A widespread family of WYL-domain transcriptional regulators co-localizes with diverse phage defence systems and islands

Autor: David M. Picton, Joshua D. Harling-Lee, Samuel J. Duffner, Sam C. Went, Richard D. Morgan, Jay C. D. Hinton, Tim R. Blower

Publikováno v: Nucleic Acids Research, 2022, Vol.50(9), pp.5191-5207 [Peer Reviewed Journal]
Picton, D M, Harling-Lee, J D, Duffner, S J, Went, S C, Morgan, R D, Hinton, J C D & Blower, T R 2022, ' A widespread family of WYL-domain transcriptional regulators co-localizes with diverse phage defence systems and islands ', Nucleic Acids Research, vol. 50, no. 9, pp. 5191-5207 . https://doi.org/10.1093/nar/gkac334

Bacteria are under constant assault by bacteriophages and other mobile genetic elements. As a result, bacteria have evolved a multitude of systems that protect from attack. Genes encoding bacterial defence mechanisms can be clustered into “defence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66cdf0a6ad2cbbdeac11b865b702df44
https://doi.org/10.1093/nar/gkac334

Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli

Autor: Arne Van Hoeck, Jens Puschhof, Axel Rosendahl Huber, Ruben van Boxtel, Reinier van der Linden, Fernanda L. Paganelli, K. Christopher Garcia, Stefan van der Elst, Matthew Meyerson, Hans Clevers, Guillaume Dalmasso, Marios Giannakis, Richard Bonnet, Paul B. Stege, Phil Quirke, Tomohiro Mizutani, Henry M. Wood, Edwin Cuppen, Rob J. L. Willems, Maarten H. Geurts, Carino Gurjao, Cayetano Pleguezuelos-Manzano, Joep Beumer, Freek Manders, Yi Miao, Janetta Top, Jason Nomburg

Publikováno v: Nature
Nature, Nature Publishing Group, 2020, 580 (7802), pp.269-273. ⟨10.1038/s41586-020-2080-8⟩
Nature, 580(7802), 269-273. Nature Publishing Group

International audience; Various species of the intestinal microbiota have been associated with the development of colorectal cancer(1,2), but it has not been demonstrated that bacteria have a direct role in the occurrence of oncogenic mutations. Esch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ea03f3d630c47a9677c25c397bbf599
https://doi.org/10.1038/s41586-020-2080-8

Salmonella genomic island 1 (SGI1) reshapes the mating apparatus of IncC conjugative plasmids to promote self-propagation

Autor: Charley Anquetil, Romain Durand, Malika Humbert, Nicolas Carraro, Vincent Burrus, Catherine Barrette, Nicolas Rivard

Publikováno v: PLoS Genetics, Vol 13, Iss 3, p e1006705 (2017)
PLoS Genetics
PLoS Genetics, vol. 13, no. 3, pp. e1006705

IncC conjugative plasmids and Salmonella genomic island 1 (SGI1) and relatives are frequently associated with multidrug resistance of clinical isolates of pathogenic Enterobacteriaceae. SGI1 is specifically mobilized in trans by IncA and IncC plasmid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4d2f01e037e6ee626c9857f59290fa
http://europepmc.org/articles/PMC5389848?pdf=render

Describing ancient horizontal gene transfers at the nucleotide and gene levels by comparative pathogenicity island genometrics

Autor: François Collyn, Claude-Alain H. Roten, Lionel Guy, Michel Simonet, Michael Marceau

Publikováno v: Bioinformatics, vol. 22, no. 9, pp. 1072-1079

Motivation: Lateral gene transfer is a major mechanism contributing to bacterial genome dynamics and pathovar emergence via pathogenicity island (PAI) spreading. However, since few of these genomic exchanges are experimentally reproducible, it is dif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::937b36059be157694846987037e7febc
https://doi.org/10.1093/bioinformatics/bti793

Molecular characterization of a Streptococcus gallolyticus genomic island encoding a pilus involved in endocarditis

Autor: José M. Entenza, Michel Débarbouillé, Camille Danne, Romain Briandet, Shaynoor Dramsi, Philippe Glaser, Patrick Trieu-Cuot, Philippe Moreillon, Grégory Jouvion, Adeline Mallet, Farida Nato

Publikováno v: Journal of Infectious Diseases
Journal of Infectious Diseases, Oxford University Press (OUP), 2011, 204 (12), pp.1960-70. ⟨10.1093/infdis/jir666⟩
Journal of Infectious Diseases, 2011, 204 (12), pp.1960-70. ⟨10.1093/infdis/jir666⟩
Journal of Infectious Diseases, vol. 204, no. 12, pp. 1960-1970

International audience; BACKGROUND: Streptococcus gallolyticus is a causative agent of infective endocarditis associated with colon cancer. Genome sequence of strain UCN34 revealed the existence of 3 pilus loci (pil1, pil2, and pil3). Pili are long f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35ed66a8230385848d68cd75e5a4bf0
https://hal.archives-ouvertes.fr/hal-01000633/document