Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Genqing Liang"'
Autor:
Ruchi Sharma, Aman George, Malika Nimmagadda, Davide Ortolan, Barbosa-Sabanero Karla, Zoya Qureshy, Devika Bose, Roba Dejene, Genqing Liang, Qin Wan, Justin Chang, Balendu Shekhar Jha, Omar Memon, Kiyoharu Joshua Miyagishima, Aaron Rising, Madhu Lal, Eric Hanson, Rebecca King, Mercedes Maria Campos, Marc Ferrer, Juan Amaral, David McGaughey, Kapil Bharti
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Age-related macular degeneration is characterized by lipid-rich drusen deposits underneath the retinal pigment epithelium (RPE). Here the authors report an in vitro iPSC-RPE model for AMD that recapitulates drusen and RPE atrophy, and identify two dr
Externí odkaz:
https://doaj.org/article/988dc6dedea34110a9215b08c61d924e
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Kiyoharu J. Miyagishima, Aaron Rising, Haohua Qian, Yuan Wang, Malika Nimmagadda, Roba Dejene, Jennifer Martinez, Genqing Liang, Lijin Dong, Megan Kopera, Arvydas Maminishkis, Sheldon S. Miller, Ruchi Sharma, Mones Abu-Asab, Congxiao Zhang, Yichao Li
Publikováno v:
Hum Mol Genet
MicroRNA-204 (miR-204) is expressed in pulmonary, renal, mammary and eye tissue, and its reduction can result in multiple diseases including cancer. We first generated miR-204−/− mice to study the impact of miR-204 loss on retinal and retinal pig
Autor:
Genqing Liang, Elena Choleris, Kimberly Cai, Patricia V. Turner, Ray Lu, Amanda C. Martyn, Daniel Gillis, John N. Armstrong, Talya R. Amor, Adam R. R. McCluggage
Publikováno v:
Molecular and Cellular Biology. 32:5140-5150
The hypothalamic-pituitary-adrenal (HPA) axis is a major part of the neuroendocrine system in animal responses to stress. It is known that the HPA axis is attenuated at parturition to prevent detrimental effects of glucocorticoid secretion including
Autor:
Anne Bothmer, Arito Yamane, Rafael Casellas, Thiago Y. Oliveira, Michel C. Nussenzweig, Hirotaka Nakahashi, Mila Jankovic, Isaac A. Klein, Davide F. Robbiani, Camilo Ansarah-Sobrinho, Gordon L. Hager, Genqing Liang, Wolfgang Resch, Ewy Mathé, Ty C. Voss, Kyong-Rim Kieffer-Kwon, Ofir Hakim, Jesse Cobell, André Nussenzweig
Publikováno v:
Nature. 484:69-74
Recurrent chromosomal translocations underlie both haematopoietic and solid tumours. Their origin has been ascribed to selection of random rearrangements, targeted DNA damage, or frequent nuclear interactions between translocation partners; however,
Publikováno v:
Cell Stress and Chaperones. 17:473-483
Accumulation of mis- and unfolded proteins during viral replication can cause stress in the endoplasmic reticulum (ER) and trigger the unfolded protein response (UPR). If unchecked, this process may induce cellular changes detrimental to viral replic
Publikováno v:
Journal of Biological Chemistry. 284:21719-21727
Aberrant activity of the phosphatidylinositol 3-kinase (PI3K) pathway supports growth of many tumors including those of breast, lung, and prostate. Resistance of breast cancer cells to targeted chemotherapies including tyrosine kinase inhibitors (TKI
Publikováno v:
FEBS Journal. 275:4675-4683
TRPP2, also called polycystin-2, the gene product of PKD2, is a membrane protein defective in 10-15% of cases of autosomal dominant polycystic kidney disease. Mutations in PKD2 are also associated with extrarenal disorders, such as hepatic cystogenes
Publikováno v:
The FASEB Journal. 29
Publikováno v:
The FASEB Journal. 29