Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Genome-wide CRISPR screen"'
Autor:
Li, Hao a, b, 1, Li, Yuqing a, b, 1, Zhang, Tiejun a, b, Liu, Song a, b, Song, Cailiang a, b, Wang, Kailu a, b, Yan, Wenjun a, b, Wang, Zheng a, b, Yang, Qingcheng a, b, Yang, Xin a, b, Wang, Hongning a, b, ⁎
Publikováno v:
In Veterinary Microbiology January 2025 300
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 4 (2024)
ABSTRACTBrucella is a zoonotic intracellular bacterium that poses threats to human health and economic security. Intracellular infection is a hallmark of the agent Brucella and a primary cause of distress, through which the bacterium regulates the ho
Externí odkaz:
https://doaj.org/article/3b187cb72ded4e808a88a85b1242b51f
Publikováno v:
Frontiers in Genome Editing, Vol 6 (2024)
Externí odkaz:
https://doaj.org/article/15735047c9974e9b815313a74d0bb23e
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 12, Pp 100465- (2023)
Accurate intracellular cholesterol traffic plays crucial roles. Niemann Pick type C (NPC) proteins NPC1 and NPC2, are two lysosomal cholesterol transporters that mediate the cholesterol exit from lysosomes. However, other proteins involved in this pr
Externí odkaz:
https://doaj.org/article/6077709dd9d34e4da493820344f2a460
Autor:
Kaveri Srivastava, Bhaswati Pandit
Publikováno v:
Frontiers in Genome Editing, Vol 5 (2023)
Inactivation or targeted disruption of a gene provides clues to assess the function of the gene in many cellular processes. Knockdown or knocking out a gene has been widely used for this purpose. However, recently CRISPR mediated genome editing has t
Externí odkaz:
https://doaj.org/article/27e2e924c876497ca6784ede6f2fe739
Akademický článek
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Akademický článek
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Autor:
Mingrui Du, Jintao Gu, Chenlin Liu, Nannan Liu, Zhe Yu, Chengpei Zhou, Wei Heng, Zhengcong Cao, Feilong Wei, Kailong Zhu, Yingwen Wang, Wei Zhang, Xiaochang Xue, Yong Zhang, Jixian Qian
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-18 (2022)
Abstract Background Osteosarcoma (OS) is a malignant bone tumor mostly occurring in children and adolescents, while chemotherapy resistance often develops and the mechanisms involved remain challenging to be fully investigated. Methods Genome-wide CR
Externí odkaz:
https://doaj.org/article/98f3abf100dd4751b0a5e17a857081dd
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Cancer immunotherapy targets the interplay between immune and cancer cells. In particular, interactions between cytotoxic T lymphocytes (CTLs) and cancer cells, such as PD-1 (PDCD1) binding PD-L1 (CD274), are crucial for cancer cell clearance. Howeve
Externí odkaz:
https://doaj.org/article/925e6ba5742747f8851d747d578a5061
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Emerging zoonotic viral pathogens threaten global health, and there is an urgent need to discover host and viral determinants influencing infection. We performed a loss-of-function genome-wide CRISPR screen in a human lung cell line using HC
Externí odkaz:
https://doaj.org/article/29a9b0d8514d4fa99e9345bace2d5c9e