Zobrazeno 1 - 10
of 1 204
pro vyhledávání: '"Genome-scale metabolic model"'
pan-Draft: automated reconstruction of species-representative metabolic models from multiple genomes
Autor:
Nicola De Bernardini, Guido Zampieri, Stefano Campanaro, Johannes Zimmermann, Silvio Waschina, Laura Treu
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-25 (2024)
Abstract The accurate reconstruction of genome-scale metabolic models (GEMs) for unculturable species poses challenges due to the incomplete and fragmented genetic information typical of metagenome-assembled genomes (MAGs). While existing tools lever
Externí odkaz:
https://doaj.org/article/67809d26033d4aedab3f807a39e96978
Publikováno v:
Synthetic and Systems Biotechnology, Vol 9, Iss 4, Pp 861-870 (2024)
Saccharomyces cerevisiae, a widely utilized model organism, has seen continuous updates to its genome-scale metabolic model (GEM) to enhance the prediction performance for metabolic engineering and systems biology. This study presents an auxotrophy-b
Externí odkaz:
https://doaj.org/article/796f6ddd73124aaf9b9db8ee37ea9b28
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Selective drugs with a relatively narrow spectrum can reduce the side effects of treatments compared to broad-spectrum antibiotics by specifically targeting the pathogens responsible for infection. Furthermore, combating an infectious pathog
Externí odkaz:
https://doaj.org/article/86d6df7c8f854474afb916106d74bcb6
Autor:
Antoine Champie, Jean-Christophe Lachance, Anand Sastry, Dominick Matteau, Colton J. Lloyd, Frédéric Grenier, Cameron R. Lamoureux, Simon Jeanneau, Adam M. Feist, Pierre-Étienne Jacques, Bernhard O. Palsson, Sébastien Rodrigue
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT Microorganisms with simplified genomes represent interesting cell chassis for systems and synthetic biology. However, genome reduction can lead to undesired traits, such as decreased growth rate and metabolic imbalances. To investigate the i
Externí odkaz:
https://doaj.org/article/04a55e0de4eb4ac2a7d3e89e6f0be8fb
Publikováno v:
Biotechnology for Biofuels and Bioproducts, Vol 17, Iss 1, Pp 1-13 (2024)
Abstract Background Aspergillus tubingensis is a citric acid-producing fungus that can utilize sugars in hydrolysate of lignocellulosic biomass such as sugarcane bagasse and, unlike A. niger, does not produce mycotoxins. To date, no attempt has been
Externí odkaz:
https://doaj.org/article/a604f0b433b3487698f0678fb7d7f05a
Autor:
GaRyoung Lee, Sang Mi Lee, Sungyoung Lee, Chang Wook Jeong, Hyojin Song, Sang Yup Lee, Hongseok Yun, Youngil Koh, Hyun Uk Kim
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-26 (2024)
Abstract Background Oncometabolites, often generated as a result of a gene mutation, show pro-oncogenic function when abnormally accumulated in cancer cells. Identification of such mutation-associated metabolites will facilitate developing treatment
Externí odkaz:
https://doaj.org/article/0467cfd1336a40f8bd499538e746a008
Autor:
Dingming Guo, Yun Deng, Qianqian Yang, Min Li, Xiangfeng Wang, Xuchun Wan, Junqing He, Ying Xu, Wenxin Huang, Guohua Lin, Ya Xu, Yi Sun, Ruilin Zhang, Wei-Hua Chen, Zhi Liu
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
Probiotics hold great potential for treating metabolic diseases such as obesity. Given the complex and multifactorial nature of these diseases, research on probiotic combination with multiple targets has become popular. Here, we choose four obesity-r
Externí odkaz:
https://doaj.org/article/b7a52fd2b9134f7b9033ffea1ed8ba36
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
ABSTRACTUlcerative colitis (UC) is a challenging form of inflammatory bowel disease, and its etiology is intricately linked to disturbances in the gut microbiome. To identify the potential alleviators of UC, we employed an integrative analysis combin
Externí odkaz:
https://doaj.org/article/6bfc803270de4504bc3de3959f0201b3
Publikováno v:
mSystems, Vol 9, Iss 7 (2024)
ABSTRACT Strains across the Lactobacillaceae family form the basis for a trillion-dollar industry. Our understanding of the genomic basis for their key traits is fragmented, however, including the metabolism that is foundational to their industrial u
Externí odkaz:
https://doaj.org/article/80bab6fb28754a78bb456bcdf19a30db
Publikováno v:
mSystems, Vol 9, Iss 6 (2024)
ABSTRACT In silico tools such as genome-scale metabolic models have shown to be powerful for metabolic engineering of microorganisms. Saccharomyces pastorianus is a complex aneuploid hybrid between the mesophilic Saccharomyces cerevisiae and the cold
Externí odkaz:
https://doaj.org/article/a0f9547ec9b844debbf26bde97d568b3