcinoma (PCa) tissues but not in nor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e6d98e949fd36daad7e3e1a3f199f31
https://pubmed.ncbi.nlm.nih.gov/16965396

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Aberrant methylation of secreted apoptosis-related protein 2 (SARP2) in pure pancreatic juice in diagnosis of pancreatic neoplasms

Autor: Koushiro Ohtsubo, Tokio Wakabayashi, Gensaku Okada, Hiroyuki Watanabe, Norio Sawabu, F. Yao, Hisatsugu Mouri, Pei-Hong Jiang

Publikováno v: Pancreas. 32(4)

Secreted apoptosis-related protein (SARP) families are considered to counteract the oncogenic Wnt signaling pathway, and inactivation of this gene may aid cancer development and progression. Recently, the aberrant methylation of SARP2 was detected fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa0a23a57ed8bc8c53ff01def5d34e2e
https://pubmed.ncbi.nlm.nih.gov/16670620

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Expression of vacuole membrane protein 1 (VMP1) in spontaneous chronic pancreatitis in the WBN/Kob rat

Autor: Juan L. Iovanna, Gensaku Okada, Mar a In s Vaccaro, Yoshiharu Motoo, Norio Sawabu, Pei-Hong Jiang

Publikováno v: Pancreas. 29(3)

OBJECTIVES: VMP1 is a stress-induced gene that is overexpressed in acute pancreatitis. Its overexpression promotes the formation of intracellular vacuoles and cell death. We investigated the expression of VMP1 mRNA and its relation to apoptosis in sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e3782320f5d027eed5e00759b7e58c0
https://pubmed.ncbi.nlm.nih.gov/15367889

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Tumor protein p53-induced nuclear protein 1 (TP53INP1) in spontaneous chronic pancreatitis in the WBN/Kob rat: drug effects on its expression in the pancreas

Autor: Pei-Hong, Jiang, Yoshiharu, Motoo, Juan Lucio, Iovanna, Marie-Josèphe, Pébusque, Min-Jue, Xie, Gensaku, Okada, Norio, Sawabu

Publikováno v: JOP : Journal of the pancreas. 5(4)

The tumor protein p53-induced nuclear protein 1 (TP53INP1) gene was found using DNA microarray technology as an overexpressed gene in acute pancreatitis. However, expression of TP53INP1 in chronic pancreatitis has not been previously reported.This st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0ea451328b42b10fcbf9b9e2764c5f1f
https://pubmed.ncbi.nlm.nih.gov/15254349

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